BRPI1008359B8 - método para produzir partículas de medicamento de tamanho de partícula pequeno - Google Patents
método para produzir partículas de medicamento de tamanho de partícula pequenoInfo
- Publication number
- BRPI1008359B8 BRPI1008359B8 BRPI1008359A BRPI1008359A BRPI1008359B8 BR PI1008359 B8 BRPI1008359 B8 BR PI1008359B8 BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 A BRPI1008359 A BR PI1008359A BR PI1008359 B8 BRPI1008359 B8 BR PI1008359B8
- Authority
- BR
- Brazil
- Prior art keywords
- solvent
- particle size
- small particle
- water
- drug particles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Abstract
método para produzir partículas de medicamento de tamanho de partículas pequeno. as partículas de medicamento de tamanho de partícula pequeno são produzidas pela combinação de um precipitado de solvente-não solvente com um processo de secagem por atomização in situ. um mediamento é disperso em um solvente miscível em água, em particular etanol, e aquecido em uma linha de alimentação sob pressão até acima do ponto de ebulição do solvente até o fármaco dissolver. esta solução colide como um jato de líquido fino com um jato de água fino em um microreator permeado por gás, e a névoa fina assim formada vaporiza rapidamente. o solvente orgânico vaporiza primeiro, depois a água. a água pode conter modificadores de superfície.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102009008478A DE102009008478A1 (de) | 2009-02-11 | 2009-02-11 | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
DE102009008478.9 | 2009-02-11 | ||
PCT/DE2010/075015 WO2010091683A2 (de) | 2009-02-11 | 2010-02-11 | Vorrichtung und verfahren zur herstellung pharmazeutisch hochfeiner partikel sowie zur beschichtung solcher partikel in mikroreaktoren |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI1008359A2 BRPI1008359A2 (pt) | 2016-02-23 |
BRPI1008359B1 BRPI1008359B1 (pt) | 2021-01-12 |
BRPI1008359B8 true BRPI1008359B8 (pt) | 2021-05-25 |
Family
ID=42338614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1008359A BRPI1008359B8 (pt) | 2009-02-11 | 2010-02-11 | método para produzir partículas de medicamento de tamanho de partícula pequeno |
Country Status (9)
Country | Link |
---|---|
US (1) | US8697131B2 (pt) |
EP (1) | EP2395978B1 (pt) |
JP (1) | JP5624059B2 (pt) |
KR (1) | KR101515263B1 (pt) |
CN (2) | CN102316853A (pt) |
BR (1) | BRPI1008359B8 (pt) |
CA (1) | CA2751625C (pt) |
DE (1) | DE102009008478A1 (pt) |
WO (1) | WO2010091683A2 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112012023983B1 (pt) | 2010-03-22 | 2019-03-26 | Instillo Gmbh | Método e dispositivo para fabricação de micro ou nanopartículas |
US20120167410A1 (en) * | 2010-12-21 | 2012-07-05 | Basf Se | Spray drying techniques |
CN103127889B (zh) * | 2011-11-29 | 2016-01-13 | 北京大学 | 制备功能纳米粒子的减压诱导微射流混合法及其应用 |
JP2016515934A (ja) * | 2013-03-28 | 2016-06-02 | インスティロ ゲーエムベーハー | 分散物および固体の生産のための装置および方法 |
US9468626B2 (en) | 2014-03-13 | 2016-10-18 | Chiesi Farmaceutici S.P.A. | Melatonin-based formulations for parenteral administration |
CN114668740A (zh) | 2014-05-19 | 2022-06-28 | 奇斯药制品公司 | 氯维地平纳米颗粒及其药物组合物 |
CN104226211B (zh) * | 2014-09-17 | 2018-08-10 | 天津春发生物科技集团有限公司 | 一种生物-喷雾干燥法制备香精微胶囊的方法 |
DE202015100863U1 (de) | 2015-02-23 | 2016-05-30 | Care Connection Gmbh | Behälter zur Applikation einer Tannin-enthaltenden Deodorant- oder Antitranspirantzusammensetzung |
DE202015100862U1 (de) | 2015-02-23 | 2016-05-30 | Care Connection Gmbh | Tannin-Nanopartikel enthaltende Deodorant- oder Antitranspirantzusammensetzung |
WO2016146516A1 (en) * | 2015-03-17 | 2016-09-22 | Leon-Nanodrugs Gmbh | Nanoparticles comprising a stabilized boronic acid compound |
DE102016101232A1 (de) | 2016-01-25 | 2017-07-27 | Instillo Gmbh | Verfahren zum Herstellen von Emulsionen |
DE102017110292B4 (de) | 2017-05-11 | 2020-06-10 | Instillo Gmbh | Verfahren zum Herstellen von Reaktionsprodukten |
MA52122A (fr) | 2018-03-02 | 2021-04-28 | Chiesi Farm Spa | Formulation pharmaceutique pour administration intraduodénale comprenant de la mélévodopa et de la carbidopa |
CN110385124B (zh) * | 2018-04-16 | 2021-01-26 | 浙江大学 | 一种通过分段反应制备MnOx-CeO2混合氧化物催化剂的方法 |
US10912326B2 (en) | 2018-08-22 | 2021-02-09 | Rachelle MACSWEENEY | Nanoformulations containing encapsulted omega-3 fatty acids |
DE102019112382A1 (de) * | 2019-05-13 | 2020-11-19 | MyBiotech GmbH | Verwendung eines MikroJet-Reaktors zum Zellaufschluss |
JP2022533463A (ja) | 2019-05-23 | 2022-07-22 | ヘルム・アクチエンゲゼルシャフト | エンザルタミドを含むナノ粒子 |
EP3795646A1 (de) | 2019-12-19 | 2021-03-24 | nanoSaar Lab GmbH | Farb- und füllstoffpasten unter verwendung anorganischer partikel mit beschichteter oberfläche als spacer |
EP4008322A1 (de) | 2020-05-25 | 2022-06-08 | Leon-Nanodrugs GmbH | Lecithin-partikel im nanometer bereich als wirkstoffträger zur parenteralen verabreichung |
EP3915544A1 (en) | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Method for producing a liposome dispersion |
EP3915546A1 (de) * | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Verwendung von säure als lösungsmittel für präzipitationen |
EP3915673A1 (de) | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Verfahren zur überprüfung der funktionsfähigkeit einer anlage zur herstellung von nanopartikeln durch gezielte fällung aus übersättigten lösungen |
EP4333808A1 (en) | 2021-05-05 | 2024-03-13 | leon-nanodrugs GmbH | Methods for producing nanoparticle dispersions |
EP4163006B8 (en) | 2021-10-11 | 2024-03-20 | leon-nanodrugs GmbH | Methods for validating an apparatus for producing nanoparticles |
EP4198105A1 (en) | 2021-12-16 | 2023-06-21 | Seaborough IP I B.V. | Microjet reactor based synthesis of nanophosphors |
CN114669085A (zh) * | 2022-01-28 | 2022-06-28 | 南京宁源科生物技术有限公司 | 一种药用颗粒的有机溶剂去除装置 |
Family Cites Families (16)
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JP3282731B2 (ja) | 1990-06-15 | 2002-05-20 | メルク エンド カムパニー インコーポレーテッド | 結晶の構造および大きさを改良する結晶化方法 |
DE19617085A1 (de) | 1996-04-29 | 1997-10-30 | Bayer Ag | Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten |
GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
WO2000061275A2 (de) | 1999-04-08 | 2000-10-19 | Bernd Penth | Verfahren und vorrichtung zur durchführung chemischer und physikalischer prozesse |
YU34501A (sh) | 2000-05-26 | 2003-10-31 | Pfizer Products Inc. | Postupak reaktivne kristalizacije radi povećanja veličine čestica |
ATE319432T1 (de) | 2000-12-22 | 2006-03-15 | Baxter Int | Verfahren zur herstellung von submikropartikel- suspensionen pharmazeutischer substanzen |
US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
US7041144B2 (en) * | 2003-03-04 | 2006-05-09 | Five Star Technologies, Inc. | Hydrodynamic cavitation crystallization process |
KR20060052849A (ko) | 2003-08-06 | 2006-05-19 | 에자이 가부시키가이샤 | 약물 초미립자의 제조 방법 및 제조 장치 |
TWI371274B (en) * | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
DE102005048201A1 (de) | 2004-10-11 | 2006-04-20 | Penth, Bernd, Dr. | Kontinuierliche Fällung von nanoskaligen Produkten in Mikroreaktoren |
DE102005011786A1 (de) | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
DE102005017777A1 (de) | 2005-04-13 | 2006-10-19 | Pharmasol Gmbh | Verfahren zur schonenden Herstellung von hochfeinen Partikelsuspensionen |
DE102005048021B3 (de) | 2005-10-06 | 2007-04-12 | Abb Patent Gmbh | Lokal bedienbares Automatisierungsgerät |
DE102005053862A1 (de) | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
-
2009
- 2009-02-11 DE DE102009008478A patent/DE102009008478A1/de not_active Withdrawn
-
2010
- 2010-02-11 CN CN2010800073233A patent/CN102316853A/zh active Pending
- 2010-02-11 BR BRPI1008359A patent/BRPI1008359B8/pt active IP Right Grant
- 2010-02-11 JP JP2011548532A patent/JP5624059B2/ja active Active
- 2010-02-11 US US13/138,389 patent/US8697131B2/en active Active
- 2010-02-11 WO PCT/DE2010/075015 patent/WO2010091683A2/de active Application Filing
- 2010-02-11 KR KR1020117021104A patent/KR101515263B1/ko active IP Right Grant
- 2010-02-11 CA CA2751625A patent/CA2751625C/en active Active
- 2010-02-11 CN CN201510359931.5A patent/CN105125502A/zh active Pending
- 2010-02-11 EP EP10710995.1A patent/EP2395978B1/de active Active
Also Published As
Publication number | Publication date |
---|---|
BRPI1008359A2 (pt) | 2016-02-23 |
KR20110118714A (ko) | 2011-10-31 |
EP2395978B1 (de) | 2015-05-27 |
DE102009008478A1 (de) | 2010-08-19 |
CN105125502A (zh) | 2015-12-09 |
JP5624059B2 (ja) | 2014-11-12 |
CA2751625C (en) | 2014-10-14 |
WO2010091683A2 (de) | 2010-08-19 |
KR101515263B1 (ko) | 2015-04-24 |
WO2010091683A3 (de) | 2010-10-21 |
CN102316853A (zh) | 2012-01-11 |
BRPI1008359B1 (pt) | 2021-01-12 |
US20110294770A1 (en) | 2011-12-01 |
CA2751625A1 (en) | 2010-08-19 |
US8697131B2 (en) | 2014-04-15 |
JP2012517403A (ja) | 2012-08-02 |
EP2395978A2 (de) | 2011-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: INSTILLO GMBH (DE) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/01/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/02/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |