CA1089448A - Process for purifying glucagon - Google Patents

Process for purifying glucagon

Info

Publication number
CA1089448A
CA1089448A CA275,504A CA275504A CA1089448A CA 1089448 A CA1089448 A CA 1089448A CA 275504 A CA275504 A CA 275504A CA 1089448 A CA1089448 A CA 1089448A
Authority
CA
Canada
Prior art keywords
glucagon
percent
column
gel
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA275,504A
Other languages
English (en)
French (fr)
Inventor
John G. Stilz
Richard L. Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1089448A publication Critical patent/CA1089448A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA275,504A 1975-12-17 1977-04-04 Process for purifying glucagon Expired CA1089448A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/641,419 US4033941A (en) 1975-12-17 1975-12-17 Process for purifying glucagon

Publications (1)

Publication Number Publication Date
CA1089448A true CA1089448A (en) 1980-11-11

Family

ID=24572291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA275,504A Expired CA1089448A (en) 1975-12-17 1977-04-04 Process for purifying glucagon

Country Status (7)

Country Link
US (1) US4033941A (https=)
CA (1) CA1089448A (https=)
DE (1) DE2721027A1 (https=)
FR (1) FR2389598B1 (https=)
GB (1) GB1576344A (https=)
NL (1) NL7703758A (https=)
SE (1) SE443512B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1284000C (en) * 1985-07-01 1991-05-07 David Gregory Maskalick Process for recovering glucagon from pancreas glands
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
DK2074141T3 (en) * 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
US9387176B2 (en) * 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
AU2008257505B2 (en) * 2007-06-01 2013-05-16 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
WO2009112583A2 (en) * 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
EP3517543B1 (en) 2018-01-30 2020-11-04 Bachem AG Manufacture of glucagon peptides
CN113024658B (zh) * 2019-12-25 2022-10-21 翰宇药业（武汉）有限公司 一种纯化利拉鲁肽的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3715345A (en) * 1970-08-03 1973-02-06 Lilly Co Eli Glucagon separation process
DE2258080C3 (de) * 1972-11-27 1981-12-17 Eli Lilly And Co., Indianapolis, Ind. Verfahren zur Gewinnung von Hexatriacontapeptiden
US3878186A (en) * 1973-05-09 1975-04-15 Lilly Co Eli Process for purifying insulin
US3875138A (en) * 1973-09-27 1975-04-01 Lilly Co Eli Process for recovering glucagon

Also Published As

Publication number Publication date
FR2389598B1 (https=) 1981-06-19
FR2389598A1 (https=) 1978-12-01
US4033941A (en) 1977-07-05
SE443512B (sv) 1986-03-03
SE7705162L (sv) 1978-11-04
DE2721027A1 (de) 1978-11-16
NL7703758A (nl) 1978-10-09
GB1576344A (en) 1980-10-08

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Legal Events

Date Code Title Description
MKEX Expiry