CA1264668C - EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES - Google Patents

EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Info

Publication number
CA1264668C
CA1264668C CA483485A CA483485A CA1264668C CA 1264668 C CA1264668 C CA 1264668C CA 483485 A CA483485 A CA 483485A CA 483485 A CA483485 A CA 483485A CA 1264668 C CA1264668 C CA 1264668C
Authority
CA
Canada
Prior art keywords
liposomes
extrusion techniques
producing
disclosure
size distribution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA483485A
Other languages
English (en)
French (fr)
Other versions
CA1264668A (en
Inventor
Pieter R Cullis
Michael J Hope
Marcel B Bally
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA483485A priority Critical patent/CA1264668C/en
Application granted granted Critical
Publication of CA1264668A publication Critical patent/CA1264668A/en
Publication of CA1264668C publication Critical patent/CA1264668C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA483485A 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES Expired CA1264668C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA483485A CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62269084A 1984-06-20 1984-06-20
US62250284A 1984-06-20 1984-06-20
US622,502 1984-06-20
US622,690 1984-06-20
CA483485A CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Publications (2)

Publication Number Publication Date
CA1264668A CA1264668A (en) 1990-01-23
CA1264668C true CA1264668C (en) 1990-01-23

Family

ID=27089214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA483485A Expired CA1264668C (en) 1984-06-20 1985-06-07 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES

Country Status (11)

Country Link
EP (1) EP0185756B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2537186B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1264668C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3579426D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK173397B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8608922A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR851485B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE58630B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT80678B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG21092G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1986000238A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (72)

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US5897873A (en) * 1984-04-12 1999-04-27 The Liposome Company, Inc. Affinity associated vaccine
US5231112A (en) * 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
MX9203291A (es) * 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US6759057B1 (en) 1986-06-12 2004-07-06 The Liposome Company, Inc. Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
WO1988007850A1 (en) * 1987-04-16 1988-10-20 The Liposome Company, Inc. Liposome continuous size reduction method and apparatus
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
US5262168A (en) * 1987-05-22 1993-11-16 The Liposome Company, Inc. Prostaglandin-lipid formulations
WO1988009170A1 (en) * 1987-05-22 1988-12-01 The Liposome Company, Inc. Prostaglandin-lipid formulations
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
US5948441A (en) * 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
DE3812816A1 (de) * 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
WO1990004943A1 (en) * 1988-11-09 1990-05-17 Unger Evan C Liposomal radiologic contrast agents
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
DK0478715T3 (da) * 1989-06-23 1996-08-05 Liposome Co Inc Målrettede liposomer og fremgangsmåder til liposom-protein-kobling
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
ATE138803T1 (de) * 1990-07-31 1996-06-15 Liposome Co Inc Anhäufung von aminosäuren und peptiden in liposomen
DE69118708T2 (de) * 1990-10-05 1996-10-31 The Liposome Co.,Inc., Princeton, N.J. Extrudierverfahren für liposomen
US6623671B2 (en) 1990-10-05 2003-09-23 Royden M. Coe Liposome extrusion process
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
EP1104678A2 (en) 1992-05-04 2001-06-06 UNGER, Evan C Method for hyperthermic potentiation of tissue
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
KR960702297A (ko) * 1993-05-21 1996-04-27 카롤 질레스피 리포좀 유도된 불리한 생리학적 반응감소 (reduction of liposome-induced adverse physiological reactions)
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US6235308B1 (en) 1994-06-10 2001-05-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treating hypertension
US5622715A (en) * 1994-06-10 1997-04-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of improving renal function
DE19515163C2 (de) * 1995-01-31 2002-11-28 Erich Politsch Vorrichtung zur Extrusion von Suspensionen
US5902604A (en) 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
NL1001380C2 (nl) * 1995-10-09 1997-04-11 Fuji Photo Film Bv Methode voor het dispergeren van een geëmulgeerd materiaal van het olie-druppeltype in een vloeistoftoevoersysteem en bekledingsmethode waarbij van een dergelijke dispergeermethode gebruik wordt gemaakt.
ATE243998T1 (de) 1995-10-12 2003-07-15 Supergen Inc Liposomformulierung von 5-beta steroiden
DE19542499A1 (de) 1995-11-15 1997-05-22 Bayer Ag Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
IT1289939B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ATE409495T1 (de) 2001-04-04 2008-10-15 Nordic Vaccine Technology As Polynukleotide-bindende komplexe die sterolen und saponine enthalten
WO2004043580A1 (en) 2002-11-14 2004-05-27 K.U.Leuven Research & Development Method for preparing emulsions
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
US9271932B2 (en) 2006-04-28 2016-03-01 Children's Hospital Medical Center Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems
KR20080012605A (ko) 2006-08-04 2008-02-12 삼성에스디아이 주식회사 탄성 에너지 장벽을 이용한 생체막 소자
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
EP2646107A2 (en) 2010-12-01 2013-10-09 Spinal Modulation Inc. Agent delivery systems for selective neuromodulation
US20150216998A1 (en) 2012-01-01 2015-08-06 Ramot At Tel-Aviv University Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
RU2649805C2 (ru) * 2013-03-14 2018-04-04 Биорест Лтд. Липосомный состав и его получение
WO2018005657A1 (en) * 2016-06-28 2018-01-04 Verily Life Sciences Llc Serial filtration to generate small cholesterol-containing liposomes
JP6403026B2 (ja) * 2017-06-29 2018-10-10 バイオレスト リミテッド リポソーム、リポソームを含む処方剤、および処方剤の製造方法
WO2024175457A1 (en) * 2023-02-23 2024-08-29 Evonik Operations Gmbh Small scale liposome extruder

Family Cites Families (4)

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JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4263428A (en) * 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation

Also Published As

Publication number Publication date
DK77986A (da) 1986-02-19
CA1264668A (en) 1990-01-23
IE58630B1 (en) 1993-10-20
SG21092G (en) 1992-04-16
EP0185756A1 (en) 1986-07-02
EP0185756B1 (en) 1990-08-29
PT80678B (pt) 1987-08-19
ES8608922A1 (es) 1986-09-01
JP2537186B2 (ja) 1996-09-25
IE851514L (en) 1985-12-20
GR851485B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-11-25
DE3579426D1 (de) 1990-10-04
WO1986000238A1 (en) 1986-01-16
EP0185756A4 (en) 1987-09-02
DK173397B1 (da) 2000-09-18
DK77986D0 (da) 1986-02-19
JPS61502452A (ja) 1986-10-30
PT80678A (en) 1985-07-01
ES544364A0 (es) 1986-09-01

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20070123