DK3517543T3 - Fremstilling af glucagonpeptider - Google Patents
Fremstilling af glucagonpeptider Download PDFInfo
- Publication number
- DK3517543T3 DK3517543T3 DK18154113.7T DK18154113T DK3517543T3 DK 3517543 T3 DK3517543 T3 DK 3517543T3 DK 18154113 T DK18154113 T DK 18154113T DK 3517543 T3 DK3517543 T3 DK 3517543T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- glucagon peptides
- glucagon
- peptides
- Prior art date
Links
- 102400000321 Glucagon Human genes 0.000 title 1
- 108060003199 Glucagon Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18154113.7A EP3517543B1 (en) | 2018-01-30 | 2018-01-30 | Manufacture of glucagon peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3517543T3 true DK3517543T3 (da) | 2020-12-07 |
Family
ID=61198669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18154113.7T DK3517543T3 (da) | 2018-01-30 | 2018-01-30 | Fremstilling af glucagonpeptider |
| DK19701672.8T DK3746466T5 (da) | 2018-01-30 | 2019-01-30 | Fremstilling af glucagonpeptider |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19701672.8T DK3746466T5 (da) | 2018-01-30 | 2019-01-30 | Fremstilling af glucagonpeptider |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210122782A1 (da) |
| EP (2) | EP3517543B1 (da) |
| JP (1) | JP7360397B2 (da) |
| CN (1) | CN111670194B (da) |
| DK (2) | DK3517543T3 (da) |
| IL (1) | IL276067B2 (da) |
| WO (1) | WO2019149723A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220324936A1 (en) * | 2019-06-18 | 2022-10-13 | Fresenius Kabi Ipsum S.R.L. | Process for the manufacture of glucagon |
| CN113045640B (zh) * | 2019-12-27 | 2023-03-24 | 翰宇药业（武汉）有限公司 | 一种glp-1类似物的纯化方法 |
| JP2023523823A (ja) | 2020-05-01 | 2023-06-07 | カシーヴ バイオサイエンシズ，リミテッド・ライアビリティ・カンパニー | タンパク質の精製の改善されたプロセス |
| AR122579A1 (es) * | 2020-06-12 | 2022-09-21 | Lilly Co Eli | Proceso para preparar un agonista dual glp-1 / glucagón |
| CN111732650B (zh) * | 2020-08-04 | 2020-12-08 | 苏州金顶生物有限公司 | 索马鲁肽的连续流固相反应制备 |
| CN112986440A (zh) * | 2021-03-02 | 2021-06-18 | 吉尔多肽生物制药(大连市)有限公司 | 一种Fmoc-Cys(trt)-OH有关物质的检测方法 |
| AU2023239069A1 (en) * | 2022-03-23 | 2024-11-07 | Kashiv Biosciences, Llc | An improved process for the separation and analysis of pancreatic enzymes |
| EP4345104B1 (en) * | 2022-09-30 | 2024-08-28 | Bachem Holding AG | Method for preparing liraglutide |
| CN120641195A (zh) * | 2022-12-22 | 2025-09-12 | 伊莱利利公司 | 减少蛋白纯化中污染物的方法 |
| CA3231829A1 (en) * | 2023-03-17 | 2025-07-08 | Nouryon Chemicals Int Bv | A novel stationary phase for large scale reverse-phase hplc purification |
| CN117330659B (zh) * | 2023-09-13 | 2024-05-31 | 南京汉欣医药科技有限公司 | 一种检测四肽非活化酯异构体的高效液相色谱分析方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033941A (en) | 1975-12-17 | 1977-07-05 | Eli Lilly And Company | Process for purifying glucagon |
| KR0149955B1 (ko) | 1995-11-09 | 1999-03-30 | 김용구 | 융합단백질을 이용한 인간 글루카곤의 제조방법 |
| JP5274771B2 (ja) | 2003-04-08 | 2013-08-28 | ノヴォ ノルディスク アー／エス | クロマトグラフィー固定相の再生 |
| JP2007526235A (ja) * | 2003-08-21 | 2007-09-13 | ノボ ノルディスク アクティーゼルスカブ | グルカゴン様ペプチドの精製 |
| JO2937B1 (en) * | 2004-08-11 | 2016-03-15 | فيرينغ.بي.في | Tight muscles of the peptide vascular tensioner receptor |
| US7265092B2 (en) * | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| JP2010531828A (ja) * | 2007-06-29 | 2010-09-30 | ロンザ アーゲー | プラムリンチドの製造方法 |
| US8153815B2 (en) * | 2008-10-07 | 2012-04-10 | Hoffman-La Roche Inc. | Pseudoproline dipeptides |
| AU2008365559B2 (en) * | 2008-12-15 | 2016-02-25 | Zealand Pharma A/S | Glucagon analogues |
| EP2314616A1 (en) * | 2009-10-23 | 2011-04-27 | Ferring B.V. | Peptidic GLP-2 agonists |
| CN103333239B (zh) | 2013-07-11 | 2015-06-17 | 上海昂博生物技术有限公司 | 固相合成胰高血糖素 |
| CN103694338B (zh) | 2013-12-20 | 2018-04-06 | 深圳翰宇药业股份有限公司 | 一种盐酸高血糖素的纯化方法 |
| WO2016005960A1 (en) * | 2014-07-11 | 2016-01-14 | Dr. Reddy's Laboratories Limited | Process for preparation of liraglutide |
| US10690635B2 (en) * | 2016-03-23 | 2020-06-23 | Bachem Holding Ag | Purification of glucagon-like peptide 1 analogs |
| EP3433267B1 (en) * | 2016-03-23 | 2022-08-24 | Bachem Holding AG | Method for preparing glucagon-like peptides |
| US20170313740A1 (en) * | 2016-04-28 | 2017-11-02 | C S Bio Co. | Methods of preparing peptides |
| EP3753946A1 (en) * | 2019-06-18 | 2020-12-23 | Fresenius Kabi iPSUM S.r.l. | Improved process for the preparation of high purity glucagon |
| US20220324936A1 (en) * | 2019-06-18 | 2022-10-13 | Fresenius Kabi Ipsum S.R.L. | Process for the manufacture of glucagon |
-
2018
- 2018-01-30 EP EP18154113.7A patent/EP3517543B1/en active Active
- 2018-01-30 DK DK18154113.7T patent/DK3517543T3/da active
-
2019
- 2019-01-30 US US16/962,793 patent/US20210122782A1/en active Pending
- 2019-01-30 IL IL276067A patent/IL276067B2/en unknown
- 2019-01-30 JP JP2020561947A patent/JP7360397B2/ja active Active
- 2019-01-30 EP EP19701672.8A patent/EP3746466B1/en active Active
- 2019-01-30 CN CN201980010992.7A patent/CN111670194B/zh active Active
- 2019-01-30 DK DK19701672.8T patent/DK3746466T5/da active
- 2019-01-30 WO PCT/EP2019/052183 patent/WO2019149723A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DK3746466T5 (da) | 2024-08-26 |
| IL276067B2 (en) | 2024-12-01 |
| EP3517543B1 (en) | 2020-11-04 |
| JP2021512157A (ja) | 2021-05-13 |
| JP7360397B2 (ja) | 2023-10-12 |
| IL276067A (en) | 2020-08-31 |
| US20210122782A1 (en) | 2021-04-29 |
| DK3746466T3 (da) | 2023-01-23 |
| CN111670194B (zh) | 2024-01-26 |
| IL276067B1 (en) | 2024-08-01 |
| WO2019149723A1 (en) | 2019-08-08 |
| EP3746466A1 (en) | 2020-12-09 |
| EP3517543A1 (en) | 2019-07-31 |
| EP3746466B1 (en) | 2022-11-23 |
| CN111670194A (zh) | 2020-09-15 |
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