CA1091350A - Particle-density measuring system - Google Patents
Particle-density measuring systemInfo
- Publication number
- CA1091350A CA1091350A CA289,075A CA289075A CA1091350A CA 1091350 A CA1091350 A CA 1091350A CA 289075 A CA289075 A CA 289075A CA 1091350 A CA1091350 A CA 1091350A
- Authority
- CA
- Canada
- Prior art keywords
- pulses
- particles
- particle
- electrical
- count
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002245 particle Substances 0.000 title claims abstract description 246
- 210000001772 blood platelet Anatomy 0.000 claims abstract description 216
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 190
- 210000004369 blood Anatomy 0.000 claims abstract description 57
- 239000008280 blood Substances 0.000 claims abstract description 57
- 238000000034 method Methods 0.000 claims abstract description 56
- 230000000875 corresponding effect Effects 0.000 claims description 98
- 239000012530 fluid Substances 0.000 claims description 41
- 238000001514 detection method Methods 0.000 claims description 26
- 238000003860 storage Methods 0.000 claims description 4
- 230000000007 visual effect Effects 0.000 claims description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 12
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 51
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 35
- 210000004027 cell Anatomy 0.000 description 27
- 230000008569 process Effects 0.000 description 21
- 238000004820 blood count Methods 0.000 description 20
- 238000005534 hematocrit Methods 0.000 description 20
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- 239000012895 dilution Substances 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000004020 conductor Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 210000000601 blood cell Anatomy 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 2
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- 230000007423 decrease Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 206010000830 Acute leukaemia Diseases 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 239000012898 sample dilution Substances 0.000 description 1
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- 238000004513 sizing Methods 0.000 description 1
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- 201000008827 tuberculosis Diseases 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G01N15/132—Circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/018—Platelets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1024—Counting particles by non-optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1029—Particle size
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73889676A | 1976-11-04 | 1976-11-04 | |
| US738,896 | 1976-11-04 | ||
| US05/832,893 US4110604A (en) | 1976-11-04 | 1977-09-13 | Particle density measuring system |
| US832,893 | 1977-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1091350A true CA1091350A (en) | 1980-12-09 |
Family
ID=27113441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA289,075A Expired CA1091350A (en) | 1976-11-04 | 1977-10-19 | Particle-density measuring system |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5377584A (ja) |
| AU (1) | AU504450B2 (ja) |
| CA (1) | CA1091350A (ja) |
| DE (1) | DE2748923C2 (ja) |
| FR (1) | FR2370276A1 (ja) |
| GB (1) | GB1588170A (ja) |
| IT (1) | IT1087196B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447883A (en) * | 1981-05-26 | 1984-05-08 | Technicon Instruments Corporation | Coincidence-error correcting apparatus and method |
| DE3227664A1 (de) * | 1982-07-23 | 1984-02-02 | Vladimir Vasil'evič Saratov Pavlov | Einrichtung zur messung der menge und groesse fester teilchen in fluessigen und gasmedien |
| GB8410500D0 (en) * | 1984-04-25 | 1984-05-31 | Orbec Ltd | Monitoring particles in liquids |
| JPH0736269Y2 (ja) * | 1985-07-26 | 1995-08-16 | 日本光電工業株式会社 | 液体中の粒子計測装置 |
| EP0529666B1 (en) * | 1991-08-30 | 2000-04-12 | Omron Corporation | Cell analyzing apparatus |
| US5488469A (en) * | 1991-08-30 | 1996-01-30 | Omron Corporation | Cell analyzing apparatus |
| US8023592B2 (en) * | 2005-08-24 | 2011-09-20 | Beckman Coulter, Inc. | Method and apparatus for finding center amplitude of particle size-representative pulses produced by aperture based sizing system |
| DE102006021487B3 (de) | 2006-05-05 | 2007-09-06 | Parsum Gmbh | Verfahren und Vorrichtung zur Bestimmung der in einem Partikelstrom enthaltenen Partikel |
| CN112557281B (zh) * | 2020-11-23 | 2022-06-24 | 深圳市科曼医疗设备有限公司 | 血液细胞分析仪的plt粒子检测方法和装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1118510B (de) * | 1958-11-25 | 1961-11-30 | Boskamp Geraete Bau K G | Elektrisches Registriergeraet zur quantitativen Auswertung des Differential-Blutbildes |
| US3810011A (en) * | 1970-05-25 | 1974-05-07 | Coulter Electronics | Apparatus and method for analyzing the particle volume distribution for a plurality of particles of different size in a quantity of liquid |
| DE2134937C2 (de) * | 1971-07-13 | 1982-08-05 | Bio-Physics Systems, Inc., Baldwin Place, N.Y. | Verfahren und Vorrichtung zum Erfassen von in einer Flüssigkeit suspendierten Teilchen |
-
1977
- 1977-10-19 CA CA289,075A patent/CA1091350A/en not_active Expired
- 1977-10-20 GB GB43729/77A patent/GB1588170A/en not_active Expired
- 1977-10-26 AU AU30078/77A patent/AU504450B2/en not_active Expired
- 1977-11-02 DE DE2748923A patent/DE2748923C2/de not_active Expired
- 1977-11-03 IT IT29306/77A patent/IT1087196B/it active
- 1977-11-03 FR FR7733066A patent/FR2370276A1/fr active Granted
- 1977-11-04 JP JP13240077A patent/JPS5377584A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1588170A (en) | 1981-04-15 |
| DE2748923A1 (de) | 1978-05-11 |
| AU504450B2 (en) | 1979-10-11 |
| DE2748923C2 (de) | 1982-05-13 |
| JPS5377584A (en) | 1978-07-10 |
| IT1087196B (it) | 1985-05-31 |
| FR2370276B1 (ja) | 1981-12-04 |
| AU3007877A (en) | 1979-06-07 |
| FR2370276A1 (fr) | 1978-06-02 |
| JPS627966B2 (ja) | 1987-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |