BRPI9609235B8 - peptídeo. - Google Patents
peptídeo.Info
- Publication number
- BRPI9609235B8 BRPI9609235B8 BRPI9609235A BR9609235A BRPI9609235B8 BR PI9609235 B8 BRPI9609235 B8 BR PI9609235B8 BR PI9609235 A BRPI9609235 A BR PI9609235A BR 9609235 A BR9609235 A BR 9609235A BR PI9609235 B8 BRPI9609235 B8 BR PI9609235B8
- Authority
- BR
- Brazil
- Prior art keywords
- leu
- trp
- pro
- tyr
- phe
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 4
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 2
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960002684 aminocaproic acid Drugs 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 2
- 230000004957 immunoregulator effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"petídeos e processos para sua obtenção". a invenção diz respeito à medicina, especificamente a processos de obtenção de substâncias biologicamente ativas com propriedades imuno-regulatórias, e pode ser usada na medicina, na ciência veterinária e na bioquímica experimental. o problema abrangido pela invenção é o de se produzir um novo peptídeo biologicamente ativo sintético com propriedades imuno-regulatórias, de fórmulas x-a-d-trp-y, em que a é d-glu, id-glu; x é h ou gly, ala, leu, ile, val, nval, pro, tyr, phe, d-ala, d-leu, d-ile, d-val, d-bval, d-pro, d-pro, d-tyr, d-phe, d-trp, ácido y- aminobutírico, ácido <sym>-aminocapróico; y é gly, ala, leu, ile, val, nval, pro, tyr, phe, trp, d-ala, d-leu, d-ile, d-val, d-nval, d-pro, d-tyr, d-phe, d-trp, ácido y-aminobutírico, ácido <sym>-aminocapróico, -oh ou amida substituída (c~ 1~-c~ 3~). o processo de produção do peptídeo envolve a síntese de peptídeos que contêm glutamila, em solução, mediante a cisão de um anidrido interno do ácido glutâmico (d ou l) tribuloxicarbonílico com o apropriado sal de k de d-trp-y. isto é seguido por separação 11500/cromatográfica de isômeros <244> e y. síntese adicional foi efetuada estruturado-se uma cadeia de peptídeos utilizando-se ésteres ativados de ácidos amino tributiloxicarbonílicos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU95108559A RU2107692C1 (ru) | 1995-06-07 | 1995-06-07 | Пептид и способ его получения |
| PCT/RU1996/000116 WO1996040740A1 (en) | 1995-06-07 | 1996-05-06 | Peptide and method of obtaining it |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9609235A BR9609235A (pt) | 1999-12-21 |
| BR9609235B1 BR9609235B1 (pt) | 2009-01-13 |
| BRPI9609235B8 true BRPI9609235B8 (pt) | 2016-09-27 |
Family
ID=20168146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9609235A BRPI9609235B8 (pt) | 1995-06-07 | 1996-05-06 | peptídeo. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5736519A (pt) |
| EP (1) | EP0832900B1 (pt) |
| JP (1) | JP4082522B2 (pt) |
| CN (1) | CN1154653C (pt) |
| AT (1) | ATE260933T1 (pt) |
| AU (1) | AU724781B2 (pt) |
| BR (1) | BRPI9609235B8 (pt) |
| CA (1) | CA2222296C (pt) |
| CZ (1) | CZ287816B6 (pt) |
| DE (1) | DE69631762T2 (pt) |
| DK (1) | DK0832900T3 (pt) |
| ES (1) | ES2217311T3 (pt) |
| HK (1) | HK1014965A1 (pt) |
| HU (1) | HU228461B1 (pt) |
| LT (1) | LT4476B (pt) |
| LV (1) | LV12074B (pt) |
| PT (1) | PT832900E (pt) |
| RU (1) | RU2107692C1 (pt) |
| SK (1) | SK281825B6 (pt) |
| UA (1) | UA48974C2 (pt) |
| WO (1) | WO1996040740A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2107691C1 (ru) * | 1995-03-02 | 1998-03-27 | Дейгин Владислав Исакович | Пептид и способ его получения |
| US5916878A (en) * | 1995-11-28 | 1999-06-29 | Edward T. Wei | γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith |
| US6159940A (en) * | 1996-02-28 | 2000-12-12 | Immunotech Developments Inc. | Method for modulating hemopoiesis |
