CA1278792C - Antipsychotic fused-ring pyridinylpiperazine derivatives - Google Patents

Antipsychotic fused-ring pyridinylpiperazine derivatives

Info

Publication number
CA1278792C
CA1278792C CA000503794A CA503794A CA1278792C CA 1278792 C CA1278792 C CA 1278792C CA 000503794 A CA000503794 A CA 000503794A CA 503794 A CA503794 A CA 503794A CA 1278792 C CA1278792 C CA 1278792C
Authority
CA
Canada
Prior art keywords
compound
formula
piperazinyl
butyl
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000503794A
Other languages
English (en)
French (fr)
Inventor
Joseph P. Yevich
James Stewart New
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Application granted granted Critical
Publication of CA1278792C publication Critical patent/CA1278792C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000503794A 1985-05-06 1986-03-11 Antipsychotic fused-ring pyridinylpiperazine derivatives Expired - Fee Related CA1278792C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73120185A 1985-05-06 1985-05-06
US731,201 1985-05-06

Publications (1)

Publication Number Publication Date
CA1278792C true CA1278792C (en) 1991-01-08

Family

ID=24938510

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000503794A Expired - Fee Related CA1278792C (en) 1985-05-06 1986-03-11 Antipsychotic fused-ring pyridinylpiperazine derivatives

Country Status (25)

Country Link
JP (1) JPH0753728B2 (sv)
KR (1) KR940000829B1 (sv)
CN (1) CN1017901B (sv)
AT (1) AT398572B (sv)
AU (1) AU593244B2 (sv)
BE (1) BE904724A (sv)
CA (1) CA1278792C (sv)
CH (1) CH672787A5 (sv)
DE (1) DE3615180C2 (sv)
DK (1) DK165745C (sv)
EG (1) EG18206A (sv)
ES (6) ES8801250A1 (sv)
FI (1) FI85484C (sv)
FR (1) FR2581385B1 (sv)
GB (1) GB2174703B (sv)
GR (1) GR861149B (sv)
HU (1) HU195509B (sv)
IE (1) IE59201B1 (sv)
IT (1) IT1208607B (sv)
LU (1) LU86421A1 (sv)
MY (1) MY100777A (sv)
NL (1) NL8601146A (sv)
PT (1) PT82523B (sv)
SE (1) SE465270B (sv)
ZA (1) ZA862046B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
IE903410A1 (en) * 1989-10-09 1991-04-10 Novo Nordisk As Indole derivatives, their preparation and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
FR2738824B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1 -yl)alkyl)-3,4-dihydroquinazolin-2(1h)-one,leur preparation et leur application en therapeutique
JP3335362B2 (ja) * 1995-09-15 2002-10-15 サノフィ―サンテラボ キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト
FR2738822B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines

Also Published As

Publication number Publication date
JPH0753728B2 (ja) 1995-06-07
GB2174703B (en) 1988-10-26
HU195509B (en) 1988-05-30
ES557757A0 (es) 1988-04-01
EG18206A (en) 1992-09-30
AU5679586A (en) 1986-11-13
ES557855A0 (es) 1989-05-16
DK165745C (da) 1993-06-14
ATA121486A (de) 1994-05-15
CH672787A5 (sv) 1989-12-29
DE3615180C2 (de) 1996-03-07
IE861193L (en) 1986-11-06
DE3615180A1 (de) 1986-11-06
SE465270B (sv) 1991-08-19
KR940000829B1 (ko) 1994-02-02
DK207186A (da) 1986-11-07
ES8801250A1 (es) 1987-12-16
DK165745B (da) 1993-01-11
IT8620313A0 (it) 1986-05-06
FI861820A (fi) 1986-11-07
ES557839A0 (es) 1989-01-16
MY100777A (en) 1991-02-14
AU593244B2 (en) 1990-02-08
ZA862046B (en) 1986-11-26
IT1208607B (it) 1989-07-10
SE8602061D0 (sv) 1986-05-05
CN86103071A (zh) 1987-03-18
IE59201B1 (en) 1994-01-26
ES554659A0 (es) 1987-12-16
DK207186D0 (da) 1986-05-05
NL8601146A (nl) 1986-12-01
LU86421A1 (fr) 1986-12-05
HUT43848A (en) 1987-12-28
ES9000005A1 (es) 1989-11-01
FI85484B (fi) 1992-01-15
JPS61268681A (ja) 1986-11-28
ES8900138A1 (es) 1989-01-16
BE904724A (fr) 1986-11-05
PT82523A (en) 1986-06-01
ES8802149A1 (es) 1988-04-01
FR2581385A1 (fr) 1986-11-07
GR861149B (en) 1986-09-09
KR860009008A (ko) 1986-12-19
CN1017901B (zh) 1992-08-19
FI861820A0 (fi) 1986-04-30
FR2581385B1 (fr) 1991-10-04
SE8602061L (sv) 1986-11-07
AT398572B (de) 1994-12-27
FI85484C (sv) 1992-04-27
ES8802614A1 (es) 1988-09-01
ES8900253A1 (es) 1989-05-16
PT82523B (pt) 1988-10-14
GB2174703A (en) 1986-11-12
ES557809A0 (es) 1988-09-01
GB8610810D0 (en) 1986-06-11

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