CA1004220A - 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacetamido) desacetoxycephalosporanic acid dihydrate - Google Patents

7-(d-alpha-amino-1,4-cyclohexadien-1-ylacetamido) desacetoxycephalosporanic acid dihydrate

Info

Publication number
CA1004220A
CA1004220A CA169,770A CA169770A CA1004220A CA 1004220 A CA1004220 A CA 1004220A CA 169770 A CA169770 A CA 169770A CA 1004220 A CA1004220 A CA 1004220A
Authority
CA
Canada
Prior art keywords
ylacetamido
cyclohexadien
alpha
amino
acid dihydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA169,770A
Other languages
English (en)
Other versions
CA169770S (en
Inventor
Theodore M. Siewarga
Friedrich Dursch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1004220A publication Critical patent/CA1004220A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA169,770A 1972-06-01 1973-04-27 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacetamido) desacetoxycephalosporanic acid dihydrate Expired CA1004220A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00258767A US3819620A (en) 1972-06-01 1972-06-01 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacet-amido)desacetoxycephalosporanic acid dihydrate

Publications (1)

Publication Number Publication Date
CA1004220A true CA1004220A (en) 1977-01-25

Family

ID=22982041

Family Applications (1)

Application Number Title Priority Date Filing Date
CA169,770A Expired CA1004220A (en) 1972-06-01 1973-04-27 7-(d-alpha-amino-1,4-cyclohexadien-1-ylacetamido) desacetoxycephalosporanic acid dihydrate

Country Status (30)

Country Link
US (1) US3819620A (ja)
JP (1) JPS5544754B2 (ja)
KR (1) KR820001606B1 (ja)
AR (1) AR196669A1 (ja)
AT (1) AT322740B (ja)
AU (1) AU475833B2 (ja)
BE (1) BE800373A (ja)
BR (1) BR7303959D0 (ja)
CA (1) CA1004220A (ja)
CH (1) CH582185A5 (ja)
CS (1) CS178428B2 (ja)
DD (1) DD106181A5 (ja)
DE (1) DE2326880C2 (ja)
EG (1) EG11139A (ja)
ES (1) ES415420A1 (ja)
FI (1) FI57952C (ja)
FR (1) FR2186234B1 (ja)
GB (1) GB1426266A (ja)
HU (1) HU167052B (ja)
IE (1) IE38750B1 (ja)
IL (1) IL42243A (ja)
IN (1) IN138787B (ja)
IT (1) IT1068202B (ja)
NL (1) NL176267C (ja)
NO (1) NO144849C (ja)
PL (1) PL87262B1 (ja)
RO (2) RO68286A (ja)
SE (1) SE409714B (ja)
SU (1) SU465793A3 (ja)
ZA (1) ZA732889B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5725557B2 (ja) * 1972-11-17 1982-05-29
CH619233A5 (ja) * 1975-07-31 1980-09-15 Ciba Geigy Ag
US4054738A (en) * 1975-12-22 1977-10-18 Eli Lilly And Company Sodium cefamandole crystalline forms
US4946838A (en) * 1981-07-13 1990-08-07 E. R. Squibb & Sons, Inc. Crystalline anhydrous aztreonam
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
DK0433428T3 (da) * 1989-07-10 1994-12-05 Chemferm Vof Hidtil ukendt stabil form af cephradin, fremgangsmåde til fremstilling deraf og mellemprodukter anvendt derved
US5278157A (en) * 1989-07-10 1994-01-11 Gema, S.A. Stable cephradine hydrate
IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
CN1326860C (zh) * 2002-08-06 2007-07-18 北京化工大学 头孢拉定晶体以及制备头孢拉定的方法
WO2005003367A2 (en) * 2003-07-03 2005-01-13 Dsm Ip Assets B.V. Process for the preparation of cephradine
CN104688713A (zh) * 2015-03-20 2015-06-10 江苏亚邦强生药业有限公司 一种头孢拉定胶囊剂及其制备方法
CN112206217A (zh) * 2020-10-21 2021-01-12 迪沙药业集团有限公司 一种头孢拉定药物组合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485819A (en) * 1968-07-02 1969-12-23 Squibb & Sons Inc Alpha-amino-cyclohexadienylalkylene-penicillins and cephalosporins

Also Published As

Publication number Publication date
BR7303959D0 (pt) 1974-08-29
FI57952C (fi) 1981-09-07
AR196669A1 (es) 1974-02-12
NO144849B (no) 1981-08-17
IN138787B (ja) 1976-03-27
IL42243A0 (en) 1973-07-30
PL87262B1 (ja) 1976-06-30
BE800373A (fr) 1973-12-03
SE409714B (sv) 1979-09-03
EG11139A (en) 1978-03-29
CS178428B2 (ja) 1977-09-15
RO68286A (ro) 1980-12-30
NL176267C (nl) 1985-03-18
NO144849C (no) 1981-11-25
JPS4941520A (ja) 1974-04-18
ES415420A1 (es) 1976-02-16
FR2186234B1 (ja) 1976-10-22
AU475833B2 (en) 1976-09-02
AT322740B (de) 1975-06-10
US3819620A (en) 1974-06-25
CH582185A5 (ja) 1976-11-30
DE2326880C2 (de) 1982-04-15
IE38750B1 (en) 1978-05-24
DD106181A5 (ja) 1974-06-05
GB1426266A (en) 1976-02-25
RO63443A (fr) 1978-07-15
IE38750L (en) 1973-12-01
NL7307321A (ja) 1973-12-04
JPS5544754B2 (ja) 1980-11-13
KR820001606B1 (ko) 1982-09-08
AU5507473A (en) 1974-11-07
HU167052B (ja) 1975-07-28
IT1068202B (it) 1985-03-21
IL42243A (en) 1975-10-15
FR2186234A1 (ja) 1974-01-11
ZA732889B (en) 1974-04-24
DE2326880A1 (de) 1973-12-20
SU465793A3 (ru) 1975-03-30
FI57952B (fi) 1980-07-31

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