CA1105034A - Benzimidazole derivatives - Google Patents

Benzimidazole derivatives

Info

Publication number
CA1105034A
CA1105034A CA300,973A CA300973A CA1105034A CA 1105034 A CA1105034 A CA 1105034A CA 300973 A CA300973 A CA 300973A CA 1105034 A CA1105034 A CA 1105034A
Authority
CA
Canada
Prior art keywords
group
carbon atoms
hydrogen
halogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA300,973A
Other languages
English (en)
French (fr)
Inventor
Jean J. Gallay
Manfred Kuhne
Max Schellenbaum
Oswald Rechsteiner
Alfred Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU77120A external-priority patent/LU77120A1/xx
Priority claimed from LU79232A external-priority patent/LU79232A1/de
Application filed by Ciba Geigy Investments Ltd filed Critical Ciba Geigy Investments Ltd
Application granted granted Critical
Publication of CA1105034A publication Critical patent/CA1105034A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA300,973A 1977-04-12 1978-04-12 Benzimidazole derivatives Expired CA1105034A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU77120 1977-04-12
LU77120A LU77120A1 (enExample) 1977-04-12 1977-04-12
LU79232 1978-03-15
LU79232A LU79232A1 (de) 1978-03-15 1978-03-15 Verfahren zur herstellung von anthelmintika

Publications (1)

Publication Number Publication Date
CA1105034A true CA1105034A (en) 1981-07-14

Family

ID=26640224

Family Applications (1)

Application Number Title Priority Date Filing Date
CA300,973A Expired CA1105034A (en) 1977-04-12 1978-04-12 Benzimidazole derivatives

Country Status (27)

Country Link
US (1) US4197307A (enExample)
JP (1) JPS6019753B2 (enExample)
AR (1) AR230270A1 (enExample)
AT (1) AT363078B (enExample)
AU (1) AU520836B2 (enExample)
BE (1) BE865870A (enExample)
CA (1) CA1105034A (enExample)
CH (1) CH634306A5 (enExample)
CS (1) CS209450B2 (enExample)
DE (1) DE2815621A1 (enExample)
DK (1) DK155603C (enExample)
FR (1) FR2387220A1 (enExample)
GB (1) GB1599970A (enExample)
IE (1) IE46718B1 (enExample)
IL (1) IL54474A (enExample)
IT (1) IT1113128B (enExample)
KE (1) KE3345A (enExample)
MX (1) MX5951E (enExample)
MY (1) MY8500089A (enExample)
NL (1) NL187808C (enExample)
NZ (1) NZ186936A (enExample)
PH (1) PH18234A (enExample)
PL (2) PL117396B1 (enExample)
SE (1) SE444315B (enExample)
SU (1) SU1097196A3 (enExample)
YU (1) YU41309B (enExample)
ZA (1) ZA782086B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132167A1 (de) * 1981-08-14 1983-03-03 Hoechst Ag, 6000 Frankfurt "5(6)-phenylsulfonyloxy-benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung gegen leberegel"
MA19678A1 (fr) * 1982-01-13 1983-10-01 Ciba Geigy Ag Agents anti-helmintiques.
GB2124904B (en) * 1982-08-13 1986-01-15 Ciba Geigy Ag Synergistic anthelmintic compositions
US4472419A (en) * 1984-01-25 1984-09-18 American Cyanamid Company Method of controlling plant nematodes
GB8426367D0 (en) * 1984-10-18 1984-11-21 Shell Int Research Heteroaromatic ether herbicides
US4781920A (en) * 1984-11-13 1988-11-01 American Cyanamid Company Anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
DE3508665A1 (de) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt Heterocyclische sulfide und ihre anwendung als immunmodulatoren
GB8519920D0 (en) * 1985-08-08 1985-09-18 Fbc Ltd Fungicides
JPS62246587A (ja) * 1986-03-17 1987-10-27 ピ−ピ−ジ−　インダストリイズ，インコ−ポレイテツド 除草活性を有する置換ベンゾオキサゾロン（またはベンゾチアゾロン）化合物
DE3719783A1 (de) * 1987-06-13 1988-12-22 Hoechst Ag Verfahren zur herstellung von 5-phenylsulfinyl-1h-2-(methoxycarbonylamino)- benzimidazol
AU2003236405B2 (en) * 1999-04-14 2007-10-25 Merial Ltd Anthelmintic Composition
NZ335166A (en) 1999-04-14 2001-11-30 Ashmont Holdings Ltd Anthelmintic composition containing triclabendazole in at least one solvent
US5538989A (en) * 1993-11-10 1996-07-23 Hoechst-Roussel Agri-Vet Company Fenbendazole formulations
US7001889B2 (en) * 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20060205681A1 (en) * 2002-06-21 2006-09-14 Maryam Moaddeb Homogenous paste formulations
US20040224984A1 (en) 2003-03-03 2004-11-11 Selph Jeffrey L. Methods of treating inflammations and infections with pyridinium salts
WO2005074914A1 (en) * 2004-02-03 2005-08-18 Wyeth Anthelmintic composition
TWI387592B (zh) * 2005-08-30 2013-03-01 Novartis Ag 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations
MX2011003720A (es) * 2008-10-08 2011-04-28 Wyeth Llc Composiciones antihelminticas de bencimidazol.
CN101555231B (zh) * 2009-05-04 2011-03-23 扬州天和药业有限公司 一种制备三氯苯达唑的方法
WO2012070068A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited Process for preparation of triclabendazole
EA028430B1 (ru) * 2012-04-20 2017-11-30 Мериал, Инк. Паразитицидные композиции, содержащие производные бензимидазола, их способы получения и применения
CN103319416B (zh) * 2013-06-24 2015-02-25 常州佳灵药业有限公司 新型兽药三氯苯达唑亚砜及其制备方法
EP3235815A1 (de) 2016-04-19 2017-10-25 Philipps-Universität Marburg Wirkstoffe gegen parasitäre helminthen
RU2640482C2 (ru) * 2016-04-22 2018-01-09 ФАНО России Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт фундаментальной и прикладной паразитологии животных и растений им. К.И. Скрябина (ФГБНУ "ВНИИП им. К.И. Скрябина") Супрамолекулярный комплекс триклабендазола для лечения животных при фасциолёзе
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
AR118215A1 (es) 2019-03-01 2021-09-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones inyectables de clorsulón, sus métodos y usos
EP4028008A4 (en) 2019-09-12 2023-09-13 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
AU2022228569A1 (en) * 2021-03-03 2023-10-12 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
KR20250166323A (ko) 2023-04-07 2025-11-27 테른스 파마슈티칼스, 인크. 간 장애 또는 심장대사 질환의 치료에 사용하기 위한 thr베타 효현제 및 glp-1r 효현제를 포함하는 조합

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666764A (en) * 1951-07-14 1954-01-19 Ciba Pharm Prod Inc Process of splitting aralkylheterocyclic thioethers with aluminum bromide
FR1476558A (fr) * 1965-07-26 1967-04-14 Chimetron Sarl Thiazolylthiobenzimidazoles et thiazolylsulfinylbenzimidazoles
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3506767A (en) * 1965-08-06 1970-04-14 Geigy Chem Corp Benzimidazole compositions and methods of use
FR1509192A (fr) * 1966-12-01 1968-01-12 Benzylthio-2 benzimidazoles
US3480643A (en) * 1967-05-09 1969-11-25 American Cyanamid Co Alkylsulfonylbenzimidazoles
NL7013343A (enExample) * 1969-09-26 1971-03-30
BE754874A (fr) * 1969-10-30 1971-01-18 Buckman Labor Inc Composes s-chloromethyliques de 2-mercapto-benzothiazole, de 2-mercaptobenzoxazole et de 2-mercaptobenzimidazole
DE2041324A1 (de) * 1970-08-20 1972-02-24 Agfa Gevaert Ag Neue Benzimidazolderivate,sowie ein Verfahren zu ihrer Herstellung
US3933841A (en) * 1971-05-24 1976-01-20 Ciba-Geigy Corporation 2-Phenoxy, -phenylthio-, and -phenyl-amino-benzoxazoles having an isothiocyano substituent
US3840550A (en) * 1971-05-24 1974-10-08 Ciba Geigy Corp Certain 6-isothiocyanobenzothiazoles
BE792402A (fr) * 1971-12-07 1973-06-07 Ciba Geigy Composes heterocycliques azotes et medicaments anthelminthiqueset antimicrobiens qui en contiennent

Also Published As

Publication number Publication date
NL7803886A (nl) 1978-10-16
DK155603B (da) 1989-04-24
YU85778A (en) 1983-01-21
IT7822189A0 (it) 1978-04-11
CS209450B2 (en) 1981-12-31
YU41309B (en) 1987-02-28
BE865870A (fr) 1978-10-11
DK159478A (da) 1978-10-13
CH634306A5 (de) 1983-01-31
DE2815621A1 (de) 1978-10-19
IL54474A0 (en) 1978-07-31
AR230270A1 (es) 1984-03-01
AU520836B2 (en) 1982-03-04
PH18234A (en) 1985-05-03
JPS6019753B2 (ja) 1985-05-17
ATA253478A (de) 1980-12-15
DK155603C (da) 1989-09-04
FR2387220A1 (fr) 1978-11-10
AT363078B (de) 1981-07-10
KE3345A (en) 1983-12-16
NL187808C (nl) 1992-01-16
MY8500089A (en) 1985-12-31
DE2815621C2 (enExample) 1990-08-09
ZA782086B (en) 1979-03-28
PL117396B1 (en) 1981-07-31
AU3502278A (en) 1979-10-18
SE444315B (sv) 1986-04-07
IE780704L (en) 1978-10-12
JPS53127476A (en) 1978-11-07
MX5951E (es) 1984-09-06
PL206019A1 (pl) 1979-06-04
IE46718B1 (en) 1983-09-07
US4197307A (en) 1980-04-08
SE7804057L (sv) 1978-10-13
FR2387220B1 (enExample) 1983-06-03
NL187808B (nl) 1991-08-16
NZ186936A (en) 1980-10-24
PL115361B1 (en) 1981-03-31
GB1599970A (en) 1981-10-07
IL54474A (en) 1982-04-30
SU1097196A3 (ru) 1984-06-07
IT1113128B (it) 1986-01-20

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Legal Events

Date Code Title Description
MKEX Expiry