IT1186798B - Applicatore di farmaci trans-cutaneo - Google Patents

Applicatore di farmaci trans-cutaneo

Info

Publication number
IT1186798B
IT1186798B IT47685/85A IT4768585A IT1186798B IT 1186798 B IT1186798 B IT 1186798B IT 47685/85 A IT47685/85 A IT 47685/85A IT 4768585 A IT4768585 A IT 4768585A IT 1186798 B IT1186798 B IT 1186798B
Authority
IT
Italy
Prior art keywords
trans
drug applicator
cutaneous drug
cutaneous
applicator
Prior art date
Application number
IT47685/85A
Other languages
English (en)
Other versions
IT8547685A0 (it
Inventor
Dan Sibalis
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Publication of IT8547685A0 publication Critical patent/IT8547685A0/it
Application granted granted Critical
Publication of IT1186798B publication Critical patent/IT1186798B/it

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
IT47685/85A 1984-10-12 1985-02-14 Applicatore di farmaci trans-cutaneo IT1186798B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/660,192 US4622031A (en) 1983-08-18 1984-10-12 Indicator for electrophoretic transcutaneous drug delivery device
PCT/US1985/000080 WO1986002277A1 (en) 1984-10-12 1985-01-17 Transdermal drug applicator

Publications (2)

Publication Number Publication Date
IT8547685A0 IT8547685A0 (it) 1985-02-14
IT1186798B true IT1186798B (it) 1987-12-16

Family

ID=24648527

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47685/85A IT1186798B (it) 1984-10-12 1985-02-14 Applicatore di farmaci trans-cutaneo

Country Status (13)

Country Link
US (2) US4622031A (it)
EP (3) EP0197937A1 (it)
JP (1) JPS61100264A (it)
KR (1) KR940000071B1 (it)
AR (1) AR241261A1 (it)
AT (2) ATE92775T1 (it)
AU (1) AU580585B2 (it)
BR (1) BR8504939A (it)
CA (1) CA1226777A (it)
DE (2) DE3588190T2 (it)
IT (1) IT1186798B (it)
MX (1) MX161423A (it)
WO (1) WO1986002277A1 (it)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
US5591123A (en) * 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US5135477A (en) * 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4734090A (en) * 1986-07-18 1988-03-29 Drug Delivery Systems Inc. Electrical transdermal drug applicator
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
DE3703321A1 (de) * 1986-09-01 1988-03-10 Transcutan Gmbh Therapievorrichtung zur anwendung von elektrischem strom
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
CA1317522C (en) * 1987-03-20 1993-05-11 Dan Sibalis Transdermal drug delivery system
US5538736A (en) * 1987-04-28 1996-07-23 Lts Lohmann Therapie-Systeme Gmbh Active substance-containing plaster for the controlled administration of active substances to the skin
DE3714140A1 (de) * 1987-04-28 1988-11-10 Lohmann Therapie Syst Lts Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
DE3722775A1 (de) * 1987-07-09 1989-01-19 Lohmann Therapie Syst Lts Transdermales therapeutisches system
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
ATE131081T1 (de) * 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
KR970011449B1 (ko) * 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
WO1990000418A1 (en) * 1988-07-15 1990-01-25 P.R.D. Corporation Fluid containing covers - with electrical circuits
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
JPH02218375A (ja) * 1988-10-26 1990-08-31 Advance Co Ltd 電気的経皮投薬用インタフェース
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US4950229A (en) * 1989-09-25 1990-08-21 Becton, Dickinson And Company Apparatus for an electrode used for iontophoresis
FR2653023B1 (fr) * 1989-10-12 1991-12-20 Deficis Expl Brevets Alain Systeme d'electrode perfectionnee destine a une utilisation en electrotherapie ou ionophorese.
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5032110A (en) * 1989-12-05 1991-07-16 Wataru Watanabe Electrotherapeutical device
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
US6004309A (en) * 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
DK0521988T3 (da) * 1990-03-30 1996-04-29 Alza Corp Anordning til iontoforetisk lægemiddeltilførsel
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
ES2208633T3 (es) * 1990-03-30 2004-06-16 Alza Corporation Dispositvoo de administracion iontoforetica.
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5087241A (en) * 1990-07-24 1992-02-11 Empi, Inc. Iontophoresis electrode with reservoir and injection site
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5246417A (en) * 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5312326A (en) * 1992-06-02 1994-05-17 Alza Corporation Iontophoretic drug delivery apparatus
ATE160510T1 (de) * 1992-06-02 1997-12-15 Alza Corp Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
ES2111907T3 (es) * 1992-12-31 1998-03-16 Alza Corp Sistema de electrotransporte que tiene medios flexibles.
EP0616818A3 (en) * 1993-03-26 1995-04-05 Tech Res Ass Med & Welfare App Iontophoresis device.
US5445609A (en) * 1993-05-28 1995-08-29 Alza Corporation Electrotransport agent delivery device having a disposable component and a removable liner
US5458569A (en) * 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
EP0636386A1 (en) * 1993-07-30 1995-02-01 Cino Rossi Disposable device for extracorporeal electrochemical therapy
FR2709670B1 (fr) * 1993-09-10 1995-10-20 Asulab Sa Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse.
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5795321A (en) * 1994-09-30 1998-08-18 Becton Dickinson And Company Iontophoretic drug delivery system, including removable controller
JP2001520527A (ja) * 1994-09-30 2001-10-30 ベクトン・ディッキンソン・アンド・カンパニー 使い捨てパッチと再使用可能で取り外し可能なコントローラーとを包含するイオン導入式薬物投与系
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CA2233068A1 (en) * 1995-09-28 1997-04-03 Vyteris, Inc. Iontophoretic drug delivery system, including disposable patch
ZA9610374B (en) * 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US6175763B1 (en) 1996-03-29 2001-01-16 Alza Corporation Electrotransport drug delivery device having tactile signaling means
EP0920345A4 (en) * 1996-06-19 2006-05-10 Vyteris Inc IONTOPHORETIC ADMINISTRATION OF CELL ADHESION INHIBITORS
JP4114087B2 (ja) * 1996-11-21 2008-07-09 クロスジェクト 医薬経皮吸収投与装置のリザーバを充填する小型弁
FR2756032B1 (fr) * 1996-11-21 1999-02-05 Lhd Lab Hygiene Dietetique Vanne miniature et son procede de fabrication, dispositif de remplissage de reservoir comprenant une telle vanne
DE29700578U1 (de) * 1997-01-15 1997-03-20 Baermann Horst Rheinmagnet Pflaster zur transdermalen Applikation von Wirkstoffen
US6119036A (en) * 1997-03-26 2000-09-12 The Board Of Regents Of The University Of Oklahoma Iontophoretic transdermal delivery device
DE69829287T2 (de) 1997-06-30 2006-04-13 Centre National De La Recherche Scientifique (Cnrs) Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
EP0991426B2 (fr) 1997-06-30 2007-03-28 Institut Gustave Roussy Procede de transfert d'acide nucleique dans le muscle strie
FR2778108B1 (fr) * 1998-04-30 2000-07-21 Lhd Lab Hygiene Dietetique Dispositif d'administration transdermique de medicament par ionophorese
EP0970719A3 (en) 1998-07-08 2000-08-23 Nitto Denko Corporation Electrode structure
EP1115454B1 (en) * 1998-08-31 2006-10-25 Travanti Pharma Inc Controlled dosage drug delivery system
MXPA01007996A (es) * 1999-02-10 2004-03-26 Gmp Drug Delivery Inc Parches de iontoforesis, electroporacion y combinacion para entrega local de droga..
JP2000300682A (ja) * 1999-04-23 2000-10-31 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用デバイス
US6421561B1 (en) 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
DE10015928B4 (de) * 2000-03-30 2004-12-09 Hafner, Dieter, Dr. Träger für ein Arzneimittel und Verfahren zur Überprüfung der Unversehrtheit dieses Trägers
US6653014B2 (en) 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
TR200200942A2 (tr) * 2002-04-08 2004-02-23 Tuncer De��M �. Üre ölçer/üre saati:insan kanındaki ürenin ters iyontoforez ile, kan veya biyolojik örnek alınmadan tespiti.
US7483736B2 (en) * 2002-04-24 2009-01-27 Rocky Mountain Biosystems, Inc. Feedback control device for transcutaneous drug delivery and uses therefor
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
JP2004202057A (ja) * 2002-12-26 2004-07-22 Tokuyama Corp イオン性薬剤封入袋状物
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
JP4721902B2 (ja) * 2003-12-26 2011-07-13 久光製薬株式会社 用時活性化型イオントフォレーシスデバイス
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US8386029B2 (en) 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
US20070224055A1 (en) 2005-11-23 2007-09-27 Anex Deon S Electrokinetic pump designs and drug delivery systems
AU2007233231B2 (en) 2006-03-30 2011-02-24 Mannkind Corporation Multi-cartridge fluid delivery device
CN101707872B (zh) 2007-04-27 2014-10-22 回声治疗有限公司 用于分析物感测或经皮给药的皮肤渗透装置
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
ES2454974T3 (es) * 2007-06-27 2014-04-14 The General Hospital Corporation Aparato para la inhibición óptica de la terapia fotodinámica
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
EP2100850A1 (en) * 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles
CA2834708A1 (en) 2011-05-05 2012-11-08 Eksigent Technologies, Llc Gel coupling for electrokinetic delivery systems
EP2874693A1 (en) * 2012-07-20 2015-05-27 Grünenthal GmbH Electric-field assisted administration of tapentadol
WO2014115183A1 (ja) * 2013-01-23 2014-07-31 テルモ株式会社 薬剤投与装置および制御方法
KR101697078B1 (ko) * 2015-02-04 2017-01-17 이태규 디지털 바이오 패치
WO2018159865A1 (ko) * 2017-02-28 2018-09-07 주식회사 강앤박메디컬 무 바늘 용액 주입 장치 및 이를 이용한 무 바늘 용액 주입 방법

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US588479A (en) * 1897-08-17 Atjguste roedel
FR16965E (fr) * 1913-05-26 Eugene Morisot Compresse électrique destinée à l'ionisation lente des médicaments à travers les tissus (ioniphore cataphorique)
US486902A (en) * 1892-11-29 Galvanic body-battery
US385567A (en) * 1888-07-03 Chables d
US2493155A (en) * 1947-01-09 1950-01-03 Mine Safety Appliances Co Apparatus for treating skin diseases
US2667162A (en) * 1950-05-03 1954-01-26 Zwahlen Henry Device permitting the ambulatory ionization of blood circulatory troubles of the lower limbs
US2784715A (en) * 1953-03-25 1957-03-12 Kestler Otto Colman Cataphoresis unit
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3289671A (en) * 1963-09-11 1966-12-06 Troutman Edwin Glenn Iontophoresis method
US3547107A (en) * 1968-02-27 1970-12-15 Robert L Chapman Chest mounted heart tachycardia detector
FR2263792A1 (en) * 1974-03-12 1975-10-10 Bondivenne Jean Ionotherapy current generator - comprises thin flexible bag giving percutaneous medicament penetration
US4008721A (en) * 1975-04-14 1977-02-22 Medtronic, Inc. Tape electrode for transmitting electrical signals through the skin
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4164226A (en) * 1976-08-25 1979-08-14 Robert Tapper Iontophoretic burn-protection electrode structure
US4325367A (en) * 1977-06-13 1982-04-20 Robert Tapper Iontophoretic treatment apparatus
US4273135A (en) * 1977-08-19 1981-06-16 Minnesota Mining And Manufacturing Company Biomedical electrode
CA1164710A (en) * 1978-05-09 1984-04-03 Edward J. Reardon, Jr. Phototropic photosensitive compositions containing fluoran colorformer
US4239046A (en) * 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4243052A (en) * 1979-01-08 1981-01-06 Stimtech, Inc. Disposable electrode
US4357557A (en) * 1979-03-16 1982-11-02 Sharp Kabushiki Kaisha Glass sealed thin-film electroluminescent display panel free of moisture and the fabrication method thereof
US4314554A (en) * 1979-07-16 1982-02-09 Greatbatch W Tissue growth control apparatus and method
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
US4367745A (en) * 1980-05-27 1983-01-11 Minnesota Mining And Manufacturing Company Conformable electrically conductive compositions
US4419091A (en) * 1981-02-12 1983-12-06 Sybron Corporation Metalized medical treatment electrode with insulated edge
FR2500689A3 (fr) * 1981-02-20 1982-08-27 Faiveley Sa Generateur de courant unidirectionnel pour l'electrologie
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
EP0060452B1 (en) * 1981-03-05 1985-10-23 Medtronic, Inc. Iontophoretic device
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
JPS58130054A (ja) * 1982-01-29 1983-08-03 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
EP0092015A1 (fr) * 1982-04-16 1983-10-26 Roland Brodard Dispositif d'ionisation
JPS59118167A (ja) * 1982-12-24 1984-07-07 株式会社アドバンス イオントフオレ−ゼ用導子並びに同プラスタ−構造体
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament

