BRPI1013748A2 - "compostos de vinil-indazolila" - Google Patents

"compostos de vinil-indazolila"

Info

Publication number
BRPI1013748A2
BRPI1013748A2 BRPI1013748A BRPI1013748A BRPI1013748A2 BR PI1013748 A2 BRPI1013748 A2 BR PI1013748A2 BR PI1013748 A BRPI1013748 A BR PI1013748A BR PI1013748 A BRPI1013748 A BR PI1013748A BR PI1013748 A2 BRPI1013748 A2 BR PI1013748A2
Authority
BR
Brazil
Prior art keywords
vinyl
compounds
indazolyl compounds
vinyl indazolyl
indazolyl
Prior art date
Application number
BRPI1013748A
Other languages
English (en)
Inventor
Daohong Chen
Genshi Zhao
Hong-Yu Li
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI1013748A2 publication Critical patent/BRPI1013748A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
BRPI1013748A 2009-05-07 2010-05-04 "compostos de vinil-indazolila" BRPI1013748A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17629009P 2009-05-07 2009-05-07
US30141610P 2010-02-04 2010-02-04
PCT/US2010/033487 WO2010129509A1 (en) 2009-05-07 2010-05-04 Vinyl indazolyl compounds

Publications (1)

Publication Number Publication Date
BRPI1013748A2 true BRPI1013748A2 (pt) 2016-04-05

Family

ID=42238704

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013748A BRPI1013748A2 (pt) 2009-05-07 2010-05-04 "compostos de vinil-indazolila"

Country Status (35)

Country Link
US (1) US8268869B2 (pt)
EP (1) EP2427449B1 (pt)
JP (1) JP5555314B2 (pt)
KR (1) KR101373910B1 (pt)
CN (1) CN102421769B (pt)
AR (1) AR078411A1 (pt)
AU (1) AU2010246114B2 (pt)
BR (1) BRPI1013748A2 (pt)
CA (1) CA2760535C (pt)
CL (1) CL2011002781A1 (pt)
CO (1) CO6450624A2 (pt)
CR (1) CR20110580A (pt)
DK (1) DK2427449T3 (pt)
EA (1) EA018149B1 (pt)
EC (1) ECSP11011441A (pt)
ES (1) ES2408117T3 (pt)
HK (1) HK1163665A1 (pt)
HN (1) HN2011002809A (pt)
HR (1) HRP20130323T1 (pt)
IL (1) IL216004A (pt)
JO (1) JO2860B1 (pt)
MA (1) MA33244B1 (pt)
ME (1) ME01462B (pt)
MX (1) MX2011011342A (pt)
MY (1) MY160390A (pt)
NZ (1) NZ595553A (pt)
PE (2) PE20120812A1 (pt)
PL (1) PL2427449T3 (pt)
PT (1) PT2427449E (pt)
RS (1) RS52795B (pt)
SG (1) SG175909A1 (pt)
SI (1) SI2427449T1 (pt)
TW (1) TWI382982B (pt)
UA (1) UA104756C2 (pt)
WO (1) WO2010129509A1 (pt)

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JO3062B1 (ar) * 2010-10-05 2017-03-15 Lilly Co Eli R)-(e)-2-(4-(2-(5-(1-(3، 5-داي كلورو بيريدين-4-يل)إيثوكسي)-1h-إندازول-3-يل)?ينيل)-1h-بيرازول-1-يل)إيثانول بلوري
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9481911B2 (en) 2012-03-08 2016-11-01 Astellas Pharma Inc. Methods for detecting FGFR3/TACC3 fusion genes
EP3822273B1 (en) 2012-06-13 2024-04-10 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
US20150203589A1 (en) 2012-07-24 2015-07-23 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
KR20150129847A (ko) 2013-03-15 2015-11-20 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 융합 단백질 및 이들의 방법
SG10201708520YA (en) 2013-04-19 2017-12-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EP3237452A4 (en) 2014-12-23 2018-12-05 The Trustees of Columbia University in the City of New York Fusion proteins and methods thereof
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MX2017010673A (es) 2015-02-20 2018-03-21 Incyte Corp Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr).
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN105906621A (zh) * 2015-04-06 2016-08-31 四川百利药业有限责任公司 用作fgfr抑制剂的乙醇类化合物
WO2016187767A1 (en) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Pharmaceutical compositions and use thereof
EP3333157B1 (en) * 2015-08-07 2020-12-23 Harbin Zhenbao Pharmaceutical Co., Ltd. Vinyl compounds as fgfr and vegfr inhibitors
US10214515B2 (en) 2015-08-20 2019-02-26 Zhejiang Hisun Pharmaceutical Co., Ltd. Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
CN107459519A (zh) 2016-06-06 2017-12-12 上海艾力斯医药科技有限公司 稠合嘧啶哌啶环衍生物及其制备方法和应用
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN112867716A (zh) 2018-05-04 2021-05-28 因赛特公司 Fgfr抑制剂的固体形式和其制备方法
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
AU2020366006A1 (en) 2019-10-14 2022-04-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021088859A1 (zh) * 2019-11-06 2021-05-14 暨南大学 吲唑类化合物及其药用组合物和应用
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
WO2021138391A1 (en) * 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
WO2022033472A1 (zh) * 2020-08-11 2022-02-17 河南迈英诺医药科技有限公司 Fgfr抑制剂化合物及其用途
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors

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US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
DK1650203T3 (da) 2000-09-11 2008-06-02 Novartis Vaccines & Diagnostic Quinolinonderivater som tyrosinkinaseinhibitorer
EP1447405A4 (en) * 2001-10-17 2005-01-12 Kirin Brewery QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS
IL164209A0 (en) * 2002-05-31 2005-12-18 Eisai Co Ltd Pyrazole derivatives and pharmaceutical compositions containing the same
DE10342503A1 (de) * 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
EP1753763B1 (en) 2004-05-26 2008-08-13 Pfizer Limited Indazole and indolone derivatives and their use as pharmaceuticals
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
JP2009531274A (ja) * 2005-12-07 2009-09-03 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド キナーゼ阻害性ピロロピリジン化合物
DK2120932T3 (da) 2006-12-20 2014-10-13 Nerviano Medical Sciences Srl Indazolderivater som kinasehæmmere til behandling af kræft
US7737149B2 (en) * 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
BRPI0812450A2 (pt) 2007-06-05 2019-09-24 Schering Corp derivados de indazol policíclicos e seu uso como inibidores de erk para o tratamento de câncer
DE102007028521A1 (de) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
EP2265270A1 (en) * 2008-02-04 2010-12-29 OSI Pharmaceuticals, Inc. 2-aminopyridine kinase inhibitors

Also Published As

Publication number Publication date
HRP20130323T1 (en) 2013-05-31
MX2011011342A (es) 2011-11-18
IL216004A (en) 2014-01-30
ECSP11011441A (es) 2011-12-30
TWI382982B (zh) 2013-01-21
WO2010129509A1 (en) 2010-11-11
MY160390A (en) 2017-03-15
AU2010246114B2 (en) 2012-12-06
EA201171367A1 (ru) 2012-04-30
IL216004A0 (en) 2012-01-31
EP2427449B1 (en) 2013-04-03
CA2760535A1 (en) 2010-11-11
AU2010246114A1 (en) 2011-11-03
KR101373910B1 (ko) 2014-03-12
TW201105652A (en) 2011-02-16
JP5555314B2 (ja) 2014-07-23
CO6450624A2 (es) 2012-05-31
UA104756C2 (uk) 2014-03-11
CN102421769B (zh) 2014-04-02
HK1163665A1 (en) 2012-09-14
SI2427449T1 (sl) 2013-05-31
ME01462B (me) 2014-04-20
PE20120812A1 (es) 2012-07-08
JO2860B1 (en) 2015-03-15
RS52795B (en) 2013-10-31
CL2011002781A1 (es) 2012-05-25
CA2760535C (en) 2014-01-14
US20100286209A1 (en) 2010-11-11
DK2427449T3 (da) 2013-04-22
AR078411A1 (es) 2011-11-09
NZ595553A (en) 2013-05-31
CR20110580A (es) 2012-01-06
PL2427449T3 (pl) 2013-08-30
MA33244B1 (fr) 2012-05-02
CN102421769A (zh) 2012-04-18
PE20160124A1 (es) 2016-02-24
EA018149B1 (ru) 2013-05-30
US8268869B2 (en) 2012-09-18
ES2408117T3 (es) 2013-06-18
SG175909A1 (en) 2011-12-29
HN2011002809A (es) 2013-07-22
PT2427449E (pt) 2013-05-06
KR20120004511A (ko) 2012-01-12
EP2427449A1 (en) 2012-03-14
JP2012526126A (ja) 2012-10-25

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]