CA1051899A - Composes de la vincamine - Google Patents

Composes de la vincamine

Info

Publication number
CA1051899A
CA1051899A CA216,230A CA216230A CA1051899A CA 1051899 A CA1051899 A CA 1051899A CA 216230 A CA216230 A CA 216230A CA 1051899 A CA1051899 A CA 1051899A
Authority
CA
Canada
Prior art keywords
vincamine
formula
methoxy
compound
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA216,230A
Other languages
English (en)
Inventor
Paul Pfaffli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1768973A external-priority patent/CH588488A5/de
Priority claimed from CH162174A external-priority patent/CH596207A5/de
Priority claimed from CH176574A external-priority patent/CH593283A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1051899A publication Critical patent/CA1051899A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA216,230A 1973-12-18 1974-12-17 Composes de la vincamine Expired CA1051899A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1768973A CH588488A5 (en) 1973-12-18 1973-12-18 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv
CH162174A CH596207A5 (en) 1974-02-06 1974-02-06 Vincamine derivs for treating behaviour disorders
CH176574A CH593283A5 (en) 1974-02-08 1974-02-08 Vincamine derivs for treating behaviour disorders - by ring closure of indoloquinolizine deriv

Publications (1)

Publication Number Publication Date
CA1051899A true CA1051899A (fr) 1979-04-03

Family

ID=27173122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA216,230A Expired CA1051899A (fr) 1973-12-18 1974-12-17 Composes de la vincamine

Country Status (16)

Country Link
JP (1) JPS5817474B2 (fr)
CA (1) CA1051899A (fr)
DD (1) DD116043A5 (fr)
DE (1) DE2458164A1 (fr)
DK (1) DK139358B (fr)
ES (3) ES432952A1 (fr)
FI (1) FI59096C (fr)
FR (1) FR2254342B1 (fr)
GB (1) GB1492579A (fr)
HK (1) HK53980A (fr)
IE (1) IE40791B1 (fr)
MY (1) MY8100186A (fr)
NL (1) NL7416237A (fr)
NO (1) NO744456L (fr)
PH (1) PH12927A (fr)
SE (1) SE422798B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2396759A1 (fr) * 1977-07-06 1979-02-02 Omnium Chimique Sa Nouveaux composes heterocycliques, derives de la vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires ou respiratoires
HU177498B (en) * 1977-07-27 1981-10-28 Richter Gedeon Vegyeszet Process for preparing new vincinic acid and apovincinic acid esters
FR2423493A1 (fr) * 1977-10-19 1979-11-16 Omnium Chimique Sa Nouveaux composes heterocycliques derives de l'apo-vincamine, leur preparation et leur application comme medicaments, notamment dans le domaine des insuffisances cardio-circulatoires, cerebro-vasculaires et respiratoires
FR2407931A1 (fr) * 1977-11-02 1979-06-01 Synthelabo Derives de l'eburnamenine et leur application en therapeutique
JPS5493000A (en) * 1977-12-28 1979-07-23 Sandoz Ag Improvement of organic compound
DE2800063A1 (de) * 1978-01-02 1979-07-12 Sandoz Ag 10-bromvincamin, seine herstellung und verwendung
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
US4283401A (en) * 1978-07-12 1981-08-11 Richter Gedeon Vegyeszeti Gyar Rt Process for the preparation of 11-bromo-vincaminic acid ester derivatives and their use in protecting animals against cerebral hypoxy
US4285949A (en) * 1978-12-11 1981-08-25 Omnichem Societe Anonyme Vincamine derivatives, their preparation and therapeutical use
HU177732B (en) * 1978-12-15 1981-12-28 Richter Gedeon Vegyeszet Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
HU180928B (en) * 1979-08-06 1983-05-30 Richter Gedeon Vegyeszet Process for preparing new brominated 15-hydroxy-e-homo-eburane derivatives
HU180929B (en) * 1979-08-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing new bromo-vincamone derivatives
HU185305B (en) * 1981-08-23 1985-01-28 Richter Gedeon Vegyeszet Process for preparing vincine and apovincine
HU183326B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted in the a ring and acid addition salts thereof
ES8604952A1 (es) * 1985-11-05 1986-03-16 Covex Sa Procedimiento para la preparacion de los compuestos 10-11 bromo-14,15-dihidro-14 b-hidroxi-(3x,16x)-eburnamenina-14- carboxilato de metilo
US4883876A (en) * 1987-09-07 1989-11-28 Taisho Pharmaceutical Co., Ltd. Acylated vincaminic acid derivatives

Also Published As

Publication number Publication date
DE2458164A1 (de) 1975-06-26
FI355274A (fr) 1975-06-19
SE7415416L (fr) 1975-06-19
ES432952A1 (es) 1977-02-16
DK139358B (da) 1979-02-05
DE2458164C2 (fr) 1991-04-18
FR2254342A1 (fr) 1975-07-11
JPS50105700A (fr) 1975-08-20
SE422798B (sv) 1982-03-29
DK639774A (fr) 1975-08-25
FR2254342B1 (fr) 1978-07-21
HK53980A (en) 1980-10-03
ES450740A1 (es) 1977-12-16
FI59096B (fi) 1981-02-27
PH12927A (en) 1979-10-10
AU7648374A (en) 1976-06-17
JPS5817474B2 (ja) 1983-04-07
GB1492579A (en) 1977-11-23
IE40791L (en) 1975-06-18
NO744456L (fr) 1975-07-14
MY8100186A (en) 1981-12-31
DD116043A5 (fr) 1975-11-05
FI59096C (fi) 1981-06-10
IE40791B1 (en) 1979-08-15
NL7416237A (nl) 1975-06-20
DK139358C (fr) 1979-07-09
ES450741A1 (es) 1978-03-16

Similar Documents

Publication Publication Date Title
CA1051899A (fr) Composes de la vincamine
US4146643A (en) Increasing vigilance or treating cerebral insufficiency with substituted vincamines
Brenner et al. Synthesis of arcyriarubin b and related bisindolylmaleimides
Newkome et al. On the reaction of lithium diisopropylamide with. pi.-deficient heteroaromatics. A single electron transfer mechanism
Gay et al. Lithiations of. alpha.-and. beta.-(dimethylaminomethyl) naphthalenes with n-butyllithium and condensations with benzophenone. Some related results
Jacobi et al. Bis heteroannulation. 4. Facile syntheses of methylene acids, methylbutenolides,. alpha.-methyl-. gamma.-lactones, and related materials. Total syntheses of (.+-.)-ligularone and (.+-.)-petasalbine
Easton et al. Regioselective functionalization of N-phthaloyl-substituted amino acid and peptide derivatives
Kuehne et al. Total syntheses of tubotaiwine and 19, 20-dihydro-20-epi-akuammicine
NO171974B (no) Fremgangsmaate for fremstilling av nafthalenderivater
McEwen et al. 1, 3-Dipolar addition reactions of Reissert compounds
Sasaki et al. Reactions of isoprenoids. XVIII. Reactions of chlorosulfonyl isocyanate with bicyclic monoterpene olefins. Novel isomerization of 1-chlorosulfonyl-2-azetidinone
Bobbitt et al. Synthesis of Isoquinolines. I. 1 Copyrine and Isoquinoline Systems Derived from 3-Cyano-4-methylpyridine2, 3
US4150042A (en) 6-Hydroxy-7-methoxy-5-benzofuran carboxaldehyde and 2,3-dihydro-7-methoxy-6-benzofuranol
Grove New metabolic products of Aspergillus flavus. Part II. Asperflavin, anhydroasperflavin, and 5, 7-dihydroxy-4-methylphthalide
Kempf et al. . beta.'Metalation of. alpha.,. beta.-unsaturated tertiary amides
Kupchan et al. Gnididione, a new furanosesquiterpene from Gnidia latifolia
Khatri et al. Isocyanide-metal exchange. The synthesis of masked acylcyanides
CA1202625A (fr) Procede de preparation de 5, 11-dishydro-11- [(4-methyl-1-piperazinyl) acethyl]-6h-pyrido [2,3-b] [1,4] benzodiazepine-6-ones
Anderson et al. Vinylogous carbinolamine tumor inhibitors. 14. 1, 3-dipolar cycloaddition reactions with tetrafluoroborate and trifluoromethanesulfonate salts of 1, 2-dihydro-and 1, 2, 3, 4-tetrahydroquinoline reissert compounds
US4021478A (en) Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
Potts et al. Synthesis of sempervirine
Lawson et al. Preparation and cycloaddition reactions of some αβ-unsaturated dithioesters
Zunnebeld et al. Total synthesis of 13-and 14-azaequilenines via heterocycloaddition
Dickens et al. Transition metal mediated synthesis of (±)-chuangxinmycin methyl ester
US4778892A (en) Certain 3-selena-7-aza-bicyclo[3.3.1]nonanes as antiarrhythmic agents