CA1202587A - Semi-synthetic preparation of human insulin - Google Patents

Semi-synthetic preparation of human insulin

Info

Publication number
CA1202587A
CA1202587A CA000426236A CA426236A CA1202587A CA 1202587 A CA1202587 A CA 1202587A CA 000426236 A CA000426236 A CA 000426236A CA 426236 A CA426236 A CA 426236A CA 1202587 A CA1202587 A CA 1202587A
Authority
CA
Canada
Prior art keywords
insulin
human insulin
des
residue
bonding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000426236A
Other languages
English (en)
French (fr)
Inventor
Gijsbert W. K. Van Dedem
Francois E. A. Van Houdenhoven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of CA1202587A publication Critical patent/CA1202587A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA000426236A 1982-04-21 1983-04-20 Semi-synthetic preparation of human insulin Expired CA1202587A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8201650A NL8201650A (nl) 1982-04-21 1982-04-21 Semisynthetische bereiding van humane insuline.
NL8201650 1982-04-21

Publications (1)

Publication Number Publication Date
CA1202587A true CA1202587A (en) 1986-04-01

Family

ID=19839621

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000426236A Expired CA1202587A (en) 1982-04-21 1983-04-20 Semi-synthetic preparation of human insulin

Country Status (15)

Country Link
US (1) US4840897A (enExample)
EP (1) EP0092280B1 (enExample)
JP (2) JPS58189149A (enExample)
AT (1) ATE42203T1 (enExample)
AU (1) AU554050B2 (enExample)
CA (1) CA1202587A (enExample)
DE (1) DE3379640D1 (enExample)
DK (1) DK173007B1 (enExample)
ES (1) ES8405760A1 (enExample)
HU (1) HU189268B (enExample)
IL (1) IL68397A (enExample)
NL (1) NL8201650A (enExample)
PL (1) PL143571B1 (enExample)
SU (1) SU1232148A3 (enExample)
ZA (1) ZA832602B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK309184D0 (da) * 1984-06-25 1984-06-25 Nordisk Insulinlab Fremgangsmaade til isolering af insulin eller insulinlignende materiale fra en fermenteringsvaeske
SI0792290T1 (en) * 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
CN113956326B (zh) * 2021-09-15 2024-05-28 河南工业大学 一种短肽单体，结构自愈型肽基水凝胶及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten

Also Published As

Publication number Publication date
US4840897A (en) 1989-06-20
SU1232148A3 (ru) 1986-05-15
JPH05339290A (ja) 1993-12-21
DK173007B1 (da) 1999-11-08
NL8201650A (nl) 1983-11-16
JPS58189149A (ja) 1983-11-04
AU554050B2 (en) 1986-08-07
JPH0533993B2 (enExample) 1993-05-20
ES521674A0 (es) 1984-06-16
AU1355483A (en) 1983-10-27
EP0092280B1 (en) 1989-04-19
HU189268B (en) 1986-06-30
IL68397A0 (en) 1983-07-31
DE3379640D1 (en) 1989-05-24
IL68397A (en) 1986-01-31
PL241575A1 (en) 1983-12-19
EP0092280A1 (en) 1983-10-26
PL143571B1 (en) 1988-02-29
ZA832602B (en) 1984-01-25
ATE42203T1 (de) 1989-05-15
DK161683A (da) 1983-10-22
DK161683D0 (da) 1983-04-13
JPH0735399B2 (ja) 1995-04-19
ES8405760A1 (es) 1984-06-16

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