CA1074338A - Aryloxyaminobutanol derivatives and a process for the preparation thereof - Google Patents

Aryloxyaminobutanol derivatives and a process for the preparation thereof

Info

Publication number
CA1074338A
CA1074338A CA220,429A CA220429A CA1074338A CA 1074338 A CA1074338 A CA 1074338A CA 220429 A CA220429 A CA 220429A CA 1074338 A CA1074338 A CA 1074338A
Authority
CA
Canada
Prior art keywords
compound
general formula
variant
stands
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA220,429A
Other languages
English (en)
French (fr)
Inventor
Kalman Harsanyi
Dezso Korbonits
Erzsebet Molnar
Jozsef Szegi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of CA1074338A publication Critical patent/CA1074338A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA220,429A 1974-02-20 1975-02-19 Aryloxyaminobutanol derivatives and a process for the preparation thereof Expired CA1074338A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1449A HU169464B (US06623731-20030923-C00052.png) 1974-02-20 1974-02-20

Publications (1)

Publication Number Publication Date
CA1074338A true CA1074338A (en) 1980-03-25

Family

ID=10994508

Family Applications (1)

Application Number Title Priority Date Filing Date
CA220,429A Expired CA1074338A (en) 1974-02-20 1975-02-19 Aryloxyaminobutanol derivatives and a process for the preparation thereof

Country Status (22)

Country Link
JP (1) JPS5929063B2 (US06623731-20030923-C00052.png)
AT (1) AT339281B (US06623731-20030923-C00052.png)
BE (1) BE825745A (US06623731-20030923-C00052.png)
BG (2) BG26366A3 (US06623731-20030923-C00052.png)
CA (1) CA1074338A (US06623731-20030923-C00052.png)
CH (1) CH619684A5 (US06623731-20030923-C00052.png)
CS (1) CS199578B2 (US06623731-20030923-C00052.png)
DD (1) DD119414A5 (US06623731-20030923-C00052.png)
DE (1) DE2506355C2 (US06623731-20030923-C00052.png)
DK (1) DK141935B (US06623731-20030923-C00052.png)
ES (2) ES434784A1 (US06623731-20030923-C00052.png)
FI (1) FI61304C (US06623731-20030923-C00052.png)
FR (1) FR2261001B1 (US06623731-20030923-C00052.png)
GB (1) GB1457086A (US06623731-20030923-C00052.png)
HU (1) HU169464B (US06623731-20030923-C00052.png)
IL (1) IL46634A (US06623731-20030923-C00052.png)
NL (1) NL182698C (US06623731-20030923-C00052.png)
NO (1) NO141754C (US06623731-20030923-C00052.png)
PL (2) PL99025B1 (US06623731-20030923-C00052.png)
SE (1) SE433935B (US06623731-20030923-C00052.png)
SU (1) SU1025327A3 (US06623731-20030923-C00052.png)
YU (2) YU36916B (US06623731-20030923-C00052.png)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48309A (en) * 1974-10-25 1980-01-31 Robins Co Inc A H 1-aryloxy-4-amino-2-butanols and pharmaceutical compositions containing them
EP0097000B1 (en) * 1982-06-10 1987-09-09 Beecham Wuelfing GmbH & Co KG Amine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1957706C3 (de) * 1968-11-18 1978-06-29 Pfizer Corp., Colon (Panama) Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis
GB1245148A (en) * 1968-11-18 1971-09-08 Pfizer Ltd Propanolamine derivatives
SE384853B (sv) * 1972-04-04 1976-05-24 Haessle Ab Forfarande for framstellning av nya aminer
CH556818A (de) * 1969-09-24 1974-12-13 Ici Ltd Verfahren zur herstellung von alkanolaminderivaten.

Also Published As

Publication number Publication date
YU167681A (en) 1983-04-27
FR2261001B1 (US06623731-20030923-C00052.png) 1978-07-21
FR2261001A1 (US06623731-20030923-C00052.png) 1975-09-12
IL46634A (en) 1979-01-31
JPS5929063B2 (ja) 1984-07-18
CH619684A5 (en) 1980-10-15
IL46634A0 (en) 1975-04-25
JPS50117728A (US06623731-20030923-C00052.png) 1975-09-16
SU1025327A3 (ru) 1983-06-23
ATA114075A (de) 1977-02-15
SE7501801L (US06623731-20030923-C00052.png) 1975-08-21
DD119414A5 (US06623731-20030923-C00052.png) 1976-04-20
FI61304C (fi) 1982-07-12
NO141754B (no) 1980-01-28
DK141935C (US06623731-20030923-C00052.png) 1980-12-08
BG26367A4 (bg) 1979-03-15
ES453326A1 (es) 1977-11-16
PL99023B1 (pl) 1978-06-30
NO141754C (no) 1980-05-07
YU37116B (en) 1984-08-31
NO750566L (US06623731-20030923-C00052.png) 1975-08-21
CS199578B2 (en) 1980-07-31
HU169464B (US06623731-20030923-C00052.png) 1976-11-28
ES434784A1 (es) 1977-03-16
DK141935B (da) 1980-07-21
BG26366A3 (bg) 1979-03-15
FI750443A (US06623731-20030923-C00052.png) 1975-08-21
DK60875A (US06623731-20030923-C00052.png) 1975-10-20
NL7501951A (nl) 1975-08-22
FI61304B (fi) 1982-03-31
BE825745A (fr) 1975-06-16
NL182698C (nl) 1988-05-02
SE433935B (sv) 1984-06-25
DE2506355C2 (de) 1983-10-06
PL99025B1 (pl) 1978-06-30
DE2506355A1 (de) 1975-08-21
YU37375A (en) 1982-06-18
YU36916B (en) 1984-08-31
GB1457086A (en) 1976-12-01
AT339281B (de) 1977-10-10

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