BRPI1009447A2 - métodos de purificação de proteínas imunofarmacêuticas modulares pequenas - Google Patents

métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Info

Publication number
BRPI1009447A2
BRPI1009447A2 BRPI1009447A BRPI1009447A BRPI1009447A2 BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2 BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A BRPI1009447 A BR PI1009447A BR PI1009447 A2 BRPI1009447 A2 BR PI1009447A2
Authority
BR
Brazil
Prior art keywords
protein purification
purification methods
small modular
modular immunopharmaceutical
immunopharmaceutical protein
Prior art date
Application number
BRPI1009447A
Other languages
English (en)
Inventor
Aaron Noyes
Christopher Gallo
Daniel Lacasse
James Edward Booth
Jason Cormier
Shujun Sun
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BRPI1009447A2 publication Critical patent/BRPI1009447A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BRPI1009447A 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas BRPI1009447A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15934709P 2009-03-11 2009-03-11
PCT/US2010/026931 WO2010147686A2 (en) 2009-03-11 2010-03-11 Methods of purifying small modular immunopharmaceutical proteins

Publications (1)

Publication Number Publication Date
BRPI1009447A2 true BRPI1009447A2 (pt) 2016-03-01

Family

ID=43012630

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009447A BRPI1009447A2 (pt) 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Country Status (11)

Country Link
US (1) US20120141497A1 (pt)
EP (1) EP2406274A2 (pt)
JP (1) JP2010209068A (pt)
KR (1) KR20110139216A (pt)
CN (1) CN102395597A (pt)
AU (1) AU2010260476A1 (pt)
BR (1) BRPI1009447A2 (pt)
CA (1) CA2751000A1 (pt)
IL (1) IL215082A0 (pt)
RU (1) RU2011137030A (pt)
WO (1) WO2010147686A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2813398T3 (es) * 2009-10-20 2021-03-23 Abbvie Inc Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
WO2011089212A1 (de) * 2010-01-22 2011-07-28 Boehringer Ingelheim International Gmbh Chromatographisches verfahren zur aufreinigung von fc enthaltenden proteinen
US20110301333A1 (en) * 2010-06-08 2011-12-08 Millipore Corporation Removal of protein aggregates from biopharmaceutical preparations using calcium phosphate salts
AR082963A1 (es) 2010-09-17 2013-01-23 Sumitomo Chemical Co Composicion para aerosol de control de plagas
JP6023715B2 (ja) * 2010-10-11 2016-11-09 アッヴィ・バハマズ・リミテッド タンパク質の精製方法
EP3216877B1 (en) * 2011-08-12 2020-10-21 QIAGEN GmbH Method for isolating nucleic acids
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法
AU2013344375B2 (en) 2012-11-16 2017-09-14 Transposagen Biopharmaceuticals, Inc. Site-specific enzymes and methods of use
CN102993266B (zh) * 2012-11-30 2019-08-23 广州白云山拜迪生物医药有限公司 一种融合蛋白的纯化和复性方法
PL3395423T3 (pl) 2013-03-14 2024-03-18 Amgen Inc. Usuwanie wypłukanych ligandów do oczyszczania na zasadzie powinowactwa
AU2014233451B2 (en) * 2013-03-15 2018-07-12 Genzyme Corporation Affinity-based analytical purification of biotherapeutics for bioprocess monitoring
CA2952613A1 (en) * 2014-06-17 2015-12-23 Poseida Therapeutics, Inc. A method for directing proteins to specific loci in the genome and uses thereof
CA2958144A1 (en) * 2014-08-15 2016-02-18 Oncomed Pharmaceuticals, Inc. Rspo1 binding agents and uses thereof
CN107001411B (zh) 2014-12-15 2021-07-23 默克专利股份公司 从粗溶液捕获靶分子
CN104693303B (zh) * 2015-02-28 2018-03-13 苏州金盟生物技术有限公司 一种蛋白制品中的核酸去除方法
KR102637402B1 (ko) 2015-06-17 2024-02-15 포세이다 테라퓨틱스, 인크. 게놈 내 특정 유전자좌에 단백질을 유도하기 위한 조성물 및 방법
JP2019108274A (ja) * 2016-04-18 2019-07-04 昭和電工株式会社 タンパク質凝集体の除去方法
EP3519070A4 (en) * 2016-09-29 2020-05-06 Bio-Rad Laboratories, Inc. AGAROSE-FILLED CERAMIC APATITE
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
WO2020125757A1 (en) * 2018-12-21 2020-06-25 Wuxi Biologics (Shanghai) Co., Ltd. A method for improving aggregate removal by protein a chromatography
US20220314142A1 (en) * 2019-07-01 2022-10-06 Pfizer Inc. Improvements to wash solutions for protein a chromatography in an antibody purification process
WO2021072265A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
MX2022008323A (es) * 2020-01-08 2022-08-08 Regeneron Pharma Uso de aminoácidos para mejorar la señal en análisis del espectro de masas.
EP4093745A4 (en) * 2020-01-20 2024-03-06 Wuxi Biologics Ireland Limited NEW WASH BUFFER SOLUTION FOR AFFINITY CHROMATOGRAPHY
AU2023217074A1 (en) * 2022-02-10 2024-08-15 Kodiak Sciences Inc. Methods of purifying a product
CN115894604B (zh) * 2022-12-16 2024-01-23 康日百奥生物科技(苏州)有限公司 重组蛋白澄清纯化方法
CN116120392B (zh) * 2023-04-18 2023-08-01 上海健士拜生物科技有限公司 聚体蛋白的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2316951A1 (en) 2001-01-17 2011-05-04 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US20040058445A1 (en) 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
SI1648940T1 (sl) 2003-07-28 2016-08-31 Genentech, Inc. Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A
CA2543193C (en) * 2003-10-27 2015-08-11 Wyeth Removal of high molecular weight aggregates using hydroxyapatite chromatography
RU2421242C2 (ru) * 2005-07-25 2011-06-20 Трабьон Фармасьютикалз, Инк. Применение однократной дозы cd20-специфических связывающих молекул
KR20090064377A (ko) 2006-09-08 2009-06-18 와이어쓰 친화성 크로마토그래피를 사용하는 단백질 정제에 있어서 아르기닌 세척
CN101522219A (zh) * 2006-10-12 2009-09-02 惠氏公司 改变抗体溶液中离子强度以减少乳光/聚集物
US7846434B2 (en) * 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
RU2010100638A (ru) 2007-06-12 2011-07-20 УАЙТ ЭлЭлСи (US) Композиции и способы лечения, направленные против cd20
US10118962B2 (en) * 2008-10-29 2018-11-06 Ablynx N.V. Methods for purification of single domain antigen binding molecules

Also Published As

Publication number Publication date
CN102395597A (zh) 2012-03-28
KR20110139216A (ko) 2011-12-28
WO2010147686A3 (en) 2011-02-24
CA2751000A1 (en) 2010-12-23
US20120141497A1 (en) 2012-06-07
AU2010260476A1 (en) 2011-10-13
EP2406274A2 (en) 2012-01-18
IL215082A0 (en) 2011-11-30
RU2011137030A (ru) 2013-04-20
WO2010147686A2 (en) 2010-12-23
JP2010209068A (ja) 2010-09-24

Similar Documents

Publication Publication Date Title
BRPI1009447A2 (pt) métodos de purificação de proteínas imunofarmacêuticas modulares pequenas
HK1246330A1 (zh) 蛋白質純化
HRP20181357T1 (hr) Novi postupci pročišćavanja proteina
SMT201500142B (it) Procedimento per la purificazione di proteine
BRPI1012605A2 (pt) método de limpeza
BR112012005146A2 (pt) fotobiorreator
BRPI1015220A2 (pt) purificador de água
EP2519536A4 (en) PROTEIN PURIFICATION BY ION EXCHANGE
DK2307543T3 (da) Forbedret proteinekspressionssystem
DK2273004T3 (da) Rensesystem
BR112012004402A2 (pt) glicosilação de proteína
BR212012009026U2 (pt) escova de dentes
BRPI1009018A2 (pt) fotobiorreator
EP2519537A4 (en) CLEANING PROTEINS
BRPI0922716A2 (pt) purificação de polipeptídeo
FI20105919A0 (fi) Menetelmä veden puhdistamiseksi
BRPI1010121A2 (pt) método de tratamento biológico
BRPI1015272A2 (pt) Fermentação
FR2946103B1 (fr) Support modulaire
IL229383A0 (en) A process for purifying protein with a low acidity level
FI20096202A0 (fi) Biologinen regeneraatti
BRPI0920524A2 (pt) método de purificação
BRPI1006155A2 (pt) purificador de água
DK2424661T3 (da) Zeolit y
FI20095795A0 (fi) Menetelmä biologiseen puhdistamiseen

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]