BRPI9710363B1 - partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso. - Google Patents
partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso.Info
- Publication number
- BRPI9710363B1 BRPI9710363B1 BRPI9710363-2A BRPI9710363A BRPI9710363B1 BR PI9710363 B1 BRPI9710363 B1 BR PI9710363B1 BR PI9710363 A BRPI9710363 A BR PI9710363A BR PI9710363 B1 BRPI9710363 B1 BR PI9710363B1
- Authority
- BR
- Brazil
- Prior art keywords
- rsv
- respiratory syncytial
- syncytial virus
- recombinant respiratory
- attenuated
- Prior art date
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 12
- 230000002238 attenuated effect Effects 0.000 title abstract 4
- 208000015181 infectious disease Diseases 0.000 title abstract 4
- 230000002458 infectious effect Effects 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 239000013604 expression vector Substances 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 230000035772 mutation Effects 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2177396P | 1996-07-15 | 1996-07-15 | |
US4614197P | 1997-05-09 | 1997-05-09 | |
US4763497P | 1997-05-23 | 1997-05-23 | |
PCT/US1997/012269 WO1998002530A1 (en) | 1996-07-15 | 1997-07-15 | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI9710363A BRPI9710363A (pt) | 2000-01-11 |
BRPI9710363B1 true BRPI9710363B1 (pt) | 2011-11-16 |
BRPI9710363B8 BRPI9710363B8 (pt) | 2021-07-06 |
Family
ID=27361727
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9710363-2A BR9710363A (pt) | 1996-07-15 | 1997-07-15 | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
BRPI9710363 BRPI9710363B8 (pt) | 1996-07-15 | 1997-07-15 | partìcula de vìrus sincicial respirátorio recombinante (rsv) infeccioso atenuado, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante (rsv), vetor de expressão, e, método de produção de um vìrus sincicial respiratório recombinante (rsv) infeccioso. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9710363-2A BR9710363A (pt) | 1996-07-15 | 1997-07-15 | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
Country Status (12)
Country | Link |
---|---|
US (2) | US5993824A (pt) |
EP (2) | EP0912724B1 (pt) |
JP (2) | JP4413999B2 (pt) |
KR (2) | KR100658491B1 (pt) |
CN (1) | CN101012454B (pt) |
AT (1) | ATE451451T1 (pt) |
AU (1) | AU3799797A (pt) |
BR (2) | BR9710363A (pt) |
CA (1) | CA2257823A1 (pt) |
DE (1) | DE69739689D1 (pt) |
ES (1) | ES2345643T3 (pt) |
WO (1) | WO1998002530A1 (pt) |
Families Citing this family (129)
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US7465574B2 (en) * | 1994-09-30 | 2008-12-16 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
US20030054505A1 (en) * | 1997-09-26 | 2003-03-20 | Hong Jin | Recombinant rsv expression systems and vaccines |
US20050287540A1 (en) * | 1995-09-27 | 2005-12-29 | Murphy Brian R | Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences |
US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
US7846455B2 (en) | 1996-07-15 | 2010-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated chimeric respiratory syncytial virus |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
BR9710363A (pt) | 1996-07-15 | 2000-01-11 | Us Gov Health & Human Serv | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
WO1998050529A1 (en) * | 1997-05-02 | 1998-11-12 | The Uab Research Foundation | Attenuation of negative stranded rna viruses by rearrangement of their genes and uses thereof |
US6596529B1 (en) * | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US6410023B1 (en) | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
US7192593B2 (en) * | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7314631B1 (en) | 1997-05-23 | 2008-01-01 | The United States Of America As Represented By The Department Of Health And Human Services | Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7250171B1 (en) | 1997-05-23 | 2007-07-31 | United States Of America As Represented By The Dept. Of Health & Human Services | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein |
CA2238659C (en) * | 1997-05-26 | 2010-12-14 | Akzo Nobel N.V. | Recombinant birnavirus vaccine |
FR2764903A1 (fr) * | 1997-06-23 | 1998-12-24 | Pasteur Institut | Detection des infections par des paramyxovirus (virus respiratoire syncitial et virus parainfluenza) utilisant des polynucleotides codant de la proteine l |
US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
US7662397B2 (en) * | 1997-07-15 | 2010-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
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US6908618B2 (en) | 1997-11-10 | 2005-06-21 | University Of Maryland | Production of novel bovine respiratory syncytial viruses from cDNAs |
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US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
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-
1997
- 1997-07-15 BR BR9710363-2A patent/BR9710363A/pt not_active IP Right Cessation
- 1997-07-15 US US08/892,403 patent/US5993824A/en not_active Expired - Lifetime
- 1997-07-15 JP JP50623598A patent/JP4413999B2/ja not_active Expired - Fee Related
- 1997-07-15 BR BRPI9710363 patent/BRPI9710363B8/pt unknown
- 1997-07-15 CN CN2006101215400A patent/CN101012454B/zh not_active Expired - Fee Related
- 1997-07-15 EP EP97934948A patent/EP0912724B1/en not_active Expired - Lifetime
- 1997-07-15 ES ES97934948T patent/ES2345643T3/es not_active Expired - Lifetime
- 1997-07-15 EP EP09157028A patent/EP2112220A3/en not_active Withdrawn
- 1997-07-15 CA CA002257823A patent/CA2257823A1/en not_active Abandoned
- 1997-07-15 KR KR1019997000286A patent/KR100658491B1/ko not_active IP Right Cessation
- 1997-07-15 AT AT97934948T patent/ATE451451T1/de not_active IP Right Cessation
- 1997-07-15 KR KR1020057024993A patent/KR100894670B1/ko not_active IP Right Cessation
- 1997-07-15 DE DE69739689T patent/DE69739689D1/de not_active Expired - Lifetime
- 1997-07-15 WO PCT/US1997/012269 patent/WO1998002530A1/en not_active Application Discontinuation
- 1997-07-15 AU AU37997/97A patent/AU3799797A/en not_active Abandoned
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2004
- 2004-09-02 US US10/934,003 patent/US7709007B2/en not_active Expired - Fee Related
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- 2008-07-15 JP JP2008184327A patent/JP2008283984A/ja active Pending
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EP0912724A1 (en) | 1999-05-06 |
EP2112220A2 (en) | 2009-10-28 |
CA2257823A1 (en) | 1998-01-22 |
US7709007B2 (en) | 2010-05-04 |
ES2345643T3 (es) | 2010-09-28 |
CN101012454A (zh) | 2007-08-08 |
BRPI9710363B8 (pt) | 2021-07-06 |
KR100658491B1 (ko) | 2006-12-18 |
BR9710363A (pt) | 2000-01-11 |
AU3799797A (en) | 1998-02-09 |
US20060159703A1 (en) | 2006-07-20 |
ATE451451T1 (de) | 2009-12-15 |
KR100894670B1 (ko) | 2009-04-22 |
BRPI9710363A (pt) | 2000-01-11 |
EP0912724B1 (en) | 2009-12-09 |
JP2008283984A (ja) | 2008-11-27 |
KR20000023802A (ko) | 2000-04-25 |
WO1998002530A1 (en) | 1998-01-22 |
DE69739689D1 (de) | 2010-01-21 |
EP2112220A3 (en) | 2010-01-06 |
JP4413999B2 (ja) | 2010-02-10 |
US5993824A (en) | 1999-11-30 |
KR20060015658A (ko) | 2006-02-17 |
CN101012454B (zh) | 2011-11-16 |
JP2002511731A (ja) | 2002-04-16 |
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