CA1107744A - Imidazolidine derivatives - Google Patents

Imidazolidine derivatives

Info

Publication number
CA1107744A
CA1107744A CA313,826A CA313826A CA1107744A CA 1107744 A CA1107744 A CA 1107744A CA 313826 A CA313826 A CA 313826A CA 1107744 A CA1107744 A CA 1107744A
Authority
CA
Canada
Prior art keywords
formula
manufacture
phenyl
dimethyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA313,826A
Other languages
English (en)
French (fr)
Inventor
Karl Bernauer
Helmut Link
Harro Stohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH546578A external-priority patent/CH642944A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1107744A publication Critical patent/CA1107744A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA313,826A 1977-10-28 1978-10-20 Imidazolidine derivatives Expired CA1107744A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
LU78407 1977-10-28
LU78407 1977-10-28
CH5465/78 1978-05-19
CH546578A CH642944A5 (en) 1978-05-19 1978-05-19 Urea derivatives
CH936778 1978-09-06
CH9367/78 1978-09-06

Publications (1)

Publication Number Publication Date
CA1107744A true CA1107744A (en) 1981-08-25

Family

ID=27175218

Family Applications (1)

Application Number Title Priority Date Filing Date
CA313,826A Expired CA1107744A (en) 1977-10-28 1978-10-20 Imidazolidine derivatives

Country Status (26)

Country Link
US (2) US4407814A (enExample)
EP (1) EP0001813B1 (enExample)
JP (1) JPS5470271A (enExample)
AR (2) AR219560A1 (enExample)
AT (2) AT366374B (enExample)
AU (1) AU522536B2 (enExample)
BR (1) BR7807097A (enExample)
CA (1) CA1107744A (enExample)
CU (1) CU34980A (enExample)
DE (2) DE2861289D1 (enExample)
DK (1) DK481678A (enExample)
ES (3) ES474592A1 (enExample)
FI (1) FI68618C (enExample)
FR (1) FR2422643A1 (enExample)
GB (1) GB2008102B (enExample)
GR (1) GR70681B (enExample)
IE (1) IE47962B1 (enExample)
IL (1) IL55773A (enExample)
IT (1) IT1099450B (enExample)
MC (1) MC1220A1 (enExample)
NL (1) NL7810563A (enExample)
NO (1) NO151461C (enExample)
NZ (1) NZ188721A (enExample)
PH (1) PH13569A (enExample)
PT (1) PT68705A (enExample)
SE (1) SE7811194L (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI801184A7 (fi) * 1979-04-24 1981-01-01 F Hoffmann La Roche & Co Menetelmä imidatsolidiini-johdannaisten valmistamiseksi.
DE2933917A1 (de) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-imino-imidazolidin-2-one und diese enthaltende herbizide.
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US5112983A (en) * 1987-09-28 1992-05-12 Olin Corporation Process for producing 1,2,4-triazol-5-one using organic sulfonic acids and polymers thereof as a catalyst
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
US6492553B1 (en) * 1998-01-29 2002-12-10 Aventis Pharamaceuticals Inc. Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
PL206962B1 (pl) 2001-12-19 2010-10-29 Bristol Myers Squibb Co Związek heterocykliczny o budowie skondensowanej
JP2007514442A (ja) * 2003-12-19 2007-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 前立腺癌治療を評価するための方法および物質
US7718684B2 (en) * 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
DK2656842T3 (en) * 2006-03-27 2016-11-07 Univ California Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES
KR101519705B1 (ko) 2006-03-29 2015-05-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 디아릴티오히단토인 화합물
CL2008003158A1 (es) 2007-10-26 2009-05-29 Univ California Compuestos derivados de diariltiohidantoina con actividad antagonista fuerte y con actividad agonista minima sobre el receptor de androgeno (ar); procedimiento de preparacion; composicion farmaceutica que los comprende; uso en el tratamiento de un desorden proliferativo tal como cancer de prostata.
CA2787083C (en) 2010-02-16 2018-05-22 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
UA117663C2 (uk) 2012-09-26 2018-09-10 Арагон Фармасьютікалз, Інк. Антиандроген для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
BR112020007439A2 (pt) 2017-10-16 2020-10-27 Aragon Pharmaceuticals, Inc. antiandrogênios para o tratamento de câncer de próstata resistente à castração não metastática

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629779A (enExample) *
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
FR1405725A (fr) * 1963-08-23 1965-07-09 Shell Int Research Procédé de préparation de la 5, 5-diméthyl-4-iminohydantoine
NL6904420A (enExample) * 1968-03-28 1969-09-30
US3690863A (en) * 1968-04-19 1972-09-12 Du Pont Esters of 3-(carboxyamino)-and 3-(thiocarboxyamino)-2-substituted crotonamides andtheir use as herbicides
DK123717B (da) * 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS4916937B1 (enExample) * 1970-01-21 1974-04-25
US3676456A (en) * 1970-02-27 1972-07-11 Ciba Geigy Corp Derivatives of 3-aryl-5-alkylhydantoins
JPS5136332B1 (enExample) * 1970-12-09 1976-10-07
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
JPS5315373A (en) * 1976-07-29 1978-02-13 Mitsubishi Chem Ind Ltd Hydantoin derivatives and fungicides containing same for agriculture and horiticulture
IL55774A (en) * 1977-10-28 1982-04-30 Sparamedica Ag Pharmaceutical compositions containing urea derivatives,certain such novel derivatives and their manufacture
US4358606A (en) * 1981-06-19 1982-11-09 Zoecon Corporation Esters of phenalkyloxycarbonylamino acids

Also Published As

Publication number Publication date
AR220004A1 (es) 1980-09-30
ES480109A1 (es) 1980-04-01
EP0001813B1 (de) 1981-11-04
ES480114A1 (es) 1980-04-01
BR7807097A (pt) 1979-05-08
ATA768978A (de) 1981-08-15
NO783642L (no) 1979-05-02
DE2846946A1 (de) 1979-05-03
IL55773A (en) 1982-02-28
AU522536B2 (en) 1982-06-10
ATA18281A (de) 1981-09-15
JPS5470271A (en) 1979-06-05
IE47962B1 (en) 1984-08-08
PH13569A (en) 1980-06-26
GR70681B (enExample) 1982-12-20
NO151461B (no) 1985-01-02
DK481678A (da) 1979-04-29
NO151461C (no) 1985-04-17
IE782130L (en) 1979-04-28
NZ188721A (en) 1984-11-09
FI783170A7 (fi) 1979-04-29
AT366671B (de) 1982-04-26
MC1220A1 (fr) 1979-07-20
DE2861289D1 (en) 1982-01-14
US4482739A (en) 1984-11-13
US4407814A (en) 1983-10-04
SE7811194L (sv) 1979-04-29
FI68618C (fi) 1985-10-10
GB2008102A (en) 1979-05-31
IT1099450B (it) 1985-09-18
CU34980A (es) 1981-12-04
JPS625145B2 (enExample) 1987-02-03
PT68705A (en) 1978-11-01
IL55773A0 (en) 1978-12-17
GB2008102B (en) 1982-07-07
FR2422643B1 (enExample) 1982-10-29
FI68618B (fi) 1985-06-28
AT366374B (de) 1982-04-13
IT7829040A0 (it) 1978-10-24
AU4096178A (en) 1980-05-01
FR2422643A1 (fr) 1979-11-09
ES474592A1 (es) 1980-04-01
NL7810563A (nl) 1979-05-02
EP0001813A1 (de) 1979-05-16
AR219560A1 (es) 1980-08-29

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