CA1106285A - Process for obtaining a natural polar fraction having anti-psoriatic activity - Google Patents
Process for obtaining a natural polar fraction having anti-psoriatic activityInfo
- Publication number
- CA1106285A CA1106285A CA324,314A CA324314A CA1106285A CA 1106285 A CA1106285 A CA 1106285A CA 324314 A CA324314 A CA 324314A CA 1106285 A CA1106285 A CA 1106285A
- Authority
- CA
- Canada
- Prior art keywords
- polypodium
- rhyzomes
- polar fraction
- solution
- evaporated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002682 anti-psoriatic effect Effects 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title claims description 7
- 230000008569 process Effects 0.000 title claims 3
- 238000000605 extraction Methods 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 241000244324 Polypodium aureum Species 0.000 claims description 2
- 241000592274 Polypodium vulgare Species 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 241000723185 Cyathea Species 0.000 claims 1
- 241000393483 Dryopteris crassirhizoma Species 0.000 claims 1
- 241001518143 Polypodium <fern> Species 0.000 claims 1
- 241001362840 Serpocaulon triseriale Species 0.000 claims 1
- 229940075984 polypodium leucotomos Drugs 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 239000003643 water by type Substances 0.000 claims 1
- 241000985694 Polypodiopsida Species 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000003814 drug Substances 0.000 description 9
- 201000004681 Psoriasis Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 239000006193 liquid solution Substances 0.000 description 3
- 239000006194 liquid suspension Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001185 psoriatic effect Effects 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241001310793 Podium Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013681 dietary sucrose Nutrition 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 206010033898 parapsoriasis Diseases 0.000 description 2
- 230000008807 pathological lesion Effects 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241001061225 Arcos Species 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
- 240000001879 Digitalis lutea Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241001624848 Phlebodium Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000000059 bradycardiac effect Effects 0.000 description 1
- 230000002347 carcinogenetic effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229960001701 chloroform Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000727 fraction Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940074045 glyceryl distearate Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229940124562 hematologic agent Drugs 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000002345 steroid group Chemical group 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 238000005353 urine analysis Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES471572A ES471572A1 (es) | 1978-07-07 | 1978-07-07 | Procedimiento de obtencion de fraccion polar natural con ac-tividad antipsoriatica |
| ES471.572 | 1978-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1106285A true CA1106285A (en) | 1981-08-04 |
Family
ID=8476458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA324,314A Expired CA1106285A (en) | 1978-07-07 | 1979-03-28 | Process for obtaining a natural polar fraction having anti-psoriatic activity |
Country Status (35)
| Country | Link |
|---|---|
| JP (1) | JPS6026376B2 (cs) |
| AR (1) | AR230188A1 (cs) |
| AT (1) | AT371715B (cs) |
| AU (1) | AU4876479A (cs) |
| BE (1) | BE874483A (cs) |
| CA (1) | CA1106285A (cs) |
| CH (1) | CH642085A5 (cs) |
| CS (1) | CS215008B2 (cs) |
| DD (1) | DD144719A5 (cs) |
| DE (1) | DE2900887A1 (cs) |
| DK (1) | DK180379A (cs) |
| EG (1) | EG14496A (cs) |
| ES (1) | ES471572A1 (cs) |
| FI (1) | FI792128A7 (cs) |
| FR (1) | FR2434819A1 (cs) |
| GB (1) | GB2024622B (cs) |
| GR (1) | GR65334B (cs) |
| HU (1) | HU179689B (cs) |
| IE (1) | IE48526B1 (cs) |
| IL (1) | IL57721A (cs) |
| IS (1) | IS2495A7 (cs) |
| IT (1) | IT7919807A0 (cs) |
| LU (1) | LU81464A1 (cs) |
| MA (1) | MA18512A1 (cs) |
| MX (1) | MX5596E (cs) |
| NL (1) | NL7905251A (cs) |
| NO (1) | NO792260L (cs) |
| NZ (1) | NZ190933A (cs) |
| OA (1) | OA06288A (cs) |
| PH (1) | PH14338A (cs) |
| PL (1) | PL124244B1 (cs) |
| PT (1) | PT69067A (cs) |
| RO (1) | RO76833A (cs) |
| SE (1) | SE7903762L (cs) |
| ZA (1) | ZA793398B (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES470204A1 (es) * | 1978-05-24 | 1979-01-01 | Conrad Ltd | Procedimiento de obtencion de terpenos naturales con activi-dad antipsoriatica |
| ES8104315A1 (es) * | 1980-04-02 | 1981-04-16 | Conrad Ltd | Un procedimiento de obtencion de un extracto de las fraccio-nes polares de los helechos de la familia polypodiaceae. |
| NO150880C (no) * | 1981-06-01 | 1985-01-16 | Borregaard Ind | Nye aza-krone-etere og anvendelse derav |
| MC2056A1 (fr) * | 1987-12-23 | 1990-09-04 | Psoricur Ltd | Composition therapeutique contre le psoriasis,procede pour sa preparation et utilisation de plantes medicinales qu'elle contient |
