CA1197237A - Daunorubicin and doxorubicin analogues, their preparation and use thereof - Google Patents

Daunorubicin and doxorubicin analogues, their preparation and use thereof

Info

Publication number
CA1197237A
CA1197237A CA000419718A CA419718A CA1197237A CA 1197237 A CA1197237 A CA 1197237A CA 000419718 A CA000419718 A CA 000419718A CA 419718 A CA419718 A CA 419718A CA 1197237 A CA1197237 A CA 1197237A
Authority
CA
Canada
Prior art keywords
methyl
demethoxy
daunorubicin
doxorubicin
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000419718A
Other languages
English (en)
French (fr)
Inventor
Federico Arcamone
Giuliano Franchi
Sergio Penco
Anna M. Casazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of CA1197237A publication Critical patent/CA1197237A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA000419718A 1982-01-26 1983-01-18 Daunorubicin and doxorubicin analogues, their preparation and use thereof Expired CA1197237A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8202080 1982-01-26
GB8202080 1982-01-26

Publications (1)

Publication Number Publication Date
CA1197237A true CA1197237A (en) 1985-11-26

Family

ID=10527864

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000419718A Expired CA1197237A (en) 1982-01-26 1983-01-18 Daunorubicin and doxorubicin analogues, their preparation and use thereof

Country Status (28)

Country Link
JP (1) JPS58128396A (ru)
KR (1) KR900006214B1 (ru)
AT (1) AT378776B (ru)
AU (1) AU551700B2 (ru)
BE (1) BE895687A (ru)
CA (1) CA1197237A (ru)
CH (1) CH657622A5 (ru)
CS (1) CS235979B2 (ru)
DE (1) DE3301489A1 (ru)
DK (1) DK157322C (ru)
ES (1) ES519255A0 (ru)
FI (1) FI74977C (ru)
FR (1) FR2520365B1 (ru)
GB (1) GB2116169B (ru)
GR (1) GR77890B (ru)
HU (1) HU192784B (ru)
IE (1) IE53750B1 (ru)
IL (1) IL67709A (ru)
IT (1) IT1210482B (ru)
NL (1) NL8300150A (ru)
NO (1) NO153456C (ru)
NZ (1) NZ203047A (ru)
PH (1) PH19130A (ru)
PT (1) PT76113A (ru)
SE (1) SE461591B (ru)
SU (1) SU1187724A3 (ru)
YU (1) YU43536B (ru)
ZA (1) ZA83450B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
GB8708927D0 (en) * 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
GB1573037A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
ATE4387T1 (de) * 1979-07-04 1983-08-15 Farmitalia Carlo Erba S.P.A. Anthracyclin-glycoside, verfahren zu ihrer herstellung und sie enthaltende therapeutische zusammensetzung.
DE3100968A1 (de) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
IT8319147A0 (it) 1983-01-18
NO830234L (no) 1983-07-27
NZ203047A (en) 1985-10-11
JPS58128396A (ja) 1983-07-30
BE895687A (fr) 1983-05-16
ZA83450B (en) 1983-10-26
NO153456B (no) 1985-12-16
IE53750B1 (en) 1989-02-01
GB8301178D0 (en) 1983-02-16
YU8983A (en) 1986-02-28
DE3301489C2 (ru) 1988-01-28
CS235979B2 (en) 1985-05-15
DK157322B (da) 1989-12-11
SE8300324D0 (sv) 1983-01-21
AT378776B (de) 1985-09-25
NL8300150A (nl) 1983-08-16
YU43536B (en) 1989-08-31
NO153456C (no) 1986-03-26
ES8403140A1 (es) 1984-03-01
DK27683A (da) 1983-07-27
KR900006214B1 (ko) 1990-08-25
FI74977B (fi) 1987-12-31
GB2116169A (en) 1983-09-21
SE461591B (sv) 1990-03-05
FI830155L (fi) 1983-07-27
JPS6328436B2 (ru) 1988-06-08
ATA15683A (de) 1985-02-15
ES519255A0 (es) 1984-03-01
IE830144L (en) 1983-07-26
FI830155A0 (fi) 1983-01-17
KR840003262A (ko) 1984-08-20
SE8300324L (sv) 1983-07-27
DK27683D0 (da) 1983-01-25
IL67709A0 (en) 1983-05-15
GB2116169B (en) 1985-09-04
IL67709A (en) 1986-03-31
DK157322C (da) 1990-05-07
AU1052583A (en) 1983-08-04
HU192784B (en) 1987-07-28
PT76113A (en) 1983-02-01
CH657622A5 (it) 1986-09-15
AU551700B2 (en) 1986-05-08
FR2520365B1 (fr) 1985-07-12
PH19130A (en) 1986-01-08
SU1187724A3 (ru) 1985-10-23
IT1210482B (it) 1989-09-14
FI74977C (fi) 1988-04-11
DE3301489A1 (de) 1983-08-04
GR77890B (ru) 1984-09-25
FR2520365A1 (fr) 1983-07-29

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry