CA1105463A - Dihydropyridine-derivatives and their production - Google Patents
Dihydropyridine-derivatives and their productionInfo
- Publication number
- CA1105463A CA1105463A CA305,727A CA305727A CA1105463A CA 1105463 A CA1105463 A CA 1105463A CA 305727 A CA305727 A CA 305727A CA 1105463 A CA1105463 A CA 1105463A
- Authority
- CA
- Canada
- Prior art keywords
- carbon atoms
- alkyl
- formula
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH7520/77 | 1977-06-20 | ||
CH752077 | 1977-06-20 | ||
CH2865/78 | 1978-03-16 | ||
CH286578 | 1978-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1105463A true CA1105463A (en) | 1981-07-21 |
Family
ID=25691589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA305,727A Expired CA1105463A (en) | 1977-06-20 | 1978-06-19 | Dihydropyridine-derivatives and their production |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0000150B1 (da) |
JP (1) | JPS54103876A (da) |
AT (1) | AT376220B (da) |
AU (1) | AU524000B2 (da) |
CA (1) | CA1105463A (da) |
CY (1) | CY1239A (da) |
DE (1) | DE2860708D1 (da) |
DK (1) | DK149855C (da) |
ES (1) | ES470917A1 (da) |
FI (1) | FI64938C (da) |
HK (1) | HK65184A (da) |
IE (1) | IE47212B1 (da) |
IL (1) | IL54948A (da) |
IT (1) | IT1105364B (da) |
LU (1) | LU88342I2 (da) |
MY (1) | MY8500041A (da) |
NL (1) | NL930126I2 (da) |
NZ (1) | NZ187617A (da) |
PT (1) | PT68191A (da) |
SG (1) | SG20584G (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH639659A5 (de) * | 1978-12-18 | 1983-11-30 | Sandoz Ag | Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung. |
DK525179A (da) * | 1978-12-18 | 1980-06-19 | Sandoz Ag | Fremgangsmaade til fremstilling af benzoxadiazoler og benzothiazoler |
BE886259A (fr) * | 1979-11-23 | 1981-05-20 | Sandoz Sa | Nouveaux medicament a base de derives de la 1,4-dihydropyridine, pour le traitement de l'insuffisance cerebrovasculaire ou a action spamolytique |
CH655658B (da) * | 1980-09-18 | 1986-05-15 | ||
FI813460L (fi) * | 1980-11-10 | 1982-05-11 | Sandoz Ag | Nya 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-pyridinderivat deras framstaellningsfoerfarande och dessa innehaollande farmaceutiska kompositioner |
EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
DE3208628A1 (de) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
FR2528431B1 (fr) * | 1982-06-15 | 1986-01-10 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments |
FR2554109A1 (fr) * | 1983-11-01 | 1985-05-03 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments |
IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
NL194389C (nl) * | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
GB8428552D0 (en) * | 1984-11-12 | 1984-12-19 | Sandoz Ltd | Organic compounds |
US5260321A (en) * | 1984-11-12 | 1993-11-09 | Sandoz Ltd. | Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
GB8616047D0 (en) * | 1986-07-01 | 1986-08-06 | Sandoz Ltd | A 1 4-dihydropyridine derivatives |
CN1649614A (zh) | 2002-02-22 | 2005-08-03 | 新河药品股份有限公司 | 活性剂传递系统和保护及施用活性剂的方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
-
1978
- 1978-06-12 FI FI781867A patent/FI64938C/fi not_active IP Right Cessation
- 1978-06-12 DK DK262578A patent/DK149855C/da not_active IP Right Cessation
- 1978-06-15 CY CY1239A patent/CY1239A/xx unknown
- 1978-06-15 DE DE7878100165T patent/DE2860708D1/de not_active Expired
- 1978-06-15 EP EP78100165A patent/EP0000150B1/en not_active Expired
- 1978-06-19 JP JP7332778A patent/JPS54103876A/ja active Granted
- 1978-06-19 PT PT68191A patent/PT68191A/pt unknown
- 1978-06-19 NZ NZ187617A patent/NZ187617A/xx unknown
- 1978-06-19 IE IE1231/78A patent/IE47212B1/en not_active IP Right Cessation
- 1978-06-19 IT IT49939/78A patent/IT1105364B/it active Protection Beyond IP Right Term
- 1978-06-19 ES ES470917A patent/ES470917A1/es not_active Expired
- 1978-06-19 IL IL54948A patent/IL54948A/xx unknown
- 1978-06-19 AU AU37252/78A patent/AU524000B2/en not_active Expired
- 1978-06-19 CA CA305,727A patent/CA1105463A/en not_active Expired
- 1978-06-19 AT AT0443178A patent/AT376220B/de not_active IP Right Cessation
-
1984
- 1984-03-05 SG SG205/84A patent/SG20584G/en unknown
- 1984-08-23 HK HK651/84A patent/HK65184A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY41/85A patent/MY8500041A/xx unknown
-
1993
- 1993-06-30 LU LU88342C patent/LU88342I2/fr unknown
- 1993-07-01 NL NL930126C patent/NL930126I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DK149855C (da) | 1987-04-21 |
NL930126I1 (nl) | 1993-11-01 |
JPS6360755B2 (da) | 1988-11-25 |
ATA443178A (de) | 1984-03-15 |
DK262578A (da) | 1978-12-21 |
IE47212B1 (en) | 1984-01-25 |
IT1105364B (it) | 1985-10-28 |
IT7849939A0 (it) | 1978-06-19 |
IL54948A (en) | 1982-01-31 |
AU3725278A (en) | 1980-01-03 |
PT68191A (fr) | 1978-07-01 |
MY8500041A (en) | 1985-12-31 |
FI64938B (fi) | 1983-10-31 |
FI781867A (fi) | 1978-12-21 |
CY1239A (en) | 1984-06-29 |
DE2860708D1 (en) | 1981-08-27 |
LU88342I2 (fr) | 1994-05-04 |
NZ187617A (en) | 1980-12-19 |
ES470917A1 (es) | 1979-10-01 |
SG20584G (en) | 1985-03-08 |
DK149855B (da) | 1986-10-13 |
IL54948A0 (en) | 1978-08-31 |
AT376220B (de) | 1984-10-25 |
FI64938C (fi) | 1984-02-10 |
HK65184A (en) | 1984-08-31 |
AU524000B2 (en) | 1982-08-26 |
IE781231L (en) | 1978-12-20 |
EP0000150B1 (en) | 1981-05-20 |
EP0000150A1 (en) | 1979-01-10 |
NL930126I2 (nl) | 1995-02-16 |
JPS54103876A (en) | 1979-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1105463A (en) | Dihydropyridine-derivatives and their production | |
EP0094159B1 (en) | Dihydropyridine derivatives, their production and use | |
US4782061A (en) | Method of treating psychotropic conditions employing substituted piperazine compounds | |
US4552874A (en) | Pyrazolooxazines, pyrazolothiazines, and pryazoloquinolines and their use as medicaments | |
US4466972A (en) | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them | |
US3980658A (en) | (Indolyl-piperidino or -1,2,5,6-tetrahydro-pyridyl)-p-fluoro-butyrophenones and salts thereof | |
DE3686248D1 (de) | Piperidinderivat, seine verwendung und diese enthaltende pharmazeutische zusammensetzung. | |
WO1997017329A1 (fr) | Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant | |
JPS59176282A (ja) | 薬理活性を有する化合物の異性体、その製法及びそれを含む製薬組成物 | |
GB2103203A (en) | 1,4-dihydropyridines, their preparation and pharmaceutical compositions containing them | |
ATE9464T1 (de) | Neue carbonsaeureamide, ihre herstellung und ihre verwendung als arzneimittel. | |
ES8106891A1 (es) | Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas | |
EP0010130B1 (de) | Sila-substituierte 1,4-Dihydropyridinderivate, Verfahren zu ihrer Herstellung, Arzneimittel und Verfahren zu deren Herstellung | |
CA1131228A (en) | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them | |
US4086349A (en) | Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma | |
DE3130041A1 (de) | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung | |
KR870002069A (ko) | 2-(3,5-디알킬-4-히드록시페닐) 인돌 유도체의 제조방법 | |
EP0027895A1 (en) | 1-(2-(Alkyl and arylsulfonyl)-2-propenyl and propyl) substituted piperidines and pharmaceutical and antimicrobial compositions comprising the same | |
Morel et al. | 2-aza-1, 3-dienes with electron-releasing substituents at the 1, 3 positions. Reagents for the construction of pyridine and pyrimidine derivatives | |
ES471593A1 (es) | Procedimiento para preparar nuevos derivados indolicos | |
US4567271A (en) | Benzoxadiazoles and benzothiadiazoles | |
US4647568A (en) | Circulation-active hydroxy-tetra-hydropyridinelactones | |
GB1443609A (en) | Indazole-3-carboxylic acid hydrazides and a process for the preparation thereof | |
US3880850A (en) | Pyrimido(4,5-d)pyridazine derivatives and process for producing them | |
US3946075A (en) | 2-Aminomethylene-1-phenyl-1,3-butanedione |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |