BRPI0919020A8 - terapia celular de tecido isquêmico - Google Patents

terapia celular de tecido isquêmico Download PDF

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Publication number
BRPI0919020A8
BRPI0919020A8 BRPI0919020A BRPI0919020A BRPI0919020A8 BR PI0919020 A8 BRPI0919020 A8 BR PI0919020A8 BR PI0919020 A BRPI0919020 A BR PI0919020A BR PI0919020 A BRPI0919020 A BR PI0919020A BR PI0919020 A8 BRPI0919020 A8 BR PI0919020A8
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BR
Brazil
Prior art keywords
cell therapy
tissue cell
ischemic tissue
ischemic
therapy
Prior art date
Application number
BRPI0919020A
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English (en)
Inventor
Invitti Adriana
E Willing Alison
Hossne Nelson
R Sanberg Paul
Original Assignee
Cryopraxis Criobiologia Ltda
Univ Federal De Sao Paulo Unifesp
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryopraxis Criobiologia Ltda, Univ Federal De Sao Paulo Unifesp, Univ South Florida filed Critical Cryopraxis Criobiologia Ltda
Publication of BRPI0919020A8 publication Critical patent/BRPI0919020A8/pt
Publication of BRPI0919020B1 publication Critical patent/BRPI0919020B1/pt
Publication of BRPI0919020B8 publication Critical patent/BRPI0919020B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration

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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
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  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
BRPI0919020A 2008-09-12 2009-09-14 uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris BRPI0919020B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9672708P 2008-09-12 2008-09-12
US61/096,727 2008-09-12
US17380709P 2009-04-29 2009-04-29
US61/173,807 2009-04-29
PCT/US2009/056867 WO2010031006A1 (en) 2008-09-12 2009-09-14 Ischemic tissue cell therapy

Publications (3)

Publication Number Publication Date
BRPI0919020A8 true BRPI0919020A8 (pt) 2018-05-29
BRPI0919020B1 BRPI0919020B1 (pt) 2021-03-23
BRPI0919020B8 BRPI0919020B8 (pt) 2021-05-25

Family

ID=42005531

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0919020A BRPI0919020B8 (pt) 2008-09-12 2009-09-14 uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris
BRPI0919020D BRPI0919020A2 (pt) 2008-09-12 2009-09-14 Uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0919020D BRPI0919020A2 (pt) 2008-09-12 2009-09-14 Uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris

Country Status (9)

Country Link
US (2) US8784802B2 (pt)
EP (1) EP2331679B1 (pt)
JP (4) JP6105846B2 (pt)
CN (2) CN102186970A (pt)
BR (2) BRPI0919020B8 (pt)
CA (1) CA2737193A1 (pt)
HK (1) HK1248125A1 (pt)
RU (1) RU2535966C2 (pt)
WO (1) WO2010031006A1 (pt)

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CN101940594B (zh) * 2010-08-27 2013-12-04 上海士腾生物技术有限公司 用于治疗缺血性心血管疾病的制剂及其制备方法
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JP6903866B2 (ja) * 2016-01-27 2021-07-14 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
SG11201901594RA (en) * 2016-08-26 2019-03-28 Rexgenero Biosciences S L Cell suspension for use in the treatment of lower extremity peripheral artery disease
DK3580330T3 (da) 2017-02-13 2022-12-05 Hopitaux Paris Assist Publique Fremgangsmåde til generering af t-celleprogenitorer
WO2018200606A1 (en) * 2017-04-25 2018-11-01 Abraham J And Phyllis Katz Cord Blood Foundation Enriched cellular compositions and therapeutic use
RU2661048C1 (ru) * 2017-12-28 2018-07-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ лечения больных острым инфарктом миокарда с поздней госпитализацией
JP7466547B2 (ja) 2019-08-09 2024-04-12 公益財団法人神戸医療産業都市推進機構 血管内皮細胞活性化物質のスクリーニング方法
RU2725860C1 (ru) * 2019-12-26 2020-07-06 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский университет "Московский институт электронной техники" Тканеинженерная конструкция для регенерации сердечной ткани
US20220202860A1 (en) * 2020-12-30 2022-06-30 Creative Medical Technologies, Inc. Treatment of heart failure and/or post infarct pathological remodeling by ex vivo reprogrammed immune cells

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US20140369983A1 (en) 2014-12-18
CN102186970A (zh) 2011-09-14
RU2535966C2 (ru) 2014-12-20
CA2737193A1 (en) 2010-03-18
HK1248125A1 (zh) 2018-10-12
BRPI0919020A2 (pt) 2017-08-22
BRPI0919020B8 (pt) 2021-05-25
CN107595889A (zh) 2018-01-19
US10335434B2 (en) 2019-07-02
WO2010031006A1 (en) 2010-03-18
JP2012502114A (ja) 2012-01-26
JP2017214426A (ja) 2017-12-07
JP6105846B2 (ja) 2017-03-29
JP2014088443A (ja) 2014-05-15
EP2331679B1 (en) 2017-04-19
US20110274674A1 (en) 2011-11-10
RU2011113869A (ru) 2012-10-20
US8784802B2 (en) 2014-07-22
EP2331679A1 (en) 2011-06-15
JP2016128521A (ja) 2016-07-14
EP2331679A4 (en) 2012-12-26

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