CA1105942A - Preparation of therapeutic agents - Google Patents

Preparation of therapeutic agents

Info

Publication number
CA1105942A
CA1105942A CA298,426A CA298426A CA1105942A CA 1105942 A CA1105942 A CA 1105942A CA 298426 A CA298426 A CA 298426A CA 1105942 A CA1105942 A CA 1105942A
Authority
CA
Canada
Prior art keywords
process according
acid
salt
alpha
ethylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA298,426A
Other languages
English (en)
French (fr)
Inventor
James G. Tantum
John S. Nicholson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9697/77A external-priority patent/GB1596032A/en
Application filed by Boots Co PLC filed Critical Boots Co PLC
Application granted granted Critical
Publication of CA1105942A publication Critical patent/CA1105942A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA298,426A 1977-03-08 1978-03-07 Preparation of therapeutic agents Expired CA1105942A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9697/77 1977-03-08
GB9697/77A GB1596032A (en) 1977-03-08 1977-03-08 Resolution of optically active 2-arylpropionic acids
GB194678 1978-01-18
GB1946/78 1978-01-18

Publications (1)

Publication Number Publication Date
CA1105942A true CA1105942A (en) 1981-07-28

Family

ID=26237091

Family Applications (1)

Application Number Title Priority Date Filing Date
CA298,426A Expired CA1105942A (en) 1977-03-08 1978-03-07 Preparation of therapeutic agents

Country Status (29)

Country Link
JP (1) JPS53112841A (nl)
AT (1) AT360508B (nl)
AU (1) AU521708B2 (nl)
BG (1) BG28567A3 (nl)
CA (1) CA1105942A (nl)
CH (1) CH638482A5 (nl)
CS (1) CS222255B2 (nl)
DD (1) DD136261A5 (nl)
DE (1) DE2809794A1 (nl)
DK (1) DK154418C (nl)
EG (1) EG13345A (nl)
ES (1) ES467606A1 (nl)
FI (1) FI66828C (nl)
FR (1) FR2383155A1 (nl)
GR (1) GR64816B (nl)
HU (1) HU178810B (nl)
IE (1) IE46476B1 (nl)
IN (1) IN147834B (nl)
IT (1) IT1202818B (nl)
LU (1) LU79186A1 (nl)
NL (1) NL189126C (nl)
NO (1) NO146197C (nl)
NZ (1) NZ186644A (nl)
PH (1) PH13333A (nl)
PL (1) PL110888B1 (nl)
PT (1) PT67743A (nl)
SE (1) SE436422B (nl)
SU (1) SU784759A3 (nl)
YU (1) YU41472B (nl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2826952A1 (de) * 1978-06-20 1980-01-10 Bayer Ag Enantiomerentrennung von chiralen carbonsaeuren
PH15674A (en) * 1979-07-06 1983-03-11 Syntex Corp Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
JPS57145830A (en) * 1981-03-06 1982-09-09 Hiroyuki Nohira Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid
JPH01126425U (nl) * 1988-02-23 1989-08-29
DE3824353A1 (de) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
DE4319438C1 (de) * 1993-06-11 1994-06-01 Gerd Dr Dr Geislinger Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren
JP3782834B2 (ja) 1994-10-26 2006-06-07 株式会社トクホン 鎮痛抗炎症貼付剤
DE19717429A1 (de) 1997-04-25 1998-12-24 Bayer Ag Herstellung enantiomerenreiner Biarylketocarbonsäuren
US20120029226A1 (en) 2009-02-06 2012-02-02 Bernardus Kaptein Method for the synthesis of chiral alpha-aryl propionic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23268A (en) * 1964-05-07 1969-02-27 Merck & Co Inc Anti-inflammatory preparations containing the 4-phenyl-alpha-methyl acid acetic phenyl acid
FR2015728A1 (en) * 1968-04-18 1970-04-30 Lilly Co Eli Anti-inflammatory substd-phenylalkanoic acids and - derivs
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids

Also Published As

Publication number Publication date
NO146197C (no) 1982-08-18
FI66828B (fi) 1984-08-31
IE780467L (en) 1978-09-08
DE2809794A1 (de) 1978-09-21
DE2809794C2 (nl) 1989-08-03
DK154418B (da) 1988-11-14
YU54078A (en) 1984-04-30
DK100878A (da) 1978-09-09
JPS626536B2 (nl) 1987-02-12
NL7802520A (nl) 1978-09-12
ES467606A1 (es) 1978-10-16
AT360508B (de) 1981-01-12
NZ186644A (en) 1980-10-24
PH13333A (en) 1980-03-13
CH638482A5 (en) 1983-09-30
EG13345A (en) 1981-06-30
SE7802603L (sv) 1978-09-09
AU3397778A (en) 1979-09-13
FI780738A (fi) 1978-09-09
IT1202818B (it) 1989-02-09
PL110888B1 (en) 1980-08-30
IT7848320A0 (it) 1978-03-07
FI66828C (fi) 1984-12-10
IN147834B (nl) 1980-07-19
NO780785L (no) 1978-09-11
BG28567A3 (bg) 1980-05-15
GR64816B (en) 1980-06-03
YU41472B (en) 1987-08-31
CS222255B2 (en) 1983-06-24
DK154418C (da) 1989-06-19
IE46476B1 (en) 1983-06-29
NL189126C (nl) 1993-01-18
SU784759A3 (ru) 1980-11-30
SE436422B (sv) 1984-12-10
ATA163478A (de) 1980-06-15
LU79186A1 (fr) 1978-09-18
PT67743A (en) 1978-04-01
NO146197B (no) 1982-05-10
NL189126B (nl) 1992-08-17
DD136261A5 (de) 1979-06-27
JPS53112841A (en) 1978-10-02
FR2383155B1 (nl) 1983-12-30
FR2383155A1 (fr) 1978-10-06
PL205161A1 (pl) 1979-03-26
AU521708B2 (en) 1982-04-29
HU178810B (en) 1982-06-28

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