CA1298783C - Substitut acellulaire de globules rouges - Google Patents

Substitut acellulaire de globules rouges

Info

Publication number
CA1298783C
CA1298783C CA000540186A CA540186A CA1298783C CA 1298783 C CA1298783 C CA 1298783C CA 000540186 A CA000540186 A CA 000540186A CA 540186 A CA540186 A CA 540186A CA 1298783 C CA1298783 C CA 1298783C
Authority
CA
Canada
Prior art keywords
hemoglobin
solution
red blood
blood cell
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000540186A
Other languages
English (en)
Inventor
Lakshman R. Sehgal
Richard E. Dewoskin
Gerald S. Moss
Steven A. Gould
Arthur L. Rosen
Hansa L. Sehgal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northfield Laboratories Inc
Original Assignee
Northfield Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Laboratories Inc filed Critical Northfield Laboratories Inc
Application granted granted Critical
Publication of CA1298783C publication Critical patent/CA1298783C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA000540186A 1986-06-20 1987-06-19 Substitut acellulaire de globules rouges Expired - Lifetime CA1298783C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US876,689 1986-06-20
US06/876,689 US4826811A (en) 1986-06-20 1986-06-20 Acellular red blood cell substitute

Publications (1)

Publication Number Publication Date
CA1298783C true CA1298783C (fr) 1992-04-14

Family

ID=25368368

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000540186A Expired - Lifetime CA1298783C (fr) 1986-06-20 1987-06-19 Substitut acellulaire de globules rouges

Country Status (11)

