CA1095041A - 0-2-isocephem antibacterial agents and processes and intermediates for their production - Google Patents

0-2-isocephem antibacterial agents and processes and intermediates for their production

Info

Publication number
CA1095041A
CA1095041A CA242,795A CA242795A CA1095041A CA 1095041 A CA1095041 A CA 1095041A CA 242795 A CA242795 A CA 242795A CA 1095041 A CA1095041 A CA 1095041A
Authority
CA
Canada
Prior art keywords
img
alkyl
benzyl
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA242,795A
Other languages
English (en)
French (fr)
Inventor
Bing Y. Luh
Bernard R. Belleau
Terrence W. Doyle
Terry T. Conway
Original Assignee
Bristol Myers Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Canada Ltd filed Critical Bristol Myers Canada Ltd
Priority to CA364,191A priority Critical patent/CA1110252A/en
Priority to CA364,192A priority patent/CA1113466A/en
Application granted granted Critical
Publication of CA1095041A publication Critical patent/CA1095041A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
CA242,795A 1975-01-02 1975-12-30 0-2-isocephem antibacterial agents and processes and intermediates for their production Expired CA1095041A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA364,191A CA1110252A (en) 1975-01-02 1980-11-06 MONOCYCLIC .beta.-LACTAMS AS INTERMEDIATES FOR THE PRODUCTION OF 0-2-ISOCEPHEM ANTIBACTERIAL AGENTS
CA364,192A CA1113466A (en) 1975-01-02 1980-11-06 0-2-isocephem antibacterial agents and processes and intermediates for their production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/538,271 US4012383A (en) 1975-01-02 1975-01-02 Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US538,271 1975-01-02

Publications (1)

Publication Number Publication Date
CA1095041A true CA1095041A (en) 1981-02-03

Family

ID=24146199

Family Applications (2)

Application Number Title Priority Date Filing Date
CA242,795A Expired CA1095041A (en) 1975-01-02 1975-12-30 0-2-isocephem antibacterial agents and processes and intermediates for their production
CA364,190A Expired CA1109873A (en) 1975-01-02 1980-11-06 O-2-isocephem antibacterial agents and processes and intermediates for their production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA364,190A Expired CA1109873A (en) 1975-01-02 1980-11-06 O-2-isocephem antibacterial agents and processes and intermediates for their production

Country Status (7)

Country Link
US (4) US4012383A (enExample)
JP (3) JPS613790B2 (enExample)
BE (1) BE837265A (enExample)
CA (2) CA1095041A (enExample)
DE (1) DE2600039A1 (enExample)
FR (1) FR2296423A1 (enExample)
GB (1) GB1538240A (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172199A (en) * 1975-01-02 1979-10-23 Bristol-Myers Company O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4013648A (en) * 1975-07-23 1977-03-22 Bristol-Myers Company Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents
US4171438A (en) * 1975-07-23 1979-10-16 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
AU516665B2 (en) * 1975-10-06 1981-06-18 Fujisawa Pharmaceutical Co., Ltd 2-azetidone compounds
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4162250A (en) * 1976-09-08 1979-07-24 Smithkline Corporation 3-Aminoazetidinone derivatives
FR2380221A1 (fr) * 1977-02-11 1978-09-08 Ugine Kuhlmann Perfectionnement au procede de preparation du percarbonate de sodium
JPH02111750A (ja) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd 酪酸誘導体
DE2967053D1 (en) * 1978-09-12 1984-07-19 Fujisawa Pharmaceutical Co Starting compounds for preparing cephem compounds and processes for their preparation
DE3069832D1 (en) * 1979-09-13 1985-01-31 Kyowa Hakko Kogyo Kk Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them
US4663450A (en) * 1979-10-25 1987-05-05 Kyowa Hakko Kogyo Co., Ltd. Optically active cephalosporin analogs
FR2505840A1 (fr) * 1981-05-13 1982-11-19 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
JPS58192866A (ja) * 1982-04-30 1983-11-10 Kanegafuchi Chem Ind Co Ltd ２―アゼチジノン誘導体
CA1204746A (en) * 1982-08-19 1986-05-20 Hoffmann-La Roche Limited .beta. LACTAMS
JP2525170B2 (ja) * 1987-03-09 1996-08-14 大塚製薬株式会社 ２―オキサイソセフェム誘導体の製造方法
US8593825B2 (en) * 2009-10-14 2013-11-26 Wintec Industries, Inc. Apparatus and method for vertically-structured passive components
CN103508969A (zh) * 2013-09-09 2014-01-15 南通市华峰化工有限责任公司 一种高纯度5-四氮唑乙酸的合成生产方法
WO2015051921A1 (en) * 2013-10-10 2015-04-16 Merck Patent Gmbh Synthesis of 1-alkyl-2-amino-imidazol-5-carboxylic acid ester via calpha-substituted n-alkyl-glycine ester derivatives
CN114345304A (zh) * 2021-12-30 2022-04-15 北京建工环境修复股份有限公司 一种负载零价铁的纤维素壳聚糖复合微球及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1914366A1 (de) * 1969-03-21 1970-10-01 Bayer Ag Arzneimittel auf Basis neuer,heterocyclischer Verbindungen
CH541577A (de) * 1970-11-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung thiaheterocyclischer Verbindungen
DE2219601A1 (de) 1971-04-27 1972-11-16 Astra Läkemedel AB, Södertälje (Schweden) beta-Lactame und Verfahren zu deren Herstellung
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4136648A (en) * 1976-12-22 1979-01-30 Ford Motor Company Low weight reciprocating engine

Also Published As

Publication number Publication date
FR2296423A1 (fr) 1976-07-30
JPS61197587A (ja) 1986-09-01
US4065623A (en) 1977-12-27
JPS6229435B2 (enExample) 1987-06-25
JPS6229434B2 (enExample) 1987-06-25
FR2296423B1 (enExample) 1978-09-22
US4012383A (en) 1977-03-15
JPS5191293A (enExample) 1976-08-10
CA1109873A (en) 1981-09-29
DE2600039A1 (de) 1976-12-02
US4113946A (en) 1978-09-12
BE837265A (fr) 1976-06-30
JPS613790B2 (enExample) 1986-02-04
US4066831A (en) 1978-01-03
JPS61197586A (ja) 1986-09-01
GB1538240A (en) 1979-01-17

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YOSHIDA et al. STUDIES ON MONOCYCLIC β-LACTAM ANTIBIOTICS II. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 3-ACYLAMINO-2-AZETIDINONE-1-OXYSULFONIC ACIDS
JPS6016989A (ja) オキソ飽和異項環カルボンアミドセフエム化合物
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Legal Events

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