CA1094289A - Aluminum compound and medicament containing it - Google Patents
Aluminum compound and medicament containing itInfo
- Publication number
- CA1094289A CA1094289A CA247,626A CA247626A CA1094289A CA 1094289 A CA1094289 A CA 1094289A CA 247626 A CA247626 A CA 247626A CA 1094289 A CA1094289 A CA 1094289A
- Authority
- CA
- Canada
- Prior art keywords
- sulphate
- aluminum
- polyhydroxy
- phosphate
- hydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052782 aluminium Inorganic materials 0.000 title claims abstract description 27
- -1 Aluminum compound Chemical class 0.000 title claims description 3
- 239000003814 drug Substances 0.000 title description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 25
- FWFGVMYFCODZRD-UHFFFAOYSA-N oxidanium;hydrogen sulfate Chemical class O.OS(O)(=O)=O FWFGVMYFCODZRD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 9
- 229910001868 water Inorganic materials 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 15
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- BUACSMWVFUNQET-UHFFFAOYSA-H dialuminum;trisulfate;hydrate Chemical compound O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O BUACSMWVFUNQET-UHFFFAOYSA-H 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 abstract description 23
- 235000021317 phosphate Nutrition 0.000 abstract description 23
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract description 12
- 238000002360 preparation method Methods 0.000 abstract description 7
- 208000006568 Urinary Bladder Calculi Diseases 0.000 abstract description 5
- 150000004677 hydrates Chemical class 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 2
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 13
- 239000010452 phosphate Substances 0.000 description 13
- 210000002700 urine Anatomy 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 6
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000004575 stone Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 229940118662 aluminum carbonate Drugs 0.000 description 2
- 229940024545 aluminum hydroxide Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 230000036642 wellbeing Effects 0.000 description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical class [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 101100387923 Caenorhabditis elegans dos-1 gene Proteins 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 102000016462 Phosphate Transport Proteins Human genes 0.000 description 1
- 108091007643 Phosphate carriers Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- XIBQUVXDOIQHNW-UHFFFAOYSA-H dialuminum carbonate tetrahydroxide Chemical compound O[Al+]O.O[Al+]O.[O-]C([O-])=O XIBQUVXDOIQHNW-UHFFFAOYSA-H 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F7/00—Compounds of aluminium
- C01F7/68—Aluminium compounds containing sulfur
- C01F7/74—Sulfates
- C01F7/746—After-treatment, e.g. dehydration or stabilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Geology (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Connections Effected By Soldering, Adhesion, Or Permanent Deformation (AREA)
- Coupling Device And Connection With Printed Circuit (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2510663A DE2510663C3 (de) | 1975-03-12 | 1975-03-12 | Aluminiumpolyhydroxisulfat, Verfahren zur Herstellung sowie dieses enthaltendes Arzneimittel |
| DEP2510663.2 | 1975-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1094289A true CA1094289A (en) | 1981-01-27 |
Family
ID=5941086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA247,626A Expired CA1094289A (en) | 1975-03-12 | 1976-03-09 | Aluminum compound and medicament containing it |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4098883A (en, 2012) |
| JP (1) | JPS6028811B2 (en, 2012) |
| AR (1) | AR205501A1 (en, 2012) |
| AT (1) | AT341999B (en, 2012) |
| AU (1) | AU503545B2 (en, 2012) |
| BE (1) | BE839522A (en, 2012) |
| CA (1) | CA1094289A (en, 2012) |
| CH (1) | CH599050A5 (en, 2012) |
| DD (1) | DD124517A1 (en, 2012) |
| DE (1) | DE2510663C3 (en, 2012) |
| DK (1) | DK141696C (en, 2012) |
| ES (1) | ES445893A1 (en, 2012) |
| FI (1) | FI60851C (en, 2012) |
| FR (1) | FR2303553A1 (en, 2012) |
| GB (1) | GB1520991A (en, 2012) |
| GR (1) | GR59902B (en, 2012) |
| HK (1) | HK75079A (en, 2012) |
| IE (1) | IE42783B1 (en, 2012) |
| IT (1) | IT1062446B (en, 2012) |
| LU (1) | LU74522A1 (en, 2012) |
| NL (1) | NL167935C (en, 2012) |
| NO (1) | NO140663C (en, 2012) |
| PH (1) | PH12463A (en, 2012) |
| PT (1) | PT64830B (en, 2012) |
| SE (1) | SE419435B (en, 2012) |
| YU (1) | YU40277B (en, 2012) |
| ZA (1) | ZA761421B (en, 2012) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526772A (en) * | 1981-05-14 | 1985-07-02 | Tokuyama Suda Kabushiki Kaisha | Basic aluminum sulfate and process for production thereof |
| SE434504B (sv) * | 1982-12-09 | 1984-07-30 | Boliden Ab | Forfarande for framstellning av polyaluminiumhydroxidkomplex med sulfat- eller kloridanjon i fast form |
| CH674148A5 (en, 2012) * | 1986-06-24 | 1990-05-15 | Racz Istvan | |
| HU196711B (en) * | 1986-06-24 | 1989-01-30 | Istvan Racz | Process for producing long-acting, gastric acid neutralizing pharmaceutics with high acid-binding capacity and increased bioavailability |
| JPH062580B2 (ja) * | 1988-11-14 | 1994-01-12 | 富田製薬株式会社 | ベーマイト状水酸化アルミニウム、その製造法及びそれを有効成分とする経口用リン酸イオン吸着剤 |
| AU2002332426A1 (en) * | 2001-07-25 | 2003-02-17 | Richard A. Haase | Processes and apparatus for the manufacture of polynuclear aluminum compounds and disinfectants, and polynuclear aluminum compounds and disinfectants from such processes and apparatus |
| US8268269B2 (en) * | 2006-01-24 | 2012-09-18 | Clearvalue Technologies, Inc. | Manufacture of water chemistries |
| RU2617155C1 (ru) * | 2015-12-29 | 2017-04-21 | Общество с ограниченной ответственностью "Метахим" | Способ получения коагулянта на основе полиоксисульфата алюминия, коагулянт, полученный указанным способом |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3544476A (en) * | 1967-05-09 | 1970-12-01 | Taki Fertilizer Mfg Co Ltd | Coagulant and method for treating aqueous medium comprising a basic metal salt and a multivalent anion |
| DK136015B (da) * | 1973-02-09 | 1977-08-01 | Sandoz Ag | Fremgangsmåde til fremstilling af en aluminiumhydrogel til anvendelse som phosphatbindingsmiddel. |
| US3911090A (en) * | 1973-05-14 | 1975-10-07 | Purdue Research Foundation | Aluminum hydroxy carbonates nucleated with silicate anion |
| US3929660A (en) * | 1973-05-29 | 1975-12-30 | Square D Co | Arc-extinguishing materials |
-
1975
- 1975-03-12 DE DE2510663A patent/DE2510663C3/de not_active Expired
-
1976
- 1976-01-01 AR AR262266A patent/AR205501A1/es active
- 1976-02-10 GR GR50011A patent/GR59902B/el unknown
- 1976-02-12 DK DK57176A patent/DK141696C/da not_active IP Right Cessation
- 1976-02-19 AT AT119576A patent/AT341999B/de not_active IP Right Cessation
- 1976-02-20 GB GB6769/76A patent/GB1520991A/en not_active Expired
- 1976-02-20 PT PT64830A patent/PT64830B/pt unknown
- 1976-02-25 FI FI760481A patent/FI60851C/fi not_active IP Right Cessation
- 1976-02-25 SE SE7602359A patent/SE419435B/xx not_active IP Right Cessation
- 1976-02-27 PH PH18150A patent/PH12463A/en unknown
- 1976-03-05 US US05/664,111 patent/US4098883A/en not_active Expired - Lifetime
- 1976-03-08 ZA ZA761421A patent/ZA761421B/xx unknown
- 1976-03-08 IE IE471/76A patent/IE42783B1/en unknown
- 1976-03-09 CA CA247,626A patent/CA1094289A/en not_active Expired
- 1976-03-09 ES ES445893A patent/ES445893A1/es not_active Expired
- 1976-03-10 DD DD191786A patent/DD124517A1/xx unknown
- 1976-03-10 LU LU74522A patent/LU74522A1/xx unknown
- 1976-03-11 NL NL7602553A patent/NL167935C/xx not_active IP Right Cessation
- 1976-03-11 YU YU638/76A patent/YU40277B/xx unknown
- 1976-03-11 NO NO760860A patent/NO140663C/no unknown
- 1976-03-11 IT IT21074/76A patent/IT1062446B/it active
- 1976-03-12 BE BE165127A patent/BE839522A/xx not_active IP Right Cessation
- 1976-03-12 JP JP51027018A patent/JPS6028811B2/ja not_active Expired
- 1976-03-12 CH CH313176A patent/CH599050A5/xx not_active IP Right Cessation
- 1976-03-12 FR FR7607147A patent/FR2303553A1/fr active Granted
- 1976-03-12 AU AU11972/76A patent/AU503545B2/en not_active Expired
-
1979
- 1979-10-25 HK HK750/79A patent/HK75079A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |