CA1115212A - Pyrrolidine derivatives - Google Patents

Pyrrolidine derivatives

Info

Publication number
CA1115212A
CA1115212A CA319,572A CA319572A CA1115212A CA 1115212 A CA1115212 A CA 1115212A CA 319572 A CA319572 A CA 319572A CA 1115212 A CA1115212 A CA 1115212A
Authority
CA
Canada
Prior art keywords
methoxybenzyl
formula
test
medicament
dosage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA319,572A
Other languages
English (en)
French (fr)
Inventor
Emilio Kyburz
Werner Aschwanden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1115212A publication Critical patent/CA1115212A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA319,572A 1978-02-10 1979-01-12 Pyrrolidine derivatives Expired CA1115212A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140478 1978-02-10
CH1404/78 1978-02-10

Publications (1)

Publication Number Publication Date
CA1115212A true CA1115212A (en) 1981-12-29

Family

ID=4209637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA319,572A Expired CA1115212A (en) 1978-02-10 1979-01-12 Pyrrolidine derivatives

Country Status (12)

Country Link
US (2) US4239770A (enExample)
EP (1) EP0003602B1 (enExample)
JP (1) JPS54117469A (enExample)
AU (1) AU525204B2 (enExample)
CA (1) CA1115212A (enExample)
DE (1) DE2967324D1 (enExample)
IE (1) IE48897B1 (enExample)
IL (1) IL56577A (enExample)
MC (1) MC1258A1 (enExample)
NZ (1) NZ189572A (enExample)
PH (1) PH14270A (enExample)
ZA (1) ZA79452B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1124247A (en) * 1979-08-09 1982-05-25 Hoffmann-La Roche Limited Pyrrolidine derivatives
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
US4431662A (en) * 1981-03-06 1984-02-14 Hodgson Gordon L Jun 1-(1,3-Benzodioxol-5-yl)-2-pyrrolidinone and its medicinal use
EP0106988A1 (en) * 1982-09-02 1984-05-02 The Wellcome Foundation Limited Pharmacologically active lactam derivatives
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3706399A1 (de) * 1987-02-27 1988-09-08 Boehringer Ingelheim Kg Mittel mit antidepressiver wirkung
IT1215587B (it) * 1987-06-26 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale.
IT1231921B (it) * 1989-06-12 1992-01-15 Sigma Tau Ind Farmaceuti 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
JP2803882B2 (ja) * 1990-02-20 1998-09-24 日清製粉株式会社 １―フエノキシカルボニル―２―ピロリジノン誘導体
IT1242043B (it) * 1990-12-21 1994-02-02 Sigma Tau Ind Farmaceuti Derivati della 1,2,3,4,-tetraidronaftilammina ad attivita' nootropica e composizioni farmaceutiche che li contengono.
US5780375A (en) * 1993-10-19 1998-07-14 E. I. Du Pont De Nemours And Company Thick film composition for modifying the electrical properties of a dielectric layer
RS57541B1 (sr) * 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2915430A (en) * 1958-09-30 1959-12-01 Gen Aniline & Film Corp Method of controlling nematodes with n-acylpyrrolidones
GB1039113A (en) 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
ES425600A1 (es) * 1974-04-23 1977-01-16 Lafarquim Procedimiento de obtencion de un nuevo derivado de pirroli- dinona.
FR2294698A1 (fr) * 1974-12-18 1976-07-16 Synthelabo Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
ES433723A1 (es) * 1975-01-10 1976-11-16 Lafarquim S A Lab Procedimiento de obtencion de un derivado de 2-pirrolidi- nona.
DE2616374A1 (de) * 1976-04-14 1977-10-27 Bayer Ag In 4-stellung amidoalkylierte phenole

Also Published As

Publication number Publication date
AU525204B2 (en) 1982-10-28
AU4388979A (en) 1979-08-16
IE790245L (en) 1979-08-10
NZ189572A (en) 1985-01-31
IL56577A0 (en) 1979-05-31
MC1258A1 (fr) 1980-01-14
IE48897B1 (en) 1985-06-12
JPS6210206B2 (enExample) 1987-03-05
IL56577A (en) 1982-07-30
DE2967324D1 (en) 1985-01-24
PH14270A (en) 1981-04-29
ZA79452B (en) 1980-02-27
EP0003602A1 (de) 1979-08-22
EP0003602B1 (de) 1984-12-12
US4349562A (en) 1982-09-14
US4239770A (en) 1980-12-16
JPS54117469A (en) 1979-09-12

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Legal Events

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