CA1111763A - Lipophilic particles non-covalently bonded to label and ligand for binding assay - Google Patents

Lipophilic particles non-covalently bonded to label and ligand for binding assay

Info

Publication number
CA1111763A
CA1111763A CA322,766A CA322766A CA1111763A CA 1111763 A CA1111763 A CA 1111763A CA 322766 A CA322766 A CA 322766A CA 1111763 A CA1111763 A CA 1111763A
Authority
CA
Canada
Prior art keywords
ligand
label
lipophilic
analyte
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA322,766A
Other languages
English (en)
French (fr)
Inventor
Edwin F. Ullman
John M. Brinkley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syva Co
Original Assignee
Syva Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syva Co filed Critical Syva Co
Application granted granted Critical
Publication of CA1111763A publication Critical patent/CA1111763A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/819—Multifunctional antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA322,766A 1978-05-16 1979-03-05 Lipophilic particles non-covalently bonded to label and ligand for binding assay Expired CA1111763A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/906,514 US4193983A (en) 1978-05-16 1978-05-16 Labeled liposome particle compositions and immunoassays therewith
US906,514 1986-09-12

Publications (1)

Publication Number Publication Date
CA1111763A true CA1111763A (en) 1981-11-03

Family

ID=25422574

Family Applications (1)

Application Number Title Priority Date Filing Date
CA322,766A Expired CA1111763A (en) 1978-05-16 1979-03-05 Lipophilic particles non-covalently bonded to label and ligand for binding assay

Country Status (6)

Country Link
US (1) US4193983A (enExample)
JP (1) JPS54151097A (enExample)
CA (1) CA1111763A (enExample)
DE (1) DE2919835A1 (enExample)
FR (1) FR2426261A1 (enExample)
GB (1) GB2021262B (enExample)

