BRPI9912125B8 - benzenossulfoniluréias e - tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas - Google Patents

benzenossulfoniluréias e - tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas

Info

Publication number
BRPI9912125B8
BRPI9912125B8 BRPI9912125A BR9912125A BRPI9912125B8 BR PI9912125 B8 BRPI9912125 B8 BR PI9912125B8 BR PI9912125 A BRPI9912125 A BR PI9912125A BR 9912125 A BR9912125 A BR 9912125A BR PI9912125 B8 BRPI9912125 B8 BR PI9912125B8
Authority
BR
Brazil
Prior art keywords
processes
preparation
pharmaceutical preparations
preparations containing
benzenesulfonylureas
Prior art date
Application number
BRPI9912125A
Other languages
English (en)
Other versions
BR9912125B1 (pt
BR9912125A (pt
Inventor
Christian Englert Heinrich
Goegelein Heinz
Heitsch Holger
Original Assignee
Aventis Pharma Deustschland Gmbh
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deustschland Gmbh, Sanofi Aventis Deutschland filed Critical Aventis Pharma Deustschland Gmbh
Publication of BR9912125A publication Critical patent/BR9912125A/pt
Publication of BR9912125B1 publication Critical patent/BR9912125B1/pt
Publication of BRPI9912125B8 publication Critical patent/BRPI9912125B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

patente de invenção: <b>"benzenossulfoniluréias e -tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas"<d>. a presente invenção refere-se a novas benzenossulfoniluréias e -tiouréias 2,5-substituídas da fórmula (i), na qual r(1), r(2), r(3), r(4), x e y têm os significados indicados nas reivindicações, que são valiosas substâncias ativas medicamentosas. os compostos da fórmula (i) têm um efeito inibidor sobre canais de potássio sensitivos ao atp e prestam-se por exemplo, para o tratamento de distúrbios do sistema circulatório do coração, especialmente para o tratamento de arritmias, para evitar a morte súbita do coração ou para influenciar uma contratilidade reduzida do coração. a invenção refere-se além disso, a processos para a preparação dos compostos da fórmula (i), seu emprego e preparados farmacêuticos contendo os mesmos.
BRPI9912125A 1998-07-16 1999-07-03 benzenossulfoniluréias e - tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas BRPI9912125B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19832009A DE19832009A1 (de) 1998-07-16 1998-07-16 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
PCT/EP1999/004643 WO2000003978A2 (de) 1998-07-16 1999-07-03 2,5-substituierte benzolsulfonylharnstoffe und -thioharnstoffe, v,rfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate

Publications (3)

Publication Number Publication Date
BR9912125A BR9912125A (pt) 2001-04-10
BR9912125B1 BR9912125B1 (pt) 2013-11-05
BRPI9912125B8 true BRPI9912125B8 (pt) 2017-03-14

Family

ID=7874296

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9912125A BRPI9912125B8 (pt) 1998-07-16 1999-07-03 benzenossulfoniluréias e - tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas

Country Status (23)

Country Link
US (1) US6410573B1 (pt)
EP (1) EP1100775B1 (pt)
JP (1) JP4486254B2 (pt)
KR (1) KR100979894B1 (pt)
CN (1) CN1330632C (pt)
AR (1) AR029305A1 (pt)
AT (1) ATE256657T1 (pt)
AU (1) AU763031B2 (pt)
BR (1) BRPI9912125B8 (pt)
CA (1) CA2337397C (pt)
CZ (1) CZ300828B6 (pt)
DE (2) DE19832009A1 (pt)
DK (1) DK1100775T3 (pt)
ES (1) ES2211126T3 (pt)
HK (1) HK1038914B (pt)
HU (1) HU227423B1 (pt)
ID (1) ID27025A (pt)
PL (1) PL194299B1 (pt)
PT (1) PT1100775E (pt)
RU (1) RU2235720C2 (pt)
TR (1) TR200100083T2 (pt)
WO (1) WO2000003978A2 (pt)
ZA (1) ZA200007691B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19923086A1 (de) 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
DE102004061017A1 (de) * 2004-12-18 2006-06-22 Sanofi-Aventis Deutschland Gmbh Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DK2164825T3 (da) * 2007-06-05 2014-07-14 Sanofi Sa Di(hetero)arylcyclohexanderivater, deres fremstilling, deres anvendelse og terapeutiske præparater, der omfatter disse
US8299123B2 (en) 2007-10-19 2012-10-30 Boehringer Ingelheim International Gmbh CCR10 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE146775T1 (de) 1993-02-23 1997-01-15 Hoechst Ag Substituierte benzolsulfonylharnstoffe und - thioharnstoffe- verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika
DE4341655A1 (de) 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
US5631275A (en) 1993-12-30 1997-05-20 Hoechst Aktiengesellschaft Substituted benzenesulfonylureas and -thioureas, preparation processes and possible uses of pharmaceutical preparations based on these compounds
DE4344957A1 (de) 1993-12-30 1995-07-06 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Herstellungsverfahren und Verwendungsmöglichkeiten pharmazeutischer Präparate auf Basis dieser Verbindungen
DE19504379A1 (de) 1995-02-10 1996-08-14 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
DE19505397A1 (de) 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
HU226462B1 (en) 1995-02-17 2008-12-29 Hoechst Ag Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
ZA961314B (en) 1995-02-21 1996-08-27 Hoechst Ag Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
CZ20002758A3 (cs) * 1999-01-27 2000-12-13 Icagen, Inc. Inhibitory draslíkových kanálů

Also Published As

Publication number Publication date
HUP0105111A3 (en) 2003-02-28
DK1100775T3 (da) 2004-04-05
CN1314884A (zh) 2001-09-26
CZ2001169A3 (en) 2001-05-16
HK1038914B (zh) 2008-01-25
HK1038914A1 (en) 2002-04-04
CA2337397C (en) 2009-01-13
BR9912125B1 (pt) 2013-11-05
JP4486254B2 (ja) 2010-06-23
BR9912125A (pt) 2001-04-10
ATE256657T1 (de) 2004-01-15
KR100979894B1 (ko) 2010-09-06
CA2337397A1 (en) 2000-01-27
PL345710A1 (en) 2002-01-02
JP2002520387A (ja) 2002-07-09
EP1100775A2 (de) 2001-05-23
HUP0105111A1 (hu) 2002-05-29
ES2211126T3 (es) 2004-07-01
DE59908123D1 (de) 2004-01-29
DE19832009A1 (de) 2000-01-20
PT1100775E (pt) 2004-05-31
HU227423B1 (en) 2011-05-30
AU5030799A (en) 2000-02-07
KR20010074720A (ko) 2001-08-09
TR200100083T2 (tr) 2001-06-21
AU763031B2 (en) 2003-07-10
PL194299B1 (pl) 2007-05-31
WO2000003978A3 (de) 2000-09-14
US6410573B1 (en) 2002-06-25
ZA200007691B (en) 2002-01-21
EP1100775B1 (de) 2003-12-17
AR029305A1 (es) 2003-06-25
ID27025A (id) 2001-02-22
CZ300828B6 (cs) 2009-08-19
WO2000003978A2 (de) 2000-01-27
RU2235720C2 (ru) 2004-09-10
CN1330632C (zh) 2007-08-08

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