Country Link
US (1) US4826811A (fr)
EP (1) EP0271542B1 (fr)
JP (1) JP2983544B2 (fr)
CA (1) CA1298783C (fr)
DE (2) DE3790322T1 (fr)
FR (1) FR2600255B1 (fr)
GB (2) GB8801735D0 (fr)
IL (1) IL82890A0 (fr)
NL (1) NL194909C (fr)
PT (1) PT85133B (fr)
WO (1) WO1987007832A1 (fr)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194590A (en) * 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
CA1312009C (fr) * 1986-11-10 1992-12-29 Carl W. Rausch Substitut sanguin semi-synthetique extra pur
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5164272A (en) * 1987-12-03 1992-11-17 Chloride Silent Power Limited Alkali metal cell
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
IL87707A (en) * 1988-09-08 1994-06-24 Technion Inst For Research And Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof
NL8901174A (nl) * 1989-05-10 1990-12-03 Het Hoofd Van De Afdeling Mili Hemoglobine-preparaat en gebruik daarvan.
US5545727A (en) 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
HUT64571A (en) * 1990-11-29 1994-01-28 Upjohn Co A method for producing hemoglobin preparatives containing imido ester cross bind
DE69226197T2 (de) * 1991-11-08 1999-02-11 Somatogen Inc Hämoglobine als arzneimittelabgabesystem
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5900477A (en) * 1992-01-30 1999-05-04 Baxter International, Inc. Use of hemoglobin in the treatment of hemorrhagic shock
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US6187744B1 (en) * 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
JPH09500642A (ja) * 1993-07-23 1997-01-21 ジ・アップジョン・カンパニー ヘモグロビンの投与方法
IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6458762B1 (en) 1994-03-28 2002-10-01 Baxter International, Inc. Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
DE4418973A1 (de) * 1994-05-31 1995-12-14 Barnikol Wolfgang Verfahren zur Herstellung molekular-einheitlicher hyperpolymerer Hämoglobine
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
EP0767675A4 (fr) * 1995-04-10 1998-08-05 Baxter Int Utilisation d'hemoglobine reticulee dans le traitement des hemorragies sous-arachnoidiennes
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5733869A (en) * 1995-10-06 1998-03-31 Baxter International, Inc. Therapeutic administration of hemoglobin in cardiac arrest
JP2000502058A (ja) * 1995-11-30 2000-02-22 ソマトジェン，インコーポレイテッド ヘモグロビン架橋の際の機能性制御のための方法
CA2239303A1 (fr) 1995-12-22 1997-07-03 Somatogen, Inc. Globines incluant des domaines de liaison
JP2000507947A (ja) * 1996-03-28 2000-06-27 ノースフイールド ラボラトリーズ インコーポレイテツド 無細胞性赤血球代用物を製造する方法及び装置
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
EP0885613A1 (fr) * 1997-06-21 1998-12-23 Roche Diagnostics GmbH Application d'hémoglobine modifiée au traitement d'anémies et préparations mixtes à base d'hémoglobine modifiée et d'érythropoiétine
DE19802321C2 (de) * 1998-01-23 2000-05-11 Fresenius Ag Verfahren und Vorrichtung zur Aufbereitung von intra- oder postoperativen Blutverlusten für die Autotransfusion
JP5099951B2 (ja) 1999-11-12 2012-12-19 バクスター・インターナショナル・インコーポレイテッド 副作用が減少されたヘモグロビン組成物
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
CA2444590C (fr) 2001-04-18 2009-12-01 Robert L. Mcginnis Solutions d'hemoglobine stabilisees
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
AU2003207503A1 (en) * 2002-01-11 2003-07-30 Sangart, Inc. Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
EP1894573A3 (fr) 2002-01-11 2013-06-12 Sangart, Inc. Procédés et compositions pour le transport d'oxygène comprenant une forte affinité pour l'oxygène
US20050119161A1 (en) * 2002-01-11 2005-06-02 Winslow Robert M. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
EP1553968A4 (fr) * 2002-10-03 2009-06-24 Northfield Lab Methode de traitement de patients perdant beaucoup de sang
AU2003298768A1 (en) * 2002-12-02 2004-06-23 Biovec Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US7481998B2 (en) * 2002-12-02 2009-01-27 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US7803365B2 (en) * 2002-12-02 2010-09-28 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US9388427B2 (en) 2002-12-02 2016-07-12 Biovec, Llc In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
US7501114B2 (en) * 2002-12-02 2009-03-10 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
EP1592437A4 (fr) * 2003-01-29 2007-12-26 Northfield Lab Solutions d'hemoglobine polymerisees comportant une quantite reduite de tetramere et procede de fabrication correspondant
US7135554B1 (en) * 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
CN101039684A (zh) * 2004-08-31 2007-09-19 桑格特公司 使用氧载体组合物增强血液动力稳定性的方法
EP1865993A2 (fr) * 2005-04-05 2007-12-19 Biopure Corporation Solutions oxygenees d'hemoglobine polymerisee et leurs utilisations pour la visualisation de tissus oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20070196810A1 (en) * 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US20080118572A1 (en) * 2006-10-10 2008-05-22 Harold Richard Hellstrom Methods and compositions for reducing the risk of adverse cardiovascular events associated with the administration of artificial blood
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
AU2014259617B2 (en) 2013-05-03 2019-04-11 Washington University Blood substitute composition and method of use
WO2020080978A2 (fr) * 2018-10-19 2020-04-23 Рахимджан Ахметджанович РОЗИЕВ Procédé de production de substitut sanguin destiné à être utilisé en médecine vétérinaire
CN114146165B (zh) * 2021-12-02 2022-08-12 润方（北京）生物医药研究院有限公司 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
JPS52154515A (en) * 1976-04-23 1977-12-22 Biotest Serum Institut Gmbh Hemoglobin preparation strengthening oxygen release property
DE2617822C3 (de) * 1976-04-23 1981-01-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines für die intravenöse Injektion geeigneten Hämoglobinpräparates mit erhöhter Sauerstoffabgabe gegenüber Erythrozyten
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
DE3412144A1 (de) * 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen

Also Published As

Publication number Publication date
GB8801735D0 (en) 1988-03-30
EP0271542B1 (fr) 1991-09-04
DE3790322C2 (de) 1999-09-02
DE3790322T1 (fr) 1988-09-15
NL194909C (nl) 2003-07-04
JP2983544B2 (ja) 1999-11-29
FR2600255B1 (fr) 1990-07-27
PT85133B (pt) 1990-03-30
FR2600255A1 (fr) 1987-12-24
IL82890A0 (en) 1987-12-20
GB2200639A (en) 1988-08-10
EP0271542A1 (fr) 1988-06-22
NL8720283A (nl) 1988-05-02
PT85133A (en) 1987-07-01
US4826811A (en) 1989-05-02
GB2200639B (en) 1990-12-12
WO1987007832A1 (fr) 1987-12-30
NL194909B (nl) 2003-03-03
JPH01501471A (ja) 1989-05-25

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