| DE19712633A1 (de) * | 1997-03-26 | 1998-10-08 | Laves Arzneimittel | Verwendung von gamma-Aminobuttersäure als Interleukinbildungsstimulans |
| IL145926A0 (en) | 2001-10-15 | 2002-07-25 | Mor Research Applic Ltd | Peptide epitopes of mimotopes useful in immunomodulation |
| IL155136A0 (en) | 2003-02-10 | 2003-10-31 | Enzymotec Ltd | A composition for reducing blood cholesterol and triglycerides |
| US20060233863A1 (en) | 2003-02-10 | 2006-10-19 | Enzymotec Ltd. | Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy |
| EP1613340B1 (en) * | 2003-03-28 | 2010-05-12 | SciClone Pharmaceuticals, Inc. | Treatment of aspergillus infections with thymosin alpha 1 |
| CN101035594B (zh) * | 2004-08-09 | 2013-10-23 | 酶学技术有限公司 | 用于糖尿病患者的食品 |
| JP5118965B2 (ja) | 2004-08-10 | 2013-01-16 | エンジモテック リミテッド | 植物成分を必要とする治療方法 |
| EP1919868B1 (en) * | 2005-03-18 | 2015-10-21 | Centre National De La Recherche Scientifique | New hybrid oligomers. their preparation process and pharmaceutical compositions containing them |
| CA2604133C (en) * | 2005-04-07 | 2015-12-01 | Centre National De La Recherche Scientifique | Compounds useful as modulators of the proteasome activity |
| EP1896500A4 (en) * | 2005-06-28 | 2010-08-11 | Yeda Res & Dev | GLIOMEDIN, FRAGMENTE AND METHOD OF ITS APPLICATION |
| CA2569204A1 (en) * | 2006-11-28 | 2008-05-28 | Apotex Technologies Inc. | Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan |
| CA2571645A1 (en) | 2006-12-19 | 2008-06-19 | Apotex Technologies Inc. | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture |
| UA96980C2 (ru) | 2007-02-13 | 2011-12-26 | Сайклон Фармасютикалс, Инк. | Способ уменьшения степени ухудшения состояния, поражения или повреждения слизистой оболочки |
| CA2579119C (en) | 2007-02-16 | 2013-03-05 | Apotex Technologies Inc. | Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan |
| WO2008142693A2 (en) * | 2007-05-22 | 2008-11-27 | Yeda Research And Development Co. Ltd. | Regulation of myelination by nectin-like (necl) molecules |
| CA2831427A1 (en) * | 2011-03-31 | 2012-10-04 | Apotex Technologies Inc. | Prodrugs of d-isoglutamyl-[d/l]-tryptophan |
| CN103502215A (zh) * | 2011-03-31 | 2014-01-08 | 阿普泰克斯科技公司 | D-γ-谷氨酰基-D-色氨酸和D-γ-谷氨酰基-L-色氨酸的前药 |
| CN102417474B (zh) * | 2011-09-26 | 2014-07-02 | 深圳翰宇药业股份有限公司 | D-异谷氨酰基-d-色氨酸制备的新方法 |
| RU2634258C1 (ru) * | 2016-11-08 | 2017-10-24 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Наполнитель для капсульного ингалятора |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3832337A (en) * | 1970-07-28 | 1974-08-27 | Squibb & Sons Inc | Peptide enzyme inhibitors |
| GB1526367A (en) * | 1976-10-12 | 1978-09-27 | Ici Ltd | Polypeptide |
| HU184481B (en) * | 1981-10-02 | 1984-08-28 | Richter Gedeon Vegyeszet | Process for producing tripeptides for diminishing appetite |
| JPS5921656A (ja) * | 1982-07-28 | 1984-02-03 | Takeda Chem Ind Ltd | ポリペプチド誘導体 |
| CH659586A5 (de) | 1985-07-02 | 1987-02-13 | Le G Ped I | Arzneimittel aus dem thymus und verfahren zu dessen herstellung. |
| CA1286989C (en) | 1985-12-26 | 1991-07-30 | A. Arthur Gottlieb | Immunoamplifiers and related compositions |
| IT1216908B (it) | 1987-03-19 | 1990-03-14 | Eniricerche Spa | Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. |
| WO1989006134A1 (en) * | 1987-12-30 | 1989-07-13 | Vsesojuzny Kardiologichesky Nauchny Tsentr Akademi | Pharmaceutical preparation for treating immunodeficiency conditions |
| US5021551A (en) | 1989-01-18 | 1991-06-04 | Washington University | Method of enhancing peptide immunogenicity |
