CA1114761A - Production of urokinase - Google Patents

Production of urokinase

Info

Publication number
CA1114761A
CA1114761A CA328,201A CA328201A CA1114761A CA 1114761 A CA1114761 A CA 1114761A CA 328201 A CA328201 A CA 328201A CA 1114761 A CA1114761 A CA 1114761A
Authority
CA
Canada
Prior art keywords
urokinase
medium
cells
phenylalanine
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA328,201A
Other languages
English (en)
French (fr)
Inventor
Mau-Jung Kuo
Margaret J. Reents
Joseph Feder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of CA1114761A publication Critical patent/CA1114761A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CA328,201A 1978-05-24 1979-05-23 Production of urokinase Expired CA1114761A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/909,137 US4190708A (en) 1978-05-24 1978-05-24 Production of urokinase
US909,137 1978-05-24

Publications (1)

Publication Number Publication Date
CA1114761A true CA1114761A (en) 1981-12-22

Family

ID=25426682

Family Applications (1)

Application Number Title Priority Date Filing Date
CA328,201A Expired CA1114761A (en) 1978-05-24 1979-05-23 Production of urokinase

Country Status (10)

Country Link
US (1) US4190708A (enExample)
EP (1) EP0005644B1 (enExample)
JP (1) JPS54163887A (enExample)
AU (1) AU522609B2 (enExample)
CA (1) CA1114761A (enExample)
DE (1) DE2965182D1 (enExample)
DK (1) DK152138C (enExample)
HU (1) HU179549B (enExample)
MX (1) MX5901E (enExample)
SU (1) SU927126A3 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
US4659655A (en) * 1981-11-25 1987-04-21 Bio-Response, Inc. Method for isolating product-producing cells
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).
FI831484A7 (fi) 1982-05-05 1983-11-06 Genentech Inc Ihmiskudoksen plasminogeenien aktivaattori.
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
US5011795A (en) 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
US5132214A (en) * 1986-04-09 1992-07-21 Monsanto Company Large scale production of plasminogen activator from normal human colon cells
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
JP2548915Y2 (ja) * 1991-04-02 1997-09-24 カヤバ工業株式会社 重量物の支持装置
CN110607272B (zh) * 2019-09-23 2022-11-01 山东甲骨文生物科技有限公司 一种哺乳动物细胞培养液的添加剂及细胞培养液

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930945A (en) * 1956-08-16 1960-03-29 Vickers Inc Power transmission
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
US3930944A (en) * 1975-03-31 1976-01-06 Abbott Laboratories Urokinase production
AR208001A1 (es) * 1975-03-31 1976-11-22 Abbott Lab Procedimiento mejorado para la produccion de uroquinasa

Also Published As

Publication number Publication date
DK212079A (da) 1979-11-25
DE2965182D1 (en) 1983-05-19
MX5901E (es) 1984-08-22
EP0005644A2 (en) 1979-11-28
EP0005644B1 (en) 1983-04-13
JPS629319B2 (enExample) 1987-02-27
HU179549B (en) 1982-11-29
EP0005644A3 (en) 1979-12-12
US4190708A (en) 1980-02-26
DK152138C (da) 1988-08-08
JPS54163887A (en) 1979-12-26
SU927126A3 (ru) 1982-05-07
DK152138B (da) 1988-02-01
AU4734379A (en) 1979-11-29
AU522609B2 (en) 1982-06-17

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19981222