Also Published As

Publication number Publication date
DE3588190D1 (de) 1998-08-27
EP0178601B1 (en) 1993-08-11
BR8504939A (pt) 1986-07-22
US4713050A (en) 1987-12-15
WO1986002277A1 (en) 1986-04-24
EP0178601A3 (en) 1987-08-19
ATE92775T1 (de) 1993-08-15
EP0178601A2 (en) 1986-04-23
MX161423A (es) 1990-09-24
KR940000071B1 (ko) 1994-01-05
AR241261A1 (es) 1992-04-30
US4622031A (en) 1986-11-11
EP0197937A1 (en) 1986-10-22
CA1226777A (en) 1987-09-15
AU3935285A (en) 1986-05-02
JPS61100264A (ja) 1986-05-19
KR860003029A (ko) 1986-05-19
EP0513879A3 (it) 1995-02-22
EP0513879B1 (en) 1998-07-22
AU580585B2 (en) 1989-01-19
DE3587518T2 (de) 1993-12-02
EP0513879A2 (en) 1992-11-19
ATE168570T1 (de) 1998-08-15
DE3587518D1 (de) 1993-09-16
DE3588190T2 (de) 1999-02-04
IT8547685A0 (it) 1985-02-14

Similar Documents

Publication Publication Date Title
IT1186798B (it) Applicatore di farmaci trans-cutaneo
DK312884A (da) Applicator
ATA334085A (de) Wimpernschminke
IS3048A7 (is) Læknisfræðilegt úðunartæki
MX163620B (es) Hisopo aplicador mejorado
GB8427770D0 (en) Applying drug solution
BR8605408A (pt) Rolete aplicador
BR8605553A (pt) Aplicador vibratorio
DK336184A (da) Medikamentapplikator
BR8500011A (pt) Dentifricio
KR900000161U (ko) 도포구
IS1371B6 (is) Lyfjaskammtari
DK172986D0 (da) Applikator
NO863770D0 (no) Applikator.
KR860004640A (ko) 전기치료구
BR8801521A (pt) Aplicador
FR2603809B1 (fr) Applicateur nasal
NO168282C (no) Tannpleiemiddel
AU93949S (en) Medicinal applicator
AU93948S (en) Medicinal applicator
ES290841Y (es) Clavo perfeccionado
TR24473A (tr) Kozmetik emilsiyon
AU93950S (en) Medicinal applicator
KR890006457U (ko) 액상물 도포구
BR8400117A (pt) Dispositivo aplicador de medicamentos

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980225