Families Citing this family (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4374925A (en) * 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4351760A (en) * 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
GB2059421A (en) * 1979-10-03 1981-04-23 Self C H Assay method and reagents therefor
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
NL8000173A (nl) * 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
JPS56132564A (en) * 1980-02-04 1981-10-16 Koraboreiteibu Research Inc Product for and method of immunity analysis
US4342826A (en) * 1980-02-04 1982-08-03 Collaborative Research, Inc. Immunoassay products and methods
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4343895A (en) * 1980-05-23 1982-08-10 Stephen Sugaar Encapsulated antigenic tumor specific substances and methods for detecting cancer using said substances
JPS5719662A (en) * 1980-07-09 1982-02-01 Fuji Photo Film Co Ltd Preparation of microcapsule reagent for immune reaction
JPS5719660A (en) * 1980-07-09 1982-02-01 Fuji Photo Film Co Ltd Microcapsule for immune reaction
DE3132491A1 (de) * 1980-08-22 1982-07-01 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Verfahren zur durchfuehrung analytischer bestimmungen mittels der chemilumineszenzmethode und anwendung des verfahrens fuer immunassays
US4407964A (en) * 1980-10-07 1983-10-04 The Regents Of The University Of California Homogeneous fluoroimmunoassay involving sensing radiation for forward and back directions
DE3143423C2 (de) 1980-12-22 1984-08-30 Bernd Dr. 8000 München Frenzel Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen
EP0054952B1 (de) * 1980-12-22 1984-10-10 Seromed medizinische Vertriebs GmbH Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen
WO1982002252A1 (en) * 1980-12-22 1982-07-08 Frenzel Bernd Method for the determination of antigens,antibodies and their complexes
DE3152832C2 (de) * 1980-12-22 1985-02-14 Bernd Dr. 8000 München Frenzel Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen
US4483921A (en) * 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
JPS58500084A (ja) * 1981-02-10 1983-01-13 エレクトロ−ヌクレオニツクス，インコ−ポレ−テツド 免疫化学のための化学ルミネセンス増巾基質システム
AU555213B2 (en) * 1981-02-17 1986-09-18 Abbott Laboratories N-substituted-amido-fluoresein derivatives
US4378428A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays
US4785080A (en) * 1981-03-30 1988-11-15 Baker Instruments Corporation Labeled analytes
IT1140209B (it) * 1981-09-25 1986-09-24 Anic Spa Reagenti per immunoluorescenza e metodo per la loro preparazione
US4463090A (en) * 1981-09-30 1984-07-31 Harris Curtis C Cascade amplification enzyme immunoassay
US5055556A (en) * 1981-10-06 1991-10-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Fluorescent conjugates for analysis of molecules and cells
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
US4659655A (en) * 1981-11-25 1987-04-21 Bio-Response, Inc. Method for isolating product-producing cells
US4429008B1 (en) * 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
FR2518451A1 (fr) * 1981-12-23 1983-06-24 Allibert Sa Procede de fabrication d'un couvercle de recipient pourvu d'un bec verseur escamotable et moule pour la mise en oeuvre de ce procede
WO1983003473A1 (en) * 1982-03-26 1983-10-13 Liposome Co Inc Lupus assay method and compositions
US5441745A (en) * 1982-03-30 1995-08-15 Vestar, Inc. Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US5435989A (en) * 1982-03-30 1995-07-25 Vestar, Inc. Method of targeting a specific location in a body
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4663278A (en) * 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
US4483929A (en) * 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
AU567693B2 (en) * 1982-09-30 1987-12-03 University Of Rochester Human monoclonal antibodies against bacterial toxins
US4689299A (en) * 1982-09-30 1987-08-25 University Of Rochester Human monoclonal antibodies against bacterial toxins
US4550017A (en) * 1982-10-15 1985-10-29 Syntex (U.S.A.) Inc. Fluorescence screening for blood typing
US4588698A (en) * 1982-10-19 1986-05-13 University Patents, Inc. Encapsulated scintillators for measuring the concentration of tritiated solutes
US4517303A (en) * 1982-10-20 1985-05-14 E. I. Du Pont De Nemours And Company Specific binding assays utilizing analyte-cytolysin conjugates
WO1984002579A1 (en) * 1982-12-23 1984-07-05 Cooper Lipotech Inc Lipid-vesicle-surface assay reagent and method
US4501728A (en) * 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4668638A (en) * 1983-03-24 1987-05-26 The Liposome Company, Inc. Liposome composition for lupus assay
US4614796A (en) * 1983-03-25 1986-09-30 Nippon Shinyaku Co., Ltd. Liposome and method of manufacture therefor
US4636479A (en) * 1983-04-20 1987-01-13 Cooper-Lipotech, Inc. Enhanced agglutination method and kit
US4605630A (en) * 1983-07-27 1986-08-12 Cooper Lipotech Inc. Large-liposome agglutination reagent and method
US4640898A (en) * 1983-08-01 1987-02-03 University Of Health Sciences/The Chicago Medical School Homogeneous fluorescence ligang binding assay based upon preferential alteration of the respective intensities of bound and free label by solvent components
US4713324A (en) * 1983-09-01 1987-12-15 Technicon Instruments Corporation Inverted latency specific binding assay
MX9203290A (es) * 1983-09-19 1992-08-01 Liposome Co Inc Suministro localizado usando conjugados de fibronectina.
JPH06100601B2 (ja) * 1983-11-30 1994-12-12 株式会社東芝 免疫分析用試薬及びそれを用いた分析方法
US4708929A (en) * 1984-10-29 1987-11-24 Microgenics Corporation Methods for protein binding enzyme complementation assays
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes
US5231112A (en) 1984-04-12 1993-07-27 The Liposome Company, Inc. Compositions containing tris salt of cholesterol hemisuccinate and antifungal
US4891208A (en) * 1985-04-10 1990-01-02 The Liposome Company, Inc. Steroidal liposomes
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4708933A (en) * 1984-06-12 1987-11-24 Leaf Huang Immunoliposome assay-methods and products
US4957735A (en) * 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4666830A (en) * 1984-08-23 1987-05-19 Wagner Daniel B Assay employing sacs and sac lysing agent
US4839276A (en) * 1984-12-05 1989-06-13 Technicon Instruments Corporation Interference - resistant liposome specific binding assay
US5106963A (en) * 1984-12-28 1992-04-21 Miles, Inc., Successor In Interest To Technicon Instruments Corp. Phospholipid conjugates and their preparation
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
US4704355A (en) * 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
US4707453A (en) * 1985-04-05 1987-11-17 Becton Dickinson And Company Vesicle including a metal marker for use in an assay
US4698263A (en) * 1985-05-23 1987-10-06 Becton Dickinson And Company Sac having a marker linked thereto
US4828982A (en) * 1985-05-28 1989-05-09 Becton, Dickinson & Company Vesticles and use thereof in an enzyme assay
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US5409704A (en) * 1985-06-26 1995-04-25 The Liposome Company, Inc. Liposomes comprising aminoglycoside phosphates and methods of production and use
US5171578A (en) * 1985-06-26 1992-12-15 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US4752572A (en) * 1985-08-30 1988-06-21 Eastman Kodak Company Lipid vesicles containing labeled species and their analytical uses
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US5041278A (en) * 1985-10-15 1991-08-20 The Liposome Company, Inc. Alpha tocopherol-based vesicles
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US5190864A (en) * 1986-04-15 1993-03-02 Northeastern University Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) * 1986-04-15 1990-06-26 Northeastern University Enzyme activity amplification method for increasing assay sensitivity
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5120504A (en) * 1986-07-14 1992-06-09 Hybritech Incorporated Apparatus for immunoassays with vent chennels in the container side wall
US4859538A (en) * 1986-11-20 1989-08-22 Ribi Hans O Novel lipid-protein compositions and articles and methods for their preparation
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5346670A (en) * 1986-12-24 1994-09-13 British Technology Group U.S.A. Inc. Phthalocyanine and tetrabenztriazaporphyrin reagents
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
IT1206777B (it) * 1987-04-06 1989-05-03 Chemetron Del Dr Del Campo Gio Procedimento di analisi immunologica o chimica per la determinazione di proteine in fluidi biologici e relativo completo (kit) di mezzi analitici.
US4869905A (en) * 1987-05-12 1989-09-26 The B. F. Goodrich Company Method of making and a slow release composition for abating acid water formation
US5227489A (en) * 1988-08-01 1993-07-13 Ciba Corning Diagnostics Corp. Stable hydrophilic acridinium esters suitable for liposome encapsulation
US4942036A (en) * 1988-08-25 1990-07-17 Blair Geho W Therapy by vesicle delivery to the hydroxyapatite of bone
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
SE466521B (sv) * 1988-10-03 1992-02-24 Kurt G I Nilsson Reagens vid analys bestaaende av ett enzym och en annan ligand, vilka aer kovalent bundna till en vattenoloeslig partikel med en diameter paa mindre aen 500 aa
EP0437479B1 (en) * 1988-10-05 1994-06-22 Vestar, Inc. Method of making liposomes with improved stability during drying
NZ231180A (en) 1988-10-31 1994-11-25 Dow Chemical Co Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof
US5139803A (en) * 1989-02-09 1992-08-18 Nabisco, Inc. Method and liposome composition for the stabilization of oxidizable substances
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
DE69021161T2 (de) * 1989-04-28 1995-11-30 Toray Industries Verfahren zur Bestimmung einer Substanz durch Verwendung von chemilumineszenz.
DE69026380T2 (de) * 1989-06-23 1996-10-17 The Liposome Co.,Inc., Princeton, N.J. Zielliposomen und verfahren zur kupplung von liposomen-proteinen
US5169635A (en) * 1989-11-17 1992-12-08 Fuji Photo Film Co., Ltd. Photoresponsive liposome
AU660288B2 (en) * 1990-07-31 1995-06-22 Transave, Inc. Accumulation of amino acids and peptides into liposomes
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5208148A (en) * 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5567591A (en) * 1991-06-24 1996-10-22 Becton Dickinson And Company Amplified assay for analyte
US5726010A (en) * 1991-07-31 1998-03-10 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
US6007999A (en) * 1991-07-31 1999-12-28 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
US5567432A (en) * 1991-08-02 1996-10-22 Lau; John R. Masking of liposomes from RES recognition
US5279937A (en) * 1992-04-30 1994-01-18 Detechnology Canada Use of macroglobulins to improve the signal-to-background ratio in affinity binding assays
ES2113547T3 (es) * 1992-07-31 1998-05-01 Behringwerke Ag Matrices quimioluminiscentes fotoactivables.
US5354692A (en) * 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
NL9201722A (nl) * 1992-10-05 1994-05-02 Stichting Tech Wetenschapp Farmaceutische samenstelling voor de plaatsgebonden afgifte van een stolsel oplossend eiwit en werkwijze voor de bereiding daarvan.
