CA1098910A - 3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives - Google Patents

3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives

Info

Publication number
CA1098910A
CA1098910A CA327,140A CA327140A CA1098910A CA 1098910 A CA1098910 A CA 1098910A CA 327140 A CA327140 A CA 327140A CA 1098910 A CA1098910 A CA 1098910A
Authority
CA
Canada
Prior art keywords
compound
formula
methyl
amino
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA327,140A
Other languages
English (en)
French (fr)
Inventor
Robert N. Schut
Max E. Safdy
Enrique Hong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Application granted granted Critical
Publication of CA1098910A publication Critical patent/CA1098910A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA327,140A 1978-06-15 1979-05-08 3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives Expired CA1098910A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91573578A 1978-06-15 1978-06-15
US915,735 1978-06-15

Publications (1)

Publication Number Publication Date
CA1098910A true CA1098910A (en) 1981-04-07

Family

ID=25436194

Family Applications (1)

Application Number Title Priority Date Filing Date
CA327,140A Expired CA1098910A (en) 1978-06-15 1979-05-08 3-amino-2-(5-fluoro and 5-methoxy-1h-indol-3-yl) propanoic acid derivatives

Country Status (6)

Country Link
JP (1) JPS6040420B2 (enrdf_load_stackoverflow)
CA (1) CA1098910A (enrdf_load_stackoverflow)
DE (1) DE2921978A1 (enrdf_load_stackoverflow)
FR (1) FR2428630A1 (enrdf_load_stackoverflow)
GB (1) GB2023590B (enrdf_load_stackoverflow)
IL (1) IL57367A0 (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0514111U (ja) * 1991-08-12 1993-02-23 エステー化学株式会社 作業用腕カバー
JPH0519308U (ja) * 1991-08-23 1993-03-09 由美子 松本 日焼防止ブラウス
UA88767C2 (uk) * 2003-07-17 2009-11-25 Плексікон, Інк. Ppar активні сполуки
EP3016950B1 (en) 2013-07-02 2017-06-07 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
AR096788A1 (es) 2013-07-02 2016-02-03 Bristol Myers Squibb Co Compuestos tricíclicos de carboxamida como inhibidores potentes de rock

Also Published As

Publication number Publication date
FR2428630A1 (fr) 1980-01-11
JPS6040420B2 (ja) 1985-09-11
GB2023590A (en) 1980-01-03
FR2428630B1 (enrdf_load_stackoverflow) 1983-04-15
GB2023590B (en) 1982-11-17
DE2921978A1 (de) 1979-12-20
IL57367A0 (en) 1979-09-30
JPS55397A (en) 1980-01-05
DE2921978C2 (enrdf_load_stackoverflow) 1988-09-01

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19980407