GB2023590B - 3 - amino - 2 - 5 fluoro and 5-methoxy-1h-indol - 3 - yl propanoic acid derivatives and their preparation and use - Google Patents

3 - amino - 2 - 5 fluoro and 5-methoxy-1h-indol - 3 - yl propanoic acid derivatives and their preparation and use

Info

Publication number
GB2023590B
GB2023590B GB7919449A GB7919449A GB2023590B GB 2023590 B GB2023590 B GB 2023590B GB 7919449 A GB7919449 A GB 7919449A GB 7919449 A GB7919449 A GB 7919449A GB 2023590 B GB2023590 B GB 2023590B
Authority
GB
United Kingdom
Prior art keywords
indol
fluoro
methoxy
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7919449A
Other languages
English (en)
Other versions
GB2023590A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB2023590A publication Critical patent/GB2023590A/en
Application granted granted Critical
Publication of GB2023590B publication Critical patent/GB2023590B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7919449A 1978-06-15 1979-06-04 3 - amino - 2 - 5 fluoro and 5-methoxy-1h-indol - 3 - yl propanoic acid derivatives and their preparation and use Expired GB2023590B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91573578A 1978-06-15 1978-06-15

Publications (2)

Publication Number Publication Date
GB2023590A GB2023590A (en) 1980-01-03
GB2023590B true GB2023590B (en) 1982-11-17

Family

ID=25436194

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7919449A Expired GB2023590B (en) 1978-06-15 1979-06-04 3 - amino - 2 - 5 fluoro and 5-methoxy-1h-indol - 3 - yl propanoic acid derivatives and their preparation and use

Country Status (6)

Country Link
JP (1) JPS6040420B2 (enrdf_load_stackoverflow)
CA (1) CA1098910A (enrdf_load_stackoverflow)
DE (1) DE2921978A1 (enrdf_load_stackoverflow)
FR (1) FR2428630A1 (enrdf_load_stackoverflow)
GB (1) GB2023590B (enrdf_load_stackoverflow)
IL (1) IL57367A0 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2356889C2 (ru) * 2003-07-17 2009-05-27 Плекссикон, Инк. Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0514111U (ja) * 1991-08-12 1993-02-23 エステー化学株式会社 作業用腕カバー
JPH0519308U (ja) * 1991-08-23 1993-03-09 由美子 松本 日焼防止ブラウス
EP3016950B1 (en) 2013-07-02 2017-06-07 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
AR096788A1 (es) 2013-07-02 2016-02-03 Bristol Myers Squibb Co Compuestos tricíclicos de carboxamida como inhibidores potentes de rock

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2356889C2 (ru) * 2003-07-17 2009-05-27 Плекссикон, Инк. Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом

Also Published As

Publication number Publication date
FR2428630A1 (fr) 1980-01-11
JPS6040420B2 (ja) 1985-09-11
GB2023590A (en) 1980-01-03
CA1098910A (en) 1981-04-07
FR2428630B1 (enrdf_load_stackoverflow) 1983-04-15
DE2921978A1 (de) 1979-12-20
IL57367A0 (en) 1979-09-30
JPS55397A (en) 1980-01-05
DE2921978C2 (enrdf_load_stackoverflow) 1988-09-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19980604