CA1226777A - Transdermal drug applicator - Google Patents
Transdermal drug applicatorInfo
- Publication number
- CA1226777A CA1226777A CA000474498A CA474498A CA1226777A CA 1226777 A CA1226777 A CA 1226777A CA 000474498 A CA000474498 A CA 000474498A CA 474498 A CA474498 A CA 474498A CA 1226777 A CA1226777 A CA 1226777A
- Authority
- CA
- Canada
- Prior art keywords
- applicator
- medicament
- skin
- reservoir
- transdermal drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title claims abstract description 161
- 229940079593 drug Drugs 0.000 title claims abstract description 93
- 239000000463 material Substances 0.000 claims abstract description 29
- 239000000853 adhesive Substances 0.000 claims abstract description 13
- 230000001070 adhesive effect Effects 0.000 claims abstract description 13
- 210000004369 blood Anatomy 0.000 claims abstract description 13
- 239000008280 blood Substances 0.000 claims abstract description 13
- 238000013508 migration Methods 0.000 claims abstract description 12
- 230000005012 migration Effects 0.000 claims abstract description 12
- 239000004020 conductor Substances 0.000 claims abstract description 8
- 239000011248 coating agent Substances 0.000 claims abstract description 7
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- 239000010410 layer Substances 0.000 claims description 38
- 230000008859 change Effects 0.000 claims description 16
- 238000005370 electroosmosis Methods 0.000 claims description 16
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- 150000002500 ions Chemical class 0.000 claims description 12
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- 238000001962 electrophoresis Methods 0.000 claims description 9
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- 230000001105 regulatory effect Effects 0.000 claims description 7
- 239000000523 sample Substances 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
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- 238000009877 rendering Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 description 12
- 238000010276 construction Methods 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 9
- 241000283973 Oryctolagus cuniculus Species 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 6
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 6
- 229960000268 spectinomycin Drugs 0.000 description 6
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- 229920001940 conductive polymer Polymers 0.000 description 3
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- 239000002245 particle Substances 0.000 description 3
- 229960003604 testosterone Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
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- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000009533 lab test Methods 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 240000002989 Euphorbia neriifolia Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241001233242 Lontra Species 0.000 description 1
- 235000002779 Morchella esculenta Nutrition 0.000 description 1
- 240000002769 Morchella esculenta Species 0.000 description 1
- RAQQRQCODVNJCK-JLHYYAGUSA-N N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(2-hydroxyethyldisulfanyl)pent-2-en-2-yl]formamide Chemical compound C\C(N(Cc1cnc(C)nc1N)C=O)=C(\CCO)SSCCO RAQQRQCODVNJCK-JLHYYAGUSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 241001504505 Troglodytes troglodytes Species 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 238000012856 packing Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
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- 238000005086 pumping Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Electrotherapy Devices (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/660,192 US4622031A (en) | 1983-08-18 | 1984-10-12 | Indicator for electrophoretic transcutaneous drug delivery device |
| US8500080 | 1985-01-17 | ||
| US660,192 | 1991-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1226777A true CA1226777A (en) | 1987-09-15 |
Family
ID=24648527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000474498A Expired CA1226777A (en) | 1984-10-12 | 1985-02-15 | Transdermal drug applicator |
Country Status (13)
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4856188A (en) * | 1984-10-12 | 1989-08-15 | Drug Delivery Systems Inc. | Method for making disposable and/or replenishable transdermal drug applicators |
| US4731926A (en) * | 1985-02-19 | 1988-03-22 | Drug Delivery Systems Inc. | Method of manufacturing disposable and/or replenishable transdermal drug applicators |
| US5591123A (en) * | 1983-08-18 | 1997-01-07 | Drug Delivery Systems Inc. | Programmable control mounting system for transdermal drug applicator |
| US5135477A (en) * | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
| AU597890B2 (en) * | 1986-03-14 | 1990-06-14 | Drug Delivery Systems Inc. | Transdermal drug applicator and electrodes therefor |
| IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
| US4734090A (en) * | 1986-07-18 | 1988-03-29 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator |
| US4725263A (en) * | 1986-07-31 | 1988-02-16 | Medtronic, Inc. | Programmable constant current source transdermal drug delivery system |
| DE3703321A1 (de) * | 1986-09-01 | 1988-03-10 | Transcutan Gmbh | Therapievorrichtung zur anwendung von elektrischem strom |
| US4822334A (en) * | 1986-12-04 | 1989-04-18 | Robert Tapper | Electrical dosimetry control system |
| US4878892A (en) * | 1987-02-10 | 1989-11-07 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of polypeptides |
| AU609769B2 (en) * | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| CA1317522C (en) * | 1987-03-20 | 1993-05-11 | Dan Sibalis | Transdermal drug delivery system |
| DE3714140A1 (de) * | 1987-04-28 | 1988-11-10 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut |
| US5538736A (en) * | 1987-04-28 | 1996-07-23 | Lts Lohmann Therapie-Systeme Gmbh | Active substance-containing plaster for the controlled administration of active substances to the skin |
| US4865582A (en) * | 1987-06-05 | 1989-09-12 | Drug Delivery Systems Inc. | Disposable transdermal drug applicators |
| KR970008118B1 (ko) * | 1987-07-09 | 1997-05-21 | 엘테에스 로오만 테라피-지스테메 게엠베하 운트 콤파니 카게 | 피부 침투성 치료 시스템 |
| AU614092B2 (en) * | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
| ATE131081T1 (de) * | 1988-01-21 | 1995-12-15 | Massachusetts Inst Technology | Molekültransport durch gewebe mit der verwendung von elektroporation. |
| US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| WO1989006989A1 (en) * | 1988-01-29 | 1989-08-10 | The Regents Of The University Of California | Iontophoretic non-invasive sampling or delivery device |
| IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
| US5162042A (en) * | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
| WO1990000418A1 (en) * | 1988-07-15 | 1990-01-25 | P.R.D. Corporation | Fluid containing covers - with electrical circuits |
| US5169382A (en) * | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5496266A (en) * | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
| US5147296A (en) * | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
| JPH02218375A (ja) * | 1988-10-26 | 1990-08-31 | Advance Co Ltd | 電気的経皮投薬用インタフェース |
| US5006108A (en) * | 1988-11-16 | 1991-04-09 | Noven Pharmaceuticals, Inc. | Apparatus for iontophoretic drug delivery |
| US5241925A (en) * | 1988-12-27 | 1993-09-07 | Dermamed | Apparatus and techniques for administering veterinary medicaments |
| US5332577A (en) * | 1988-12-27 | 1994-07-26 | Dermamed | Transdermal administration to humans and animals |
| US5139023A (en) * | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
| US4950229A (en) * | 1989-09-25 | 1990-08-21 | Becton, Dickinson And Company | Apparatus for an electrode used for iontophoresis |
| FR2653023B1 (fr) * | 1989-10-12 | 1991-12-20 | Deficis Expl Brevets Alain | Systeme d'electrode perfectionnee destine a une utilisation en electrotherapie ou ionophorese. |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5032110A (en) * | 1989-12-05 | 1991-07-16 | Wataru Watanabe | Electrotherapeutical device |
| US5324521A (en) * | 1989-12-18 | 1994-06-28 | Dermamed | Systems for transdermal administration of medicaments |
| JPH05506165A (ja) * | 1990-03-30 | 1993-09-16 | アルザ・コーポレーション | イオン導入用送出装置 |
| DK0521988T3 (da) * | 1990-03-30 | 1996-04-29 | Alza Corp | Anordning til iontoforetisk lægemiddeltilførsel |
| US6004309A (en) | 1990-03-30 | 1999-12-21 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
| US5207752A (en) * | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| US5125894A (en) * | 1990-03-30 | 1992-06-30 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
| US5087241A (en) * | 1990-07-24 | 1992-02-11 | Empi, Inc. | Iontophoresis electrode with reservoir and injection site |
| US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US5246417A (en) * | 1991-12-11 | 1993-09-21 | Alza Corporation | Indicator for iontophoresis system |
| EP0751801B1 (en) * | 1992-06-02 | 1997-11-26 | Alza Corporation | Electrotransport drug delivery device |
| US5312326A (en) * | 1992-06-02 | 1994-05-17 | Alza Corporation | Iontophoretic drug delivery apparatus |
| USD357742S (en) | 1992-12-31 | 1995-04-25 | Alza Corporation | Electrotransport drug delivery system |
| EP0776677B1 (en) * | 1992-12-31 | 2000-03-08 | Alza Corporation | Electrotransport system |
| USD357743S (en) | 1992-12-31 | 1995-04-25 | Alza Corporation | Electrotransport drug delivery system |