US5415999A (en) * 1993-07-09 1995-05-16 Biocircuits Corporation Fluorescent lipid polymer-macromolecular ligand compositions as detection element in ligand assays
WO1995021812A1 (en) * 1994-02-14 1995-08-17 Indiana University Foundation Aminophospholipid compositions and uses thereof
GB9406464D0 (en) * 1994-03-31 1994-05-25 British Tech Group Assay for determining biochemical changes at phospholipid bilayer membrane surfaces
US5824292A (en) * 1995-04-12 1998-10-20 Quest International B.V. Oral care compositions
US5795453A (en) * 1996-01-23 1998-08-18 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5830341A (en) * 1996-01-23 1998-11-03 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5770086A (en) * 1996-01-25 1998-06-23 Eureka| Science Corp. Methods and apparatus using hydrogels
US5776487A (en) * 1996-04-19 1998-07-07 Pasteur Sanofi Diagnostics Liposome reagents for immunoassays
US5780319A (en) * 1996-04-19 1998-07-14 Pasteur Sanofi Diagnostics Immunoassays to detect antiphospholipid antibodies
AU702976B2 (en) * 1996-05-03 1999-03-11 Roger S. Cubicciotti Prodrug compositions and drug delivery methods using synthetic receptors
US6375930B2 (en) * 1996-06-04 2002-04-23 Board Of Regents, The University Of Texas System Membrane incorporation of texaphyrins
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6054133A (en) * 1997-07-10 2000-04-25 The Regents Of The University Of California Anti-microbial targeting for intracellular pathogens
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
AU2679899A (en) 1998-02-18 1999-09-06 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
AU751938B2 (en) * 1998-05-15 2002-08-29 Sekisui Chemical Co., Ltd. Immunoassay reagents and immunoassay method
EP2000803A1 (en) 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoparticles with Polymer Shells
EP1294930B1 (en) * 2000-01-13 2011-03-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
JP2001208754A (ja) * 2000-01-26 2001-08-03 Kazunori Kataoka 生物学的な被検体を検出するための組成物
ATE324465T1 (de) * 2000-07-11 2006-05-15 Univ Northwestern Nachweismethode mittels verstärkter silberfärbung
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
WO2002096262A2 (en) * 2001-05-25 2002-12-05 Northwestern University Non-alloying core shell nanoparticles
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CA2466656C (en) 2001-11-09 2013-07-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
FR2836066B1 (fr) * 2002-02-21 2004-11-26 Centre Nat Rech Scient Chaines colloidales irreversibles porteuses de sites de reconnaissance, leur procede de preparation et application a des fins de detection d'especes
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
WO2004004647A2 (en) * 2002-07-02 2004-01-15 Nanosphere Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
US7125722B2 (en) * 2002-07-03 2006-10-24 Abbott Laboratories Apparatus and method for handling fluids for analysis
WO2004038369A2 (en) * 2002-10-21 2004-05-06 Discoverx, Inc. Ip3 protein binding assay
CL2004000016A1 (es) * 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
WO2005001143A2 (en) * 2003-02-27 2005-01-06 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
JP2007521021A (ja) * 2003-11-06 2007-08-02 ディスカヴァーエックス インコーポレイテッド 細胞膜タンパク質の検定
CA2571730C (en) * 2004-06-30 2013-08-20 Joseph Horecka Analysis of intracellular modifications
WO2006028601A2 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture
US8029985B2 (en) * 2004-09-01 2011-10-04 Vybion, Inc. Amplified bioassay
CA2603814C (en) * 2005-04-18 2013-08-27 Bio-Rad Laboratories, Inc. Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
GB0512769D0 (en) * 2005-06-23 2005-07-27 Avacta Ltd Ratiometic multicolour fluorescence correlation screening; agents for use therewith and methods of production thereof
JP2009505106A (ja) * 2005-08-19 2009-02-05 ナノスフェアー インコーポレイテッド Ｄｎａ及び抗体を含むハイブリッド基板を調製するための方法及びその使用
WO2007050584A2 (en) * 2005-10-24 2007-05-03 Discoverx, Inc. Detection of intracellular enzyme complex
EP1956373B1 (en) * 2005-12-07 2017-01-25 Sekisui Medical Co., Ltd. Method for assaying anti-treponema pallidum antibody
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
FR2908414B1 (fr) 2006-11-13 2012-01-20 Centre Nat Rech Scient Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
RU2517161C2 (ru) 2012-04-02 2014-05-27 Максим Петрович Никитин Способ определения содержания лиганда в образце (варианты)
LV15576A (lv) * 2019-11-28 2021-06-20 Latvijas Organiskās Sintēzes Institūts Fluorescējošie akridīnija sāļi, to sintēze un izmantošana kardiolipīna noteikšanai
LV15619A (lv) * 2020-08-20 2022-02-20 Latvijas Organiskās Sintēzes Institūts Paņēmiens bioloģiski aktīvu savienojumu saistīšanas afinitātes pret kardiolipīnu noteikšanai
CN118914540A (zh) * 2023-05-06 2024-11-08 深圳市新产业生物医学工程股份有限公司 用于检测至少一种抗磷脂抗体的检测试剂、试剂盒及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2127174A5 (enExample) * 1971-02-26 1972-10-13 Inst Nat Sante Rech Med
US3887698A (en) * 1973-03-12 1975-06-03 Univ Leland Stanford Junior Sacs with epitopic sites on walls enclosing stable free radicals
FR2221731B1 (enExample) * 1973-03-12 1978-11-10 Univ Leland Stanford Junior
US3882224A (en) * 1973-09-11 1975-05-06 American Cyanamid Co Reagents and tests for syphilis
US3949065A (en) * 1973-09-11 1976-04-06 American Cyanamid Company Composition and method for the detection of syphilis
US3998943A (en) * 1973-10-02 1976-12-21 Syva Company Double receptor fluorescent immunoassay
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4181650A (en) * 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids

Also Published As

Publication number Publication date
DE2919835A1 (de) 1979-11-22
GB2021262B (en) 1983-02-09
JPS54151097A (en) 1979-11-27
FR2426261A1 (fr) 1979-12-14
US4193983A (en) 1980-03-18
JPS6338666B2 (enExample) 1988-08-01
GB2021262A (en) 1979-11-28

Similar Documents

Publication Publication Date Title
CA1111763A (en) Lipophilic particles non-covalently bonded to label and ligand for binding assay
US6251581B1 (en) Assay method utilizing induced luminescence
EP0984282B1 (en) Particles having an incorporated composition comprising a chemiluminescent compound
US5618732A (en) Method of calibration with photoactivatable chemiluminescent matrices
US7635571B2 (en) Amplified signal in binding assays
US6406667B1 (en) Chemiluminescent compositions for use in detection of multiple analytes
US4708933A (en) Immunoliposome assay-methods and products
US4704355A (en) Assay utilizing ATP encapsulated within liposome particles
US4891324A (en) Particle with luminescer for assays
US5340716A (en) Assay method utilizing photoactivated chemiluminescent label
WO1981002344A1 (en) Immunoassay products and methods
JPS631544B2 (enExample)
CA2425483C (en) Assay method utilizing induced luminescence
US4888288A (en) Vesicles resistant to enzyme lysis and use thereof in an enzyme assay
US4828982A (en) Vesticles and use thereof in an enzyme assay
EP0258388A1 (en) Immunoliposome assay - methods and products
JPS62163966A (ja) 補体価測定用試薬
JPS63158461A (ja) 免疫分析用試薬

Legal Events

Date Code Title Description
MKEX Expiry