CA1110234A - 4-pyridone-3-carboxylic acids and process for the preparation thereof - Google Patents

4-pyridone-3-carboxylic acids and process for the preparation thereof

Info

Publication number
CA1110234A
CA1110234A CA318,702A CA318702A CA1110234A CA 1110234 A CA1110234 A CA 1110234A CA 318702 A CA318702 A CA 318702A CA 1110234 A CA1110234 A CA 1110234A
Authority
CA
Canada
Prior art keywords
group
ethyl
methyl
alkyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA318,702A
Other languages
English (en)
French (fr)
Inventor
Alexander E. Wick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH51278A external-priority patent/CH639073A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1110234A publication Critical patent/CA1110234A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA318,702A 1978-01-18 1978-12-28 4-pyridone-3-carboxylic acids and process for the preparation thereof Expired CA1110234A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH512/78 1978-01-18
CH51278A CH639073A5 (en) 1978-01-18 1978-01-18 4-Pyridone-3-carboxylic acid derivatives and their preparation
CH11734/78 1978-11-15
CH1173478 1978-11-15

Publications (1)

Publication Number Publication Date
CA1110234A true CA1110234A (en) 1981-10-06

Family

ID=25684790

Family Applications (1)

Application Number Title Priority Date Filing Date
CA318,702A Expired CA1110234A (en) 1978-01-18 1978-12-28 4-pyridone-3-carboxylic acids and process for the preparation thereof

Country Status (25)

Country Link
US (2) US4521535A (enExample)
EP (1) EP0003144B1 (enExample)
JP (1) JPS54100382A (enExample)
KR (1) KR820002111B1 (enExample)
AR (1) AR223663A1 (enExample)
AT (1) AT369731B (enExample)
AU (1) AU521148B2 (enExample)
CA (1) CA1110234A (enExample)
DE (1) DE2901868A1 (enExample)
DK (1) DK20279A (enExample)
ES (1) ES476917A1 (enExample)
FI (1) FI790103A7 (enExample)
FR (1) FR2415103A1 (enExample)
GB (1) GB2013190B (enExample)
GR (1) GR73088B (enExample)
HU (1) HU179487B (enExample)
IE (1) IE47784B1 (enExample)
IL (1) IL56421A (enExample)
LU (1) LU80794A1 (enExample)
MC (1) MC1239A1 (enExample)
NL (1) NL7900264A (enExample)
NO (1) NO152089C (enExample)
NZ (1) NZ189379A (enExample)
PT (1) PT69093A (enExample)
SE (1) SE7900318L (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125762A (en) * 1979-07-13 1982-06-15 Alexander E. Wick Dihydronicotinic acid derivatives and process for the preparation thereof
NZ197027A (en) * 1980-05-12 1984-03-16 Rohm & Haas 4-oxo-2-phenyl-nicotinic acids salts and esters and growth regulating compositions
US4714492A (en) * 1980-05-12 1987-12-22 Rohm And Haas Company Certain 2-phenyl-4-oxo-nicotinates and their use for inducing male sterility in a cereal grain plant
US4964896A (en) * 1980-05-12 1990-10-23 Monsanto Company Certain-2,6-diphenyl-1,4-dihydro-4-oxo-nicotinates which are useful for inducing male sterility in cereal grain plants
US4936904A (en) * 1980-05-12 1990-06-26 Carlson Glenn R Aryl-4-oxonicotinates useful for inducing male sterility in cereal grain plants
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3338846A1 (de) * 1982-10-29 1984-05-03 Toyama Chemical Co. Ltd., Tokyo Neue 4-oxo-1,4-dihydronicotinsaeurederivate und salze derselben, verfahren zu ihrer herstellung und antibakterielle mittel mit einem gehalt derselben
JPS5980665A (ja) * 1982-10-29 1984-05-10 Toyama Chem Co Ltd ４−オキソ−１，４−ジヒドロニコチン酸誘導体
GB8502424D0 (en) * 1985-01-31 1985-03-06 Pharis R P Promotion of flowering fruit trees
GB9317314D0 (en) * 1993-08-20 1993-10-06 Smithkline Beecham Corp Compounds
EP2149547A1 (en) * 2008-07-30 2010-02-03 LEK Pharmaceuticals D.D. Process for the synthesis of ezetimibe and intermediates useful therefor
JP6422164B2 (ja) 2013-12-26 2018-11-14 塩野義製薬株式会社 含窒素６員環誘導体およびそれらを含有する医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907808A (en) * 1971-05-17 1975-09-23 Sterling Drug Inc 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives
IN142614B (enExample) * 1974-08-28 1977-08-06 Lilly Co Eli
CA1125762A (en) * 1979-07-13 1982-06-15 Alexander E. Wick Dihydronicotinic acid derivatives and process for the preparation thereof
DE3338846A1 (de) * 1982-10-29 1984-05-03 Toyama Chemical Co. Ltd., Tokyo Neue 4-oxo-1,4-dihydronicotinsaeurederivate und salze derselben, verfahren zu ihrer herstellung und antibakterielle mittel mit einem gehalt derselben

Also Published As

Publication number Publication date
EP0003144A2 (de) 1979-07-25
DE2901868A1 (de) 1979-07-19
JPS54100382A (en) 1979-08-08
GB2013190A (en) 1979-08-08
AU521148B2 (en) 1982-03-18
PT69093A (en) 1979-02-01
ES476917A1 (es) 1979-11-16
GR73088B (enExample) 1984-02-01
US4521535A (en) 1985-06-04
KR820002111B1 (ko) 1982-11-10
EP0003144A3 (en) 1979-08-08
AT369731B (de) 1983-01-25
FI790103A7 (fi) 1979-07-19
DK20279A (da) 1979-07-19
NZ189379A (en) 1984-07-06
GB2013190B (en) 1982-07-14
HU179487B (en) 1982-10-28
SE7900318L (sv) 1979-07-19
NL7900264A (nl) 1979-07-20
IL56421A0 (en) 1979-03-12
FR2415103A1 (fr) 1979-08-17
AU4329679A (en) 1979-07-26
ATA35079A (de) 1982-06-15
IL56421A (en) 1982-08-31
NO790165L (no) 1979-07-19
MC1239A1 (fr) 1979-10-26
EP0003144B1 (de) 1981-08-05
LU80794A1 (de) 1980-02-14
AR223663A1 (es) 1981-09-15
IE47784B1 (en) 1984-06-13
NO152089C (no) 1985-08-14
FR2415103B1 (enExample) 1982-11-05
IE790113L (en) 1979-07-18
NO152089B (no) 1985-04-22
US4549022A (en) 1985-10-22

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