| EP0616818A3 (en) * | 1993-03-26 | 1995-04-05 | Tech Res Ass Med & Welfare App | Iontophoresis device. |
| US5445609A (en) * | 1993-05-28 | 1995-08-29 | Alza Corporation | Electrotransport agent delivery device having a disposable component and a removable liner |
| US5458569A (en) * | 1993-06-08 | 1995-10-17 | Becton Dickinson And Company | Wearable iontophoresis system |
| EP0636386A1 (en) * | 1993-07-30 | 1995-02-01 | Cino Rossi | Disposable device for extracorporeal electrochemical therapy |
| FR2709670B1 (fr) * | 1993-09-10 | 1995-10-20 | Asulab Sa | Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse. |
| US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
| US5795321A (en) * | 1994-09-30 | 1998-08-18 | Becton Dickinson And Company | Iontophoretic drug delivery system, including removable controller |
| WO1996010441A1 (en) * | 1994-09-30 | 1996-04-11 | Becton Dickinson And Company | Iontophoretic drug delivery system, including disposable patch and reusable, removable controller |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| WO1997011742A1 (en) * | 1995-09-28 | 1997-04-03 | Becton Dickinson And Company | Iontophoretic drug delivery system, including disposable patch |
| ZA9610374B (en) * | 1995-12-11 | 1997-06-23 | Elan Med Tech | Cartridge-based drug delivery device |
| US6175763B1 (en) | 1996-03-29 | 2001-01-16 | Alza Corporation | Electrotransport drug delivery device having tactile signaling means |
| WO1997048444A1 (en) * | 1996-06-19 | 1997-12-24 | Becton Dickinson And Company | Iontophoretic delivery of cell adhesion inhibitors |
| AU725913B2 (en) * | 1996-11-21 | 2000-10-26 | Laboratoires D'hygiene Et De Dietetique (L.H.D.) | Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine |
| FR2756032B1 (fr) * | 1996-11-21 | 1999-02-05 | Lhd Lab Hygiene Dietetique | Vanne miniature et son procede de fabrication, dispositif de remplissage de reservoir comprenant une telle vanne |
| DE29700578U1 (de) * | 1997-01-15 | 1997-03-20 | Rheinmagnet Horst Baermann GmbH, 53819 Neunkirchen-Seelscheid | Pflaster zur transdermalen Applikation von Wirkstoffen |
| US6119036A (en) * | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
| AU8444698A (en) | 1997-06-30 | 1999-01-25 | Centre National De La Recherche Scientifique | Improved method for transferring nucleic acid into multicelled eukaryo tic organism cells and combination therefor |
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-
1984
- 1984-10-12 US US06/660,192 patent/US4622031A/en not_active Expired - Lifetime
-
1985
- 1985-01-17 EP EP85901143A patent/EP0197937A1/en not_active Withdrawn
- 1985-01-17 AU AU39352/85A patent/AU580585B2/en not_active Ceased
- 1985-01-17 WO PCT/US1985/000080 patent/WO1986002277A1/en unknown
- 1985-01-17 MX MX204285A patent/MX161423A/es unknown
- 1985-02-12 AR AR85299486A patent/AR241261A1/es active
- 1985-02-14 IT IT47685/85A patent/IT1186798B/it active
- 1985-02-15 CA CA000474498A patent/CA1226777A/en not_active Expired
- 1985-10-02 JP JP60219971A patent/JPS61100264A/ja active Pending
- 1985-10-07 BR BR8504939A patent/BR8504939A/pt not_active IP Right Cessation
- 1985-10-08 KR KR1019850007418A patent/KR940000071B1/ko not_active Expired - Fee Related
- 1985-10-11 AT AT92114095T patent/ATE168570T1/de not_active IP Right Cessation
- 1985-10-11 EP EP92114095A patent/EP0513879B1/en not_active Expired - Lifetime
- 1985-10-11 AT AT85112911T patent/ATE92775T1/de not_active IP Right Cessation
- 1985-10-11 DE DE3588190T patent/DE3588190T2/de not_active Expired - Fee Related
- 1985-10-11 DE DE85112911T patent/DE3587518T2/de not_active Expired - Fee Related
- 1985-10-11 EP EP85112911A patent/EP0178601B1/en not_active Expired - Lifetime
-
1986
- 1986-10-24 US US06/922,518 patent/US4713050A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3587518D1 (de) | 1993-09-16 |
| US4622031A (en) | 1986-11-11 |
| EP0513879A2 (en) | 1992-11-19 |
| DE3588190D1 (de) | 1998-08-27 |
| EP0513879A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-02-22 |
| EP0178601A3 (en) | 1987-08-19 |
| DE3587518T2 (de) | 1993-12-02 |
| US4713050A (en) | 1987-12-15 |
| MX161423A (es) | 1990-09-24 |
| EP0178601A2 (en) | 1986-04-23 |
| ATE92775T1 (de) | 1993-08-15 |
| WO1986002277A1 (en) | 1986-04-24 |
| ATE168570T1 (de) | 1998-08-15 |
| AR241261A1 (es) | 1992-04-30 |
| KR940000071B1 (ko) | 1994-01-05 |
| IT1186798B (it) | 1987-12-16 |
| EP0513879B1 (en) | 1998-07-22 |
| AU580585B2 (en) | 1989-01-19 |
| IT8547685A0 (it) | 1985-02-14 |
| DE3588190T2 (de) | 1999-02-04 |
| KR860003029A (ko) | 1986-05-19 |
| EP0178601B1 (en) | 1993-08-11 |
| EP0197937A1 (en) | 1986-10-22 |
| AU3935285A (en) | 1986-05-02 |
| JPS61100264A (ja) | 1986-05-19 |
| BR8504939A (pt) | 1986-07-22 |
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