CA1080500A - Method and a composition for reducing the dose of a biologically active substance while maintaining its biological effect - Google Patents
Method and a composition for reducing the dose of a biologically active substance while maintaining its biological effectInfo
- Publication number
- CA1080500A CA1080500A CA 265827 CA265827A CA1080500A CA 1080500 A CA1080500 A CA 1080500A CA 265827 CA265827 CA 265827 CA 265827 A CA265827 A CA 265827A CA 1080500 A CA1080500 A CA 1080500A
- Authority
- CA
- Canada
- Prior art keywords
- carrier
- active substance
- biologically active
- composition
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000002297 parasiticide Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
- 235000019354 vermiculite Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
- A61L9/046—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating with the help of a non-organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/651—The particulate/core comprising inorganic material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7607389A SE421042B (sv) | 1976-06-29 | 1976-06-29 | Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1080500A true CA1080500A (en) | 1980-07-01 |
Family
ID=20328328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 265827 Expired CA1080500A (en) | 1976-06-29 | 1976-11-16 | Method and a composition for reducing the dose of a biologically active substance while maintaining its biological effect |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS533512A (en:Method) |
| AR (1) | AR221686A1 (en:Method) |
| AU (1) | AU2611177A (en:Method) |
| BE (1) | BE848892A (en:Method) |
| CA (1) | CA1080500A (en:Method) |
| DD (1) | DD130984A5 (en:Method) |
| DE (1) | DE2652163A1 (en:Method) |
| DK (1) | DK518476A (en:Method) |
| ES (1) | ES460159A1 (en:Method) |
| FI (1) | FI61637C (en:Method) |
| FR (1) | FR2356430A1 (en:Method) |
| GB (1) | GB1572718A (en:Method) |
| GR (1) | GR63669B (en:Method) |
| IL (1) | IL52243A (en:Method) |
| IN (1) | IN145766B (en:Method) |
| IT (1) | IT1064524B (en:Method) |
| LU (1) | LU76238A1 (en:Method) |
| MC (1) | MC1116A1 (en:Method) |
| NL (1) | NL7613404A (en:Method) |
| NO (1) | NO146974C (en:Method) |
| PL (1) | PL199237A1 (en:Method) |
| PT (1) | PT66663B (en:Method) |
| SE (1) | SE421042B (en:Method) |
| ZA (1) | ZA773259B (en:Method) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6026093B2 (ja) * | 1978-03-14 | 1985-06-21 | 住友製薬株式会社 | ゲフアルナート含有固型製剤の製造方法 |
| IT1103817B (it) * | 1978-06-27 | 1985-10-14 | Guaber Spa | Composizione deodorante granulare per posacenere |
| IT1144023B (it) * | 1979-12-21 | 1986-10-29 | Glaxo Group Ltd | Mescola contenente cefalessina da incapsulare e relativo procedimento di produzione |
| DK204682A (da) * | 1981-05-08 | 1982-11-09 | Wellcome Found | Parfumeafgivende materiale |
| NZ204861A (en) * | 1982-07-20 | 1986-10-08 | Nat Res Dev | Sustained release device:trace element incorporated in cement |
| HU191244B (en) * | 1984-01-06 | 1987-01-28 | Egyt Gyogyszervegyeszeti Gyar | Dust mixture of high propylene-glycol content and process for producing same |
| HU191245B (en) * | 1984-01-06 | 1987-01-28 | Egis Gyogyszergyar,Hu | Process for the production of stbale pharmaceutical preparation against ketosis |
| GB8413191D0 (en) * | 1984-05-23 | 1984-06-27 | Beecham Group Plc | Pharmaceutical composition |
| EP0215136B1 (de) * | 1985-09-02 | 1988-06-22 | Artesan Pharma Gesellschaft mit beschränkter Haftung | Hexetidin 1,3-Bis-(2-ethylhexyl)-hexahydro-5-methyl-5-pyrimidinamin enthaltendes therapeutisch wirkendes Mittel, sowie Verfahren zum Herstellen desselben und Verwendung als vaginales Desinfektionsmittel |
| GB8713263D0 (en) * | 1987-06-05 | 1987-07-08 | Unilever Plc | Spheroidal silica |
| JPH08505368A (ja) * | 1992-10-30 | 1996-06-11 | ビー・エイ・エス・エフ、コーポレーション | 粒状の水溶性または吸湿性の農業用配合物およびその製造法 |
| DE19506141A1 (de) * | 1995-02-22 | 1996-08-29 | Hoechst Ag | Verwendung von Aerogelen in der Pharmazie, in der Kosmetik und im Pflanzenschutz |
| AU2893097A (en) * | 1996-04-29 | 1997-11-19 | Agricultural Academy Of Krakow | Oral delivery form having a high absorption efficiency and method for making same |
| SG71877A1 (en) * | 1997-12-19 | 2000-04-18 | Johnson & Johnson Consumer | Novel powder compositions |
| DE69942205D1 (de) * | 1998-08-13 | 2010-05-12 | Cima Labs Inc | Microemulsionen als feste dosisformen zur oralen verabreichung |
| EP2421508B1 (en) * | 2009-04-24 | 2016-12-14 | Omya International AG | Particulate material for controlled release of active ingredients |
| WO2014078435A1 (en) | 2012-11-14 | 2014-05-22 | W. R. Grace & Co.-Conn. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5235736B2 (en:Method) * | 1972-09-27 | 1977-09-10 |
-
1976
- 1976-06-29 SE SE7607389A patent/SE421042B/xx unknown
- 1976-11-16 DE DE19762652163 patent/DE2652163A1/de not_active Withdrawn
- 1976-11-16 CA CA 265827 patent/CA1080500A/en not_active Expired
- 1976-11-17 DK DK518476A patent/DK518476A/da unknown
- 1976-11-18 NO NO763947A patent/NO146974C/no unknown
- 1976-11-18 FI FI763304A patent/FI61637C/fi not_active IP Right Cessation
- 1976-11-19 LU LU76238A patent/LU76238A1/xx unknown
- 1976-11-19 GB GB48278/76A patent/GB1572718A/en not_active Expired
- 1976-11-29 BE BE172830A patent/BE848892A/xx unknown
- 1976-12-02 NL NL7613404A patent/NL7613404A/xx unknown
- 1976-12-02 IT IT30032/76A patent/IT1064524B/it active
- 1976-12-03 FR FR7636578A patent/FR2356430A1/fr active Granted
- 1976-12-03 MC MC761221A patent/MC1116A1/xx unknown
-
1977
- 1977-01-24 JP JP670477A patent/JPS533512A/ja active Pending
- 1977-05-28 IN IN806/CAL/77A patent/IN145766B/en unknown
- 1977-05-30 ZA ZA00773259A patent/ZA773259B/xx unknown
- 1977-06-01 GR GR53602A patent/GR63669B/el unknown
- 1977-06-03 IL IL52243A patent/IL52243A/xx unknown
- 1977-06-14 PT PT66663A patent/PT66663B/pt unknown
- 1977-06-15 AU AU26111/77A patent/AU2611177A/en not_active Expired
- 1977-06-22 AR AR268151A patent/AR221686A1/es active
- 1977-06-27 DD DD7700199726A patent/DD130984A5/xx unknown
- 1977-06-28 ES ES460159A patent/ES460159A1/es not_active Expired
- 1977-06-29 PL PL19923777A patent/PL199237A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7613404A (nl) | 1978-01-02 |
| AU2611177A (en) | 1978-12-21 |
| JPS533512A (en) | 1978-01-13 |
| DD130984A5 (de) | 1978-05-24 |
| DE2652163A1 (de) | 1978-01-12 |
| LU76238A1 (en:Method) | 1977-05-23 |
| ZA773259B (en) | 1978-04-26 |
| BE848892A (fr) | 1977-03-16 |
| SE7607389L (sv) | 1977-12-30 |
| FI61637B (fi) | 1982-05-31 |
| ES460159A1 (es) | 1978-10-01 |
| NO146974B (no) | 1982-10-04 |
| FR2356430B1 (en:Method) | 1982-08-13 |
| NO146974C (no) | 1983-01-26 |
| PT66663B (en) | 1978-11-13 |
| SE421042B (sv) | 1981-11-23 |
| PL199237A1 (pl) | 1979-07-02 |
| DK518476A (da) | 1977-12-30 |
| FR2356430A1 (fr) | 1978-01-27 |
| IL52243A (en) | 1980-10-26 |
| IN145766B (en:Method) | 1978-12-16 |
| FI763304A7 (en:Method) | 1977-12-30 |
| GR63669B (en) | 1979-11-28 |
| IT1064524B (it) | 1985-02-18 |
| GB1572718A (en) | 1980-07-30 |
| MC1116A1 (fr) | 1977-08-12 |
| AR221686A1 (es) | 1981-03-13 |
| PT66663A (en) | 1977-07-01 |
| NO763947L (no) | 1977-12-30 |
| FI61637C (fi) | 1982-09-10 |
| IL52243A0 (en) | 1977-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |