BRPI1012956A8 - Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato - Google Patents

Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato

Info

Publication number
BRPI1012956A8
BRPI1012956A8 BRPI1012956A BRPI1012956A BRPI1012956A8 BR PI1012956 A8 BRPI1012956 A8 BR PI1012956A8 BR PI1012956 A BRPI1012956 A BR PI1012956A BR PI1012956 A BRPI1012956 A BR PI1012956A BR PI1012956 A8 BRPI1012956 A8 BR PI1012956A8
Authority
BR
Brazil
Prior art keywords
phenylacetate
ornithine
phenylbutyrate
treating
disclosed
Prior art date
Application number
BRPI1012956A
Other languages
English (en)
Portuguese (pt)
Inventor
Keith Anderson
Rajiv Jalan
Original Assignee
Ocera Therapeutics Inc
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocera Therapeutics Inc, Ucl Business Plc filed Critical Ocera Therapeutics Inc
Publication of BRPI1012956A2 publication Critical patent/BRPI1012956A2/pt
Publication of BRPI1012956A8 publication Critical patent/BRPI1012956A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
BRPI1012956A 2009-06-08 2010-06-08 Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato BRPI1012956A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18515809P 2009-06-08 2009-06-08
US24074809P 2009-09-09 2009-09-09
US29637710P 2010-01-19 2010-01-19
PCT/US2010/037838 WO2010144498A2 (en) 2009-06-08 2010-06-08 Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate

Publications (2)

Publication Number Publication Date
BRPI1012956A2 BRPI1012956A2 (pt) 2017-06-06
BRPI1012956A8 true BRPI1012956A8 (pt) 2021-11-03

Family

ID=43309444

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012956A BRPI1012956A8 (pt) 2009-06-08 2010-06-08 Usos da l-ornitina e de pelo menos um de fenilacetato e fenilbutirato

Country Status (18)

Country Link
US (2) US20120157526A1 (https=)
EP (3) EP2799067B1 (https=)
JP (3) JP5749255B2 (https=)
KR (2) KR20170026672A (https=)
CN (2) CN104434894A (https=)
AU (1) AU2010258888B2 (https=)
BR (1) BRPI1012956A8 (https=)
CA (2) CA2764587C (https=)
DK (2) DK2799067T3 (https=)
EA (2) EA201691430A1 (https=)
ES (2) ES2728948T3 (https=)
IL (2) IL216811A (https=)
MX (3) MX375116B (https=)
NZ (2) NZ615091A (https=)
PL (1) PL2440200T3 (https=)
SG (1) SG176675A1 (https=)
WO (1) WO2010144498A2 (https=)
ZA (1) ZA201108988B (https=)

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CA2757373C (en) 2009-04-03 2018-05-08 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
EA201691430A1 (ru) 2009-06-08 2017-02-28 ЮСиЭл БИЗНЕС ПиЭлСи Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата
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US10039735B2 (en) * 2014-11-24 2018-08-07 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
AR103384A1 (es) 2015-01-12 2017-05-03 Umecrine Cognition Ab 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA
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JP2017014206A (ja) * 2015-06-30 2017-01-19 ナノアンティバイオティクス，インコーポレイテッド 腹水の治療
EP3337473A4 (en) * 2015-08-18 2019-04-17 Ocera Therapeutics, Inc. TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE
AU2016325556B2 (en) * 2015-09-25 2023-02-16 Ocera Therapeutics, Inc. Treatment and prevention of neuronal cell loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US11219611B2 (en) * 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
AU2016353350B2 (en) * 2015-11-13 2021-09-23 Ocera Therapeutics, Inc. Formulation of L-ornithine phenylacetate
CN106109429A (zh) * 2016-07-26 2016-11-16 北京百奥药业有限责任公司 一种苯丁酸钠片剂及其制备方法
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
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WO2018208677A1 (en) 2017-05-11 2018-11-15 Ocera Therapeutics, Inc. Processes of making l-ornithine phenylacetate
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WO2019173148A1 (en) * 2018-03-05 2019-09-12 The United States Government As Represented By The United States Department Of Veterans Affairs Cholesterol lowering drugs for the treatment of hepatic encephalopathy
MA52971A (fr) 2018-06-20 2021-04-28 Axcella Health Inc Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle
KR102852068B1 (ko) 2019-05-09 2025-08-28 오세라 테라퓨틱스, 아이엔씨. 간성 뇌증의 평가 및 치료 방법
KR20220011697A (ko) 2019-05-22 2022-01-28 바이오비에 아이앤씨. 테를리프레신 제형
KR102237526B1 (ko) * 2019-11-07 2021-04-07 한국식품연구원 오르니틴 생성능이 우수한 락토바실러스 브레비스 wikim47를 이용한 마늘 발효 조성물
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Also Published As

Publication number Publication date
IL248696A0 (en) 2016-12-29
EA201691430A1 (ru) 2017-02-28
HK1203419A1 (en) 2015-10-30
CA2764587C (en) 2018-04-24
SG176675A1 (en) 2012-01-30
BRPI1012956A2 (pt) 2017-06-06
EA025735B1 (ru) 2017-01-30
JP2012529523A (ja) 2012-11-22
KR20120047891A (ko) 2012-05-14
EP2440200B1 (en) 2014-08-27
JP2015163635A (ja) 2015-09-10
MX2020009703A (es) 2020-10-07
JP5749255B2 (ja) 2015-07-15
US11266620B2 (en) 2022-03-08
CA2764587A1 (en) 2010-12-16
EP3517110A1 (en) 2019-07-31
ZA201108988B (en) 2015-04-29
DK2440200T3 (en) 2014-12-08
EP2799067A1 (en) 2014-11-05
WO2010144498A9 (en) 2011-04-28
CN102625699A (zh) 2012-08-01
KR101715008B1 (ko) 2017-03-22
AU2010258888A1 (en) 2012-02-02
US20180161293A1 (en) 2018-06-14
WO2010144498A2 (en) 2010-12-16
CA2997484C (en) 2020-05-12
CA2997484A1 (en) 2010-12-16
JP6527497B2 (ja) 2019-06-05
EP2799067B1 (en) 2019-04-03
JP2017066153A (ja) 2017-04-06
NZ596916A (en) 2013-09-27
CN104434894A (zh) 2015-03-25
EP2440200B8 (en) 2014-10-15
ES2517340T3 (es) 2014-11-03
EP2440200A2 (en) 2012-04-18
NZ615091A (en) 2015-03-27
EA201171396A1 (ru) 2012-10-30
PL2440200T3 (pl) 2015-08-31
MX2011013129A (es) 2012-03-14
CN102625699B (zh) 2014-08-20
IL216811A (en) 2016-11-30
DK2799067T3 (da) 2019-06-03
IL248696B (en) 2020-05-31
MX375116B (es) 2025-03-06
EP2440200A4 (en) 2012-11-28
HK1174264A1 (en) 2013-06-07
KR20170026672A (ko) 2017-03-08
US20120157526A1 (en) 2012-06-21
AU2010258888B2 (en) 2014-08-07
ES2728948T3 (es) 2019-10-29
IL216811A0 (en) 2012-02-29
JP6250588B2 (ja) 2017-12-20

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