CA1013342A - Process for producing a.delta.4-3-keto-steroid-17-propiolactone and intermediates for such a lactone - Google Patents

Process for producing a.delta.4-3-keto-steroid-17-propiolactone and intermediates for such a lactone

Info

Publication number
CA1013342A
CA1013342A CA200,776A CA200776A CA1013342A CA 1013342 A CA1013342 A CA 1013342A CA 200776 A CA200776 A CA 200776A CA 1013342 A CA1013342 A CA 1013342A
Authority
CA
Canada
Prior art keywords
propiolactone
keto
lactone
steroid
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA200,776A
Other languages
English (en)
Other versions
CA200776S (en
Inventor
Rainer Philippson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732327448 external-priority patent/DE2327448C3/de
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of CA1013342A publication Critical patent/CA1013342A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
CA200,776A 1973-05-25 1974-05-24 Process for producing a.delta.4-3-keto-steroid-17-propiolactone and intermediates for such a lactone Expired CA1013342A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732327448 DE2327448C3 (de) 1973-05-25 Verfahren zur Herstellung von 17alpha-(3-Hydroxypropyl)-17beta-hydroxy-3-keto -4-a nd roste n

Publications (1)

Publication Number Publication Date
CA1013342A true CA1013342A (en) 1977-07-05

Family

ID=5882517

Family Applications (1)

Application Number Title Priority Date Filing Date
CA200,776A Expired CA1013342A (en) 1973-05-25 1974-05-24 Process for producing a.delta.4-3-keto-steroid-17-propiolactone and intermediates for such a lactone

Country Status (19)

Country Link
US (1) US3966714A (fr)
JP (1) JPS5821640B2 (fr)
AT (1) AT351179B (fr)
BE (1) BE815493A (fr)
CA (1) CA1013342A (fr)
CH (1) CH609357A5 (fr)
CS (1) CS169769B2 (fr)
DD (1) DD113353A5 (fr)
DK (1) DK131633C (fr)
ES (1) ES426419A1 (fr)
FR (1) FR2230630B1 (fr)
GB (1) GB1472300A (fr)
HU (1) HU166779B (fr)
IE (1) IE39279B1 (fr)
IL (1) IL44886A (fr)
NL (1) NL184221C (fr)
SE (1) SE401187B (fr)
SU (1) SU633486A3 (fr)
YU (1) YU36385B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH631462A5 (de) * 1976-03-05 1982-08-13 Schering Ag Verfahren zur herstellung von neuen steroiden der androstan- oder oestranreihe.
ES469510A1 (es) * 1977-05-16 1978-12-01 Schering Ag Procedimiento para la preparacion de 17beta hidroxi-4-an- drosten-3-onas.
DE3026783C2 (de) * 1980-07-11 1982-07-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
US4501695A (en) * 1983-05-16 1985-02-26 The Upjohn Company Spironalactone process
DE3414508A1 (de) * 1984-04-13 1985-10-24 Schering AG, 1000 Berlin und 4709 Bergkamen Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
CN104327149B (zh) * 2014-09-11 2017-01-11 浙江神洲药业有限公司 一种螺内酯中间体睾丸素内酯的合成方法
CN104327150B (zh) * 2014-09-11 2016-08-24 浙江神洲药业有限公司 一种螺内酯中间体坎利酮的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171543A (fr) * 1956-03-10 1959-01-27 Schering Ag Procédé d'éthinylation de 17-céto-stéroïdes
US3325484A (en) * 1963-11-15 1967-06-13 American Home Prod Process for preparing periplogenia and intermediates secured therein
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes
US3462426A (en) * 1967-10-30 1969-08-19 Searle & Co 3 - (3 - oxo - 11beta,13beta-dialkyl-17beta-hydroxygonen - 17alpha - yl) propionic acid gamma-lactones and intermediates
US3455909A (en) * 1968-05-29 1969-07-15 American Home Prod 3-desoxy steroidal-1,4-diene lactones and spiroethers
US3753979A (en) * 1971-12-06 1973-08-21 Merck & Co Inc Substituted 1,2alpha-methylene-6,7alpha-halomethylene-20-spirox-4-en-3-ones or 3-ols and acyl esters thereof

Also Published As

Publication number Publication date
CH609357A5 (fr) 1979-02-28
DK131633C (da) 1976-01-12
ES426419A1 (es) 1976-07-01
US3966714A (en) 1976-06-29
FR2230630B1 (fr) 1977-10-14
IE39279B1 (en) 1978-09-13
BE815493A (fr) 1974-11-25
HU166779B (fr) 1975-05-28
GB1472300A (en) 1977-05-04
FR2230630A1 (fr) 1974-12-20
JPS5821640B2 (ja) 1983-05-02
ATA420974A (de) 1978-12-15
JPS5030861A (fr) 1975-03-27
NL7406978A (fr) 1974-11-27
YU129274A (en) 1981-11-13
DE2327448A1 (de) 1974-12-12
AT351179B (de) 1979-07-10
IL44886A0 (en) 1974-09-10
NL184221C (nl) 1989-05-16
YU36385B (en) 1983-06-30
DE2327448B2 (de) 1976-04-29
SE401187B (sv) 1978-04-24
CS169769B2 (fr) 1976-07-29
DK262774A (fr) 1975-01-20
IE39279L (en) 1974-11-25
DD113353A5 (fr) 1975-06-05
AU6914874A (en) 1975-11-20
IL44886A (en) 1977-10-31
DK131633B (da) 1975-08-11
SU633486A3 (ru) 1978-11-15

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