| IT1230733B (it) | 1989-06-30 | 1991-10-29 | Eniricerche Spa | Analoghi della timopentina retro invertita a tutti i legami, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche. |
| WO1995003067A1 (en) * | 1993-07-21 | 1995-02-02 | Khavinson Vladimir Khatskelevi | Pharmaceutical with immunomodulating activity |
-
1995
- 1995-06-07 RU RU95108559A patent/RU2107692C1/ru active
-
1996
- 1996-05-06 PT PT96915261T patent/PT832900E/pt unknown
- 1996-05-06 DK DK96915261T patent/DK0832900T3/da active
- 1996-05-06 CN CNB961951532A patent/CN1154653C/zh not_active Expired - Fee Related
- 1996-05-06 WO PCT/RU1996/000116 patent/WO1996040740A1/ru active IP Right Grant
- 1996-05-06 DE DE69631762T patent/DE69631762T2/de not_active Expired - Lifetime
- 1996-05-06 SK SK1669-97A patent/SK281825B6/sk not_active IP Right Cessation
- 1996-05-06 AT AT96915261T patent/ATE260933T1/de active
- 1996-05-06 AU AU57076/96A patent/AU724781B2/en not_active Ceased
- 1996-05-06 HU HU9801990A patent/HU228461B1/hu not_active IP Right Cessation
- 1996-05-06 CZ CZ19973905A patent/CZ287816B6/cs not_active IP Right Cessation
- 1996-05-06 CA CA002222296A patent/CA2222296C/en not_active Expired - Fee Related
- 1996-05-06 BR BRPI9609235A patent/BRPI9609235B8/pt not_active IP Right Cessation
- 1996-05-06 ES ES96915261T patent/ES2217311T3/es not_active Expired - Lifetime
- 1996-05-06 UA UA98010039A patent/UA48974C2/uk unknown
- 1996-05-06 JP JP50033197A patent/JP4082522B2/ja not_active Expired - Fee Related
- 1996-05-06 EP EP96915261A patent/EP0832900B1/en not_active Expired - Lifetime
- 1996-06-07 US US08/657,888 patent/US5736519A/en not_active Expired - Lifetime
-
1997
- 1997-12-19 LV LVP-97-266A patent/LV12074B/lv unknown
-
1998
- 1998-01-07 LT LT98-004A patent/LT4476B/lt not_active IP Right Cessation
-
1999
- 1999-01-14 HK HK99100197A patent/HK1014965A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2217311T3 (es) | 2004-11-01 |
| EP0832900B1 (en) | 2004-03-03 |
| JP4082522B2 (ja) | 2008-04-30 |
| SK166997A3 (en) | 1998-04-08 |
| HUP9801990A3 (en) | 1999-06-28 |
| LT98004A (en) | 1998-10-26 |
| LV12074A (lv) | 1998-06-20 |
| EP0832900A4 (en) | 1999-10-06 |
| HU228461B1 (en) | 2013-03-28 |
| AU724781B2 (en) | 2000-09-28 |
| CZ390597A3 (cs) | 1998-08-12 |
| CN1154653C (zh) | 2004-06-23 |
| CZ287816B6 (en) | 2001-02-14 |
| DE69631762T2 (de) | 2005-03-10 |
| CA2222296A1 (en) | 1996-12-19 |
| CN1189837A (zh) | 1998-08-05 |
| HUP9801990A2 (hu) | 1999-02-01 |
| JPH11513016A (ja) | 1999-11-09 |
| HK1014965A1 (en) | 1999-10-08 |
| SK281825B6 (sk) | 2001-08-06 |
| WO1996040740A1 (en) | 1996-12-19 |
| BR9609235B1 (pt) | 2009-01-13 |
| LV12074B (lv) | 1998-08-20 |
| CA2222296C (en) | 2001-10-09 |
| US5736519A (en) | 1998-04-07 |
| AU5707696A (en) | 1996-12-30 |
| ATE260933T1 (de) | 2004-03-15 |
| LT4476B (lt) | 1999-03-25 |
| DK0832900T3 (da) | 2004-06-21 |
| BR9609235A (pt) | 1999-12-21 |
| DE69631762D1 (de) | 2004-04-08 |
| RU2107692C1 (ru) | 1998-03-27 |
| UA48974C2 (uk) | 2002-09-16 |
| PT832900E (pt) | 2004-07-30 |
| EP0832900A1 (en) | 1998-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI9609235B8 (pt) | peptídeo. | |
| McIntosh et al. | Gamma-carboxyglutamate in a neuroactive toxin. | |
| Vigneaud et al. | The synthesis of an octapeptide amide with the hormonal activity of oxytocin | |
| Loukas et al. | Opioid activities and structures of. alpha.-casein-derived exorphins | |
| Chorev et al. | A dozen years of retro-inverso peptidomimetics | |
| Rudinger | The design of peptide hormone analogs | |
| Ressler et al. | Identification of Asparaginyl and Glutaminyl Residues in endo Position in Peptides by Dehydration-Reduction1 | |
