CA1322719C - Activator for osteoblast - Google Patents

Activator for osteoblast

Info

Publication number
CA1322719C
CA1322719C CA000584964A CA584964A CA1322719C CA 1322719 C CA1322719 C CA 1322719C CA 000584964 A CA000584964 A CA 000584964A CA 584964 A CA584964 A CA 584964A CA 1322719 C CA1322719 C CA 1322719C
Authority
CA
Canada
Prior art keywords
osteoblast
compound
salt
activator
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000584964A
Other languages
English (en)
French (fr)
Inventor
Hajime Orimo
Hiroshi Satoh
Kohei Miyao
Norihiro Kakimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asai Germanium Research Institute
Original Assignee
Asai Germanium Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asai Germanium Research Institute filed Critical Asai Germanium Research Institute
Application granted granted Critical
Publication of CA1322719C publication Critical patent/CA1322719C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/30—Germanium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000584964A 1987-12-07 1988-12-05 Activator for osteoblast Expired - Lifetime CA1322719C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62308982A JPH01149723A (ja) 1987-12-07 1987-12-07 骨芽細胞活性化剤
JP62-308982 1987-12-07

Publications (1)

Publication Number Publication Date
CA1322719C true CA1322719C (en) 1993-10-05

Family

ID=17987535

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000584964A Expired - Lifetime CA1322719C (en) 1987-12-07 1988-12-05 Activator for osteoblast

Country Status (8)

Country Link
US (1) US5002968A (enExample)
JP (1) JPH01149723A (enExample)
CA (1) CA1322719C (enExample)
CH (1) CH675725A5 (enExample)
DE (1) DE3840744C2 (enExample)
FR (1) FR2624120B1 (enExample)
GB (1) GB2213059B (enExample)
IT (1) IT1227884B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU635045B2 (en) * 1989-07-20 1993-03-11 Asai Germanium Research Institute Co., Ltd Agent for preventing and treating opacity of lens
JPH05255130A (ja) * 1992-03-16 1993-10-05 Asai Gerumaniumu Kenkyusho:Kk メイラード反応抑制改善剤
AU2003230850A1 (en) * 2002-04-10 2003-10-27 Surromed, Inc. Propagermanium for treating myeloma bone disease and other bone disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA970277A (en) * 1972-05-25 1975-07-01 Kazuhiko Asai Organo germanium sesquioxide composition for treating hypertension or hypotonia
JPS55122717A (en) * 1979-03-15 1980-09-20 Asai Gerumaniumu Kenkyusho:Kk Interferon inducer
JPS60185715A (ja) * 1984-03-05 1985-09-21 Teijin Ltd 骨形成促進剤
JPS61145116A (ja) * 1984-12-18 1986-07-02 Asai Gerumaniumu Kenkyusho:Kk オステオポロ−ジス治療剤
JPS62252794A (ja) * 1986-04-09 1987-11-04 Asai Gerumaniumu Kenkyusho:Kk 有機ゲルマニウム化合物及びそれを含む薬剤
JPS63107920A (ja) * 1986-06-18 1988-05-12 Asai Gerumaniumu Kenkyusho:Kk 骨芽細胞活性化剤
JP2698870B2 (ja) * 1987-10-29 1998-01-19 株式会社浅井ゲルマニウム研究所 シクロスポリンの投与による腎毒性の軽減剤
CA1314210C (en) * 1987-10-29 1993-03-09 Norihiro Kakimoto Agent for improving reduced functions of organs caused by inhibited blood circulation
JPH01117801A (ja) * 1987-10-29 1989-05-10 Asai Gerumaniumu Kenkyusho:Kk 分離臓器洗浄保存液

Also Published As

Publication number Publication date
CH675725A5 (enExample) 1990-10-31
DE3840744C2 (de) 1994-09-08
DE3840744A1 (de) 1989-06-15
GB2213059B (en) 1991-07-31
GB2213059A (en) 1989-08-09
GB8828208D0 (en) 1989-01-05
IT8822885A0 (it) 1988-12-06
FR2624120A1 (fr) 1989-06-09
IT1227884B (it) 1991-05-14
FR2624120B1 (fr) 1994-02-25
US5002968A (en) 1991-03-26
JPH01149723A (ja) 1989-06-12

Similar Documents

Publication Publication Date Title
CA1261849A (en) L-lysine pyruvate and l-histidine pyruvate
US4299838A (en) Tryptophan derivatives having an increased effect on the central nervous system
KR900005518B1 (ko) 퓨로-(3,4-c)-피리딘 유도체의 제조방법
IE48336B1 (en) Ornithine and arginine salts of branched chain keto acids
CN107325201A (zh) 一种壳聚糖‑水杨酸‑稀土配合物的制备方法
JP2921124B2 (ja) 酸化型グルタチオンアルキルエステル
CA1188305A (en) Ester of metronidazole with n,n-dimethylglycine and acid addition salt thereof
JP2951344B2 (ja) 化学療法における毒性特性の改良
US5002968A (en) Activator for osteoblasts
US4973553A (en) Salt or organogermanium compound and medicine containing the same
US4822817A (en) Remedy for bone disease
IE902656A1 (en) Salts of n5,n10-methylene-5,6,7,8-tetrahydrofolic acid
EP0767777B1 (en) New salts of 2-[(2,6-dichlorophenyl)amine]phenylacetoxyacetic acid with organic basic cations
CN101781330B (zh) 丙泊酚磷酸酯氨基酸复盐及其制备方法和应用
US5661154A (en) Oxypurinol alkali and alkaline earth salts in amorphorous or crystalline form as agents for treating hyperuricaemia and gout
JP2954989B2 (ja) ビスフェノール誘導体での真性糖尿病処置法
US5475028A (en) 2-aminoethanesulfonic acid zinc complex
CN114349665A (zh) 二甲双胍焦谷氨酸晶体及其制备方法与应用
US3928590A (en) Ortho-mercaptoaroylamides and salts thereof as hypoglycemic agents
JPH04501253A (ja) 抗腫瘍剤として有用なホスホラミド
JPH072867A (ja) ビオチンアミド誘導体の製造方法及び、それらを含有する糖尿病及び糖尿病合併症の治療剤
JPS61145116A (ja) オステオポロ−ジス治療剤
US3242048A (en) Betaine glutamate and methods of using same
JPS62252794A (ja) 有機ゲルマニウム化合物及びそれを含む薬剤
JPH07247297A (ja) 炭素クラスター誘導体

Legal Events

Date Code Title Description
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121205