CA1045551A - Preparation for increasing the blood calcium level of animals - Google Patents
Preparation for increasing the blood calcium level of animalsInfo
- Publication number
- CA1045551A CA1045551A CA219,172A CA219172A CA1045551A CA 1045551 A CA1045551 A CA 1045551A CA 219172 A CA219172 A CA 219172A CA 1045551 A CA1045551 A CA 1045551A
- Authority
- CA
- Canada
- Prior art keywords
- gel
- forming polymer
- mixture
- calcium chloride
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 229910052791 calcium Inorganic materials 0.000 title claims description 31
- 239000011575 calcium Substances 0.000 title claims description 31
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 30
- 210000004369 blood Anatomy 0.000 title claims description 12
- 239000008280 blood Substances 0.000 title claims description 12
- 241001465754 Metazoa Species 0.000 title claims description 10
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 30
- 229920000642 polymer Polymers 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 29
- 239000001110 calcium chloride Substances 0.000 claims abstract description 27
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims description 25
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- QHFQAJHNDKBRBO-UHFFFAOYSA-L calcium chloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Ca+2] QHFQAJHNDKBRBO-UHFFFAOYSA-L 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 7
- 241000283690 Bos taurus Species 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 4
- 230000006735 deficit Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 101000635799 Homo sapiens Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Proteins 0.000 description 1
- 208000007542 Paresis Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102100030852 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Human genes 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 229940072020 calcium borogluconate Drugs 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- SSKRIDIHZLFJCG-UHFFFAOYSA-L calcium;2,3-dihydroxy-3-[2-hydroxy-5-(hydroxymethyl)-1,3,2-dioxaborolan-4-yl]propanoate Chemical compound [Ca+2].OCC1OB(O)OC1C(O)C(O)C([O-])=O.OCC1OB(O)OC1C(O)C(O)C([O-])=O SSKRIDIHZLFJCG-UHFFFAOYSA-L 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000004687 hexahydrates Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT114174A AT326406B (de) | 1974-02-13 | 1974-02-13 | Verfahren zur herstellung eines mittels zum heben des blutcalciumgehaltes bei tieren |
| AT561774A AT332161B (de) | 1974-07-08 | 1974-07-08 | Verfahren zur herstellung eines mittels zum heben des blutcalciumgehaltes bei tieren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1045551A true CA1045551A (en) | 1979-01-02 |
Family
ID=25595010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA219,172A Expired CA1045551A (en) | 1974-02-13 | 1975-01-31 | Preparation for increasing the blood calcium level of animals |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3996351A (https=) |
| CA (1) | CA1045551A (https=) |
| DE (1) | DE2505755A1 (https=) |
| FR (1) | FR2272682A1 (https=) |
| GB (1) | GB1469224A (https=) |
| NL (1) | NL7501601A (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451389A (en) * | 1980-05-22 | 1984-05-29 | Phillips Petroleum Company | Aqueous gels |
| US4321968A (en) * | 1980-05-22 | 1982-03-30 | Phillips Petroleum Company | Methods of using aqueous gels |
| DE3228231A1 (de) | 1982-07-28 | 1984-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Arzneimittel, calciummischsalze von polymeren, anionischen carbonsaeuren und/oder schwefelsaeureestern, verfahren zu ihrer herstellung und ihre verwendung |
| EP0449810B1 (en) * | 1988-12-23 | 1993-03-31 | Boehringer Ingelheim Agrovet A/S | Calcium chloride containing preparation for the prevention or the treatment of hypocalcemia in ruminants |
| US5395622A (en) * | 1988-12-23 | 1995-03-07 | Boehringer Ingelheim Agrovet A/S | Calcium chloride containing preparation for the prevention or the treatment of hypocalcemia in ruminants |
| CA2008330A1 (en) * | 1989-02-09 | 1990-08-09 | Francisco Cabrera | Calcium therapy treatment for milk fever |
| US5660859A (en) * | 1994-12-29 | 1997-08-26 | Mcneil-Ppc, Inc. | Gelling agent for polyethylene glycol |
| IT1312325B1 (it) * | 1999-05-25 | 2002-04-15 | M Soda Sa | Microgranulo per l'alimentazione animale, particolarmente idoneo perintegrare mangimi con sali di calcio. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3356570A (en) * | 1964-11-27 | 1967-12-05 | Trustees Of Barnes Hospital | Composition for treating shock |
| FR7932M (https=) * | 1968-09-30 | 1970-05-19 | ||
| US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US3608063A (en) * | 1969-08-15 | 1971-09-21 | Gilbert S Banker | Molecular drug entrapment process and compositions |
| US3640741A (en) * | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
-
1975
- 1975-01-30 US US05/545,419 patent/US3996351A/en not_active Expired - Lifetime
- 1975-01-31 CA CA219,172A patent/CA1045551A/en not_active Expired
- 1975-02-07 FR FR7503804A patent/FR2272682A1/fr active Pending
- 1975-02-11 NL NL7501601A patent/NL7501601A/xx not_active Application Discontinuation
- 1975-02-12 DE DE19752505755 patent/DE2505755A1/de not_active Withdrawn
- 1975-02-13 GB GB618275A patent/GB1469224A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1469224A (en) | 1977-04-06 |
| US3996351A (en) | 1976-12-07 |
| DE2505755A1 (de) | 1975-08-14 |
| NL7501601A (nl) | 1975-08-15 |
| FR2272682A1 (https=) | 1975-12-26 |
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