| Atherton et al. | Peptide synthesis. Part 7. Solid-phase synthesis of conotoxin G1 | |
| Vigneaud et al. | Enzymatic cleavage of glycinamide from vasopressin and a proposed structure for this pressor-antidiuretic hormone of the posterior pituitary | |
| RU2223970C2 (ru) | Лечение ожирения | |
| RU95108559A (ru) | Пептид и способ его получения | |
| BR9607901A (pt) | Peptìdeo e processo de obtenção do mesmo | |
| Hu et al. | Protection of 3, 4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis | |
| RU94024278A (ru) | Пептид и способ его получения | |
| PT779076E (pt) | Peptidos, um metodo para a sua obtencao e um composto farmaceutico om base nestes | |
| Carpino et al. | Dramatically enhanced N→ O acyl migration during the trifluoroacetic acid-based deprotection step in solid phase peptide synthesis | |
| US20180215784A1 (en) | Method for preparation of n-acyl peptides, polypeptides and proteins | |
| Sasaki et al. | On the degradation of dermorphin and D-Arg2-dermorphin analogs by a soluble rat brain extract | |
| RU2006111491A (ru) | Новые противоопухолевые соединения | |
| Crumpton et al. | The C-terminal antigenic site of sperm-whale myoglobin: the immunological activities of synthetic peptides related to the C-terminus of myoglobin. | |
| Woolley et al. | Strepogenin activity of synthetic peptides related to oxytocin | |
| Cheung et al. | N-Methylamino acids in peptide synthesis. VI. A method for determining the enantiomeric purity of N-methylamino acids and their derivatives by ion-exchange chromatography as their C-terminal lysyl dipeptides | |
| Morley et al. | MPF analogue with high stability to proteolysis | |
| Papkoff et al. | Hormone structure and biological activity: Biochemical studies of three pituitary hormones | |
| KR960706503A (ko) | CXC 인터크린 분자의 펩타이드 억제제(Peptide inhibitors of CXC intercrine molecules) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TE | Change of address | ||
| PC | Transfer |
Free format text: IMMUNOTECH DEVELOPMENTS INC. (CA) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, INDEFIRO O PRESENTE PEDIDO, TENDO POR BASE OS ARTIGOS 24 E 25 DA LPI 9279DE 14/05/1996. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/01/2009, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI-52400.061594/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132351-11.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: GLAXO GROUP LIMITED, GLAXO WELLCOME INC, IMMUNOTECH DEVELOPMENTS INC, IVAX INTERNACIONAL GMBH. |
|
| B19A | Notification of judicial decision: notification of judicial decision |
Free format text: INPI-52400.061594/2013- SECAO JUDICIARIA DO RIO DE JANEIRO 9A VARA FEDERAL PROCESSO NO 0132351-11.2013.4.02.5101 AUTOR: INPI INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL REU: GLAXO GROUP LIMITED, GLAXO WELLCOME INC DECISAO: ISTO POSTO, NOS MOLDES DO ART.487, I DO CPC, JULGO PROCEDENTE O PEDIDO PARA RETIFICAR O PRAZO DE VIGENCIA DA PATENTE MAILBOX NO PI 9609235-1, O QUAL PASSARA A TER PRAZO DE VIGENCIA ATE SER A VIGER ATE 06/05/2016, DEVENDO O INPI REALIZAR AS ANOTACOES ADMINISTRATIVAS CABIVEIS E AS RESPECTIVAS PUBLICACOES NA REVISTA DA PROPRIEDADE INDUSTRIAL. QUANTO AOS DEMAIS PEDIDOS, FICA EXTINTO O PROCESSO SEM RESOLUCAO DO MERITO, NOS TERMOS DO ART. 485 VI DO CPC. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A RPI 1984 DE 13/01/2009, POR DETERMINACAO JUDICIAL DA 9A VARA FEDERAL DO RIO DE JANEIRO,PROCESSO NO 0132351-11.2013.4.02.5101 - INPI 52400.061594/2013. QUANTO AO PRAZO DE VALIDADE. |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 06/05/2016 |