| EP0503208A1 (en) * | 1991-03-08 | 1992-09-16 | Maracuyama International, S.A. | Procedure for obtaining a natural water-soluble extract from the leaves and/or rhizomes of various immunologically active ferns |
| JPH0633820U (ja) * | 1992-10-13 | 1994-05-06 | マルヤス機械株式会社 | ローラコンベア |
| ES2068163B1 (es) * | 1994-05-06 | 1995-09-01 | Esp Farmaceuticas Centrum Sa | Procedimiento de obtencion de un extracto vegetal con actividad en el tratamiento de disfunciones cognitivas y/o neuroinmunes. |
| EP0680762B1 (en) * | 1994-05-06 | 2002-08-14 | Especialidades Farmaceuticas Centrum, S.A. | Pharmaceutical composition comprising fern extract(s) for the treatment of neurodegenerative diseases. |
| ES2137900B1 (es) * | 1998-06-02 | 2000-08-16 | Helsint S A L | Empleo de formulaciones a base de una fraccion hidrosoluble de phlebodium decumanum como complemento nutricional en el tratamiento del sindrome caquectico en pacientes oncologicos. |
| EP1040834A1 (en) * | 1997-07-30 | 2000-10-04 | Helsint S.A.L. | HYDROSOLUBLE FRACTIONS OF $i(PHLEBODIUM DECUMANUM) AND USE THEREOF AS NUTRITIONAL COMPLEMENTS IN AIDS AND CANCER PATIENTS |
| ES2124675B1 (es) * | 1997-07-30 | 1999-10-01 | Helsint S A L | "formulaciones a base de una fraccion hidrosoluble de phlebodium decumanum, y su uso en el tratamiento del sindrome caquectico en enfermos de sida". |
| FR2863163B1 (fr) * | 2003-12-04 | 2006-02-24 | Oreal | Composition, notamment cosmetique, comprenant des extraits de fougere et de nacre |
| FR2876032B1 (fr) * | 2004-10-05 | 2008-10-31 | Greentech Sa Sa | Utilisation d'extraits de fougeres dans des preparations cosmetiques ou dermatologiques |
| US20060246115A1 (en) * | 2005-03-04 | 2006-11-02 | Ricardo Rueda | Nutritional products for ameliorating symptoms of rheumatoid arthritis |
| USD554789S1 (en) * | 2006-09-14 | 2007-11-06 | Huo-Tu Huang | Table lamp |
| AT515350A1 (de) * | 2014-02-10 | 2015-08-15 | Christoph Dipl Ing Brandstätter | Verfahren zur Herstellung eines Konzentrats eines Holzschutzmittels, damit hergestelltes Konzentrat und Verfahren zur Behandlung von Holz |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB256768A (en) * | 1925-07-17 | 1926-08-19 | Francesco Fumarola | Process for extraction of the active biological principles from the ether extract of male fern |
| US3395223A (en) * | 1965-05-13 | 1968-07-30 | Carter Wallace | Fern extract for treating gastric ulcers |
| FR2395266A1 (fr) * | 1977-06-23 | 1979-01-19 | Suffren Ste Parti Brevets | -lactone monomeres et leurs polymeres, sels et derives, utilisables notamment comme colorants, adjuvants de tannage et medicaments |
| JPS5464870A (en) * | 1977-10-21 | 1979-05-25 | Gte Laboratories Inc | Solid state microwave power supply for electrodeless light source |
-
1978
- 1978-07-07 ES ES471572A patent/ES471572A1/es not_active Expired
- 1978-12-27 AR AR274971A patent/AR230188A1/es active
- 1978-12-28 GR GR57991A patent/GR65334B/el unknown
-
1979
- 1979-01-11 DE DE19792900887 patent/DE2900887A1/de not_active Withdrawn
- 1979-01-12 PT PT69067A patent/PT69067A/pt unknown
- 1979-01-29 FR FR7902226A patent/FR2434819A1/fr active Granted
- 1979-02-01 IT IT7919807A patent/IT7919807A0/it unknown
- 1979-02-27 BE BE193723A patent/BE874483A/xx not_active IP Right Cessation
- 1979-03-28 CA CA324,314A patent/CA1106285A/en not_active Expired
- 1979-04-27 SE SE7903762A patent/SE7903762L/xx unknown
- 1979-05-02 DK DK180379A patent/DK180379A/da not_active Application Discontinuation
- 1979-05-22 CH CH477779A patent/CH642085A5/de not_active IP Right Cessation
- 1979-05-24 JP JP54064871A patent/JPS6026376B2/ja not_active Expired
- 1979-05-24 GB GB7918174A patent/GB2024622B/en not_active Expired
- 1979-05-29 MX MX798029U patent/MX5596E/es unknown
- 1979-07-04 IL IL57721A patent/IL57721A/xx unknown
- 1979-07-05 NL NL7905251A patent/NL7905251A/nl not_active Application Discontinuation
- 1979-07-05 LU LU81464A patent/LU81464A1/fr unknown
- 1979-07-05 FI FI792128A patent/FI792128A7/fi not_active Application Discontinuation
- 1979-07-05 IS IS2495A patent/IS2495A7/is unknown
- 1979-07-06 HU HU79CO371A patent/HU179689B/hu unknown
- 1979-07-06 PL PL1979216905A patent/PL124244B1/pl unknown
- 1979-07-06 NO NO792260A patent/NO792260L/no unknown
- 1979-07-06 OA OA56841A patent/OA06288A/xx unknown
- 1979-07-06 AT AT0471479A patent/AT371715B/de not_active IP Right Cessation
- 1979-07-06 CS CS794777A patent/CS215008B2/cs unknown
- 1979-07-06 MA MA18709A patent/MA18512A1/fr unknown
- 1979-07-06 NZ NZ190933A patent/NZ190933A/xx unknown
- 1979-07-06 ZA ZA793398A patent/ZA793398B/xx unknown
- 1979-07-07 RO RO7998089A patent/RO76833A/ro unknown
- 1979-07-07 EG EG415/79A patent/EG14496A/xx active
- 1979-07-09 PH PH22755A patent/PH14338A/en unknown
- 1979-07-09 DD DD79214207A patent/DD144719A5/de unknown
- 1979-07-09 AU AU48764/79A patent/AU4876479A/en not_active Abandoned
- 1979-08-08 IE IE1274/79A patent/IE48526B1/en unknown
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