BRPI0918027A2 - enzimas de lise de peptidoglicano artificial e proteínas de ligação de peptidoglicano - Google Patents
enzimas de lise de peptidoglicano artificial e proteínas de ligação de peptidoglicanoInfo
- Publication number
- BRPI0918027A2 BRPI0918027A2 BRPI0918027A BRPI0918027A BRPI0918027A2 BR PI0918027 A2 BRPI0918027 A2 BR PI0918027A2 BR PI0918027 A BRPI0918027 A BR PI0918027A BR PI0918027 A BRPI0918027 A BR PI0918027A BR PI0918027 A2 BRPI0918027 A2 BR PI0918027A2
- Authority
- BR
- Brazil
- Prior art keywords
- peptidoglycan
- artificial
- binding proteins
- lysis enzymes
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08162644A EP2157100A1 (en) | 2008-08-19 | 2008-08-19 | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
PCT/EP2009/060716 WO2010020657A1 (en) | 2008-08-19 | 2009-08-19 | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0918027A2 true BRPI0918027A2 (pt) | 2015-12-01 |
Family
ID=39761130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0918027A BRPI0918027A2 (pt) | 2008-08-19 | 2009-08-19 | enzimas de lise de peptidoglicano artificial e proteínas de ligação de peptidoglicano |
Country Status (8)
Country | Link |
---|---|
US (1) | US20120244595A1 (pt) |
EP (1) | EP2157100A1 (pt) |
JP (1) | JP2012500015A (pt) |
CN (1) | CN102186878A (pt) |
AU (1) | AU2009284175A1 (pt) |
BR (1) | BRPI0918027A2 (pt) |
CA (1) | CA2734829A1 (pt) |
WO (1) | WO2010020657A1 (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
WO2010149795A1 (en) * | 2009-06-26 | 2010-12-29 | Lysando Holding Establishment | Antimicrobial agents |
ES2579806T3 (es) | 2009-06-26 | 2016-08-16 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Agentes antimicrobianos |
FR2949459B1 (fr) * | 2009-08-28 | 2014-10-17 | Otv Sa | Agent de prevention et/ou de lutte contre le moussage biologique |
EP2397548A1 (en) * | 2010-06-18 | 2011-12-21 | Hyglos Invest GmbH | Methods of generating and screening for lytic chimeric polypeptides |
US9382298B2 (en) | 2011-05-04 | 2016-07-05 | Micreos Human Health B.V. | Polypeptide |
EP2714898A1 (en) * | 2011-05-26 | 2014-04-09 | DSM IP Assets B.V. | Endolysins for controlling listeria in pasta filata cheese and related food products |
WO2012159774A1 (en) * | 2011-05-26 | 2012-11-29 | Dsm Ip Assets B.V. | Novel listeria bacteriophage p825n and uses thereof |
CA2851270C (en) * | 2011-10-05 | 2023-03-14 | The Rockefeller University | Dimeric bacteriophage lysins |
US8790639B2 (en) * | 2012-03-28 | 2014-07-29 | The United States Of America, As Represented By The Secretary Of Agriculture | Enhanced antimicrobial lytic activity of a chimeric Ply187 endolysin |
CN102676490B (zh) * | 2012-05-21 | 2013-07-31 | 江苏省农业科学院 | 一种金黄色葡萄球菌噬菌体溶壁酶及其制备方法和应用 |
KR101382893B1 (ko) * | 2012-06-19 | 2014-04-17 | 한국외국어대학교 연구산학협력단 | 슈도모나스 에루기노사의 박테리오파아지 및 그 용도 |
CN102861324A (zh) * | 2012-10-17 | 2013-01-09 | 重庆市第三人民医院 | 治疗耐碳青霉烯类鲍曼不动杆菌感染的生物试剂 |
CN102925447B (zh) * | 2012-11-06 | 2014-04-02 | 中山大学 | 肽聚糖结合蛋白BjApextrin1及其基因、生产方法和应用 |
CN103468704B (zh) * | 2012-11-06 | 2015-01-07 | 中山大学 | 肽聚糖结合蛋白BjApextrin2及其基因、生产方法和应用 |
CN103060232B (zh) * | 2012-12-27 | 2014-04-09 | 江南大学 | 一株合成耐高渗氨基甲酸乙酯水解酶的粪肠球菌及其应用 |
KR101595976B1 (ko) * | 2013-04-04 | 2016-02-19 | 서울대학교 산학협력단 | 황색포도알균에 특이적 항균 활성을 가지는 리신 융합 단백질 및 이의 용도 |
EP2904912A1 (en) * | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
ES2767294T3 (es) * | 2014-06-26 | 2020-06-17 | Univ Rockefeller | Lisinas de Acinetobacter |
PL229262B1 (pl) * | 2014-08-27 | 2018-06-29 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Polipeptyd zdolny do trawienia peptydoglikanu, jego zastosowania oraz kodujący go polinukleotyd |
CN104211781A (zh) * | 2014-09-04 | 2014-12-17 | 北京纳百景弈生物科技有限公司 | 金黄色葡萄球菌裂解蛋白的制备方法及其应用 |
US10634674B2 (en) * | 2015-04-08 | 2020-04-28 | Haesung Bio Co., Ltd. | Probe for detecting bacteria using peptidoglycan-binding protein, and use thereof |
CN104762285B (zh) * | 2015-04-23 | 2017-10-27 | 武汉菲吉乐科生物科技有限公司 | 一种自内裂解大肠杆菌的裂解酶及其应用 |
CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
CN105647893A (zh) * | 2016-03-04 | 2016-06-08 | 江南大学 | 一种D-丙氨酰-D-丙氨酸羧肽酶dacD基因及应用 |
CN105779485A (zh) * | 2016-04-08 | 2016-07-20 | 江南大学 | 一种基于dacB提高大肠杆菌重组蛋白胞外分泌水平的方法 |
CN105779484A (zh) * | 2016-04-08 | 2016-07-20 | 江南大学 | 一种基于dacD提高大肠杆菌重组蛋白胞外分泌水平的方法 |
CN105755029A (zh) * | 2016-04-08 | 2016-07-13 | 江南大学 | 一种基于dacA提高大肠杆菌重组蛋白胞外分泌水平的方法 |
WO2017196969A1 (en) * | 2016-05-12 | 2017-11-16 | Z Biotech, Llc | Multivalent glycan microarray platform |
CA3044121A1 (en) * | 2016-11-18 | 2018-05-24 | Lysando Ag | New antimicrobial agents against staphylococcus aureus |
CN106754849B (zh) * | 2017-03-13 | 2019-08-20 | 江苏省农业科学院 | 一种多功能裂解酶及其制备方法和应用 |
CN107058265B (zh) * | 2017-04-11 | 2020-08-28 | 天津科技大学 | 铜绿假单胞菌噬菌体裂解酶及应用 |
CN116603056A (zh) * | 2017-07-10 | 2023-08-18 | 康特拉费克特公司 | 裂解蛋白抗菌活性的血液组分强化及其方法和用途 |
CN108794613B (zh) * | 2018-05-03 | 2020-10-23 | 中国科学院南海海洋研究所 | 一种具有抑菌活性的香港牡蛎LysM蛋白及其编码基因和应用 |
US11959111B2 (en) | 2018-12-21 | 2024-04-16 | Novozymes A/S | Polypeptides having peptidoglycan degrading activity and polynucleotides encoding same |
CN111876400B (zh) * | 2020-08-06 | 2022-05-24 | 昆明理工大学 | 一种常温裂解酶Sly和编码此酶的多核苷酸 |
CN113234172B (zh) * | 2021-05-07 | 2022-04-22 | 宜昌市第一人民医院(三峡大学人民医院) | 一种梅毒特异抗体的检测探针及其制备方法 |
CN114315982B (zh) * | 2021-11-26 | 2022-09-27 | 暨南大学 | 一种新型噬菌体内溶素LysDLn1及其应用 |
CN114807106B (zh) * | 2022-04-25 | 2023-09-01 | 昆明市延安医院 | 一种裂解酶pEf51和穿孔素蛋白pEf191的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7516694A (en) | 1993-07-30 | 1995-02-28 | Affymax Technologies N.V. | Biotinylation of proteins |
DE19837751A1 (de) * | 1998-08-20 | 2000-02-24 | Siegfried Scherer | Markierung, Immobilisierung, Anreicherung, Reinigung und Nachweis von Zellen mittels der Verwendung spezifischer Zellwand-bindender Domänen (CBD) von Zellwand-bindenden Proteinen aus Viren, Bakterien oder eukaryontischen Zellen |
DE10129815A1 (de) | 2001-06-24 | 2003-01-09 | Profos Ag | Verfahren zur Aufreinigung von Bakterienzellen und Zellbestandteilen |
US20040197833A1 (en) | 2003-04-03 | 2004-10-07 | Danisco A/S | Method for the enrichment of target cells by use of CBDs |
CN101437532B (zh) * | 2006-05-05 | 2013-08-21 | 冈戈根股份有限公司 | 噬菌体衍生的抗微生物活性剂 |
DE102006061002A1 (de) | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
DK2511369T3 (da) * | 2007-08-22 | 2014-01-27 | Hyglos Invest Gmbh | Proteasestabile cellevægslyserende enzymer |
-
2008
- 2008-08-19 EP EP08162644A patent/EP2157100A1/en not_active Ceased
-
2009
- 2009-08-19 JP JP2011523419A patent/JP2012500015A/ja active Pending
- 2009-08-19 BR BRPI0918027A patent/BRPI0918027A2/pt not_active IP Right Cessation
- 2009-08-19 CA CA2734829A patent/CA2734829A1/en not_active Abandoned
- 2009-08-19 AU AU2009284175A patent/AU2009284175A1/en not_active Abandoned
- 2009-08-19 CN CN200980141348XA patent/CN102186878A/zh active Pending
- 2009-08-19 WO PCT/EP2009/060716 patent/WO2010020657A1/en active Application Filing
- 2009-08-19 US US13/059,956 patent/US20120244595A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN102186878A (zh) | 2011-09-14 |
EP2157100A1 (en) | 2010-02-24 |
AU2009284175A1 (en) | 2010-02-25 |
JP2012500015A (ja) | 2012-01-05 |
US20120244595A1 (en) | 2012-09-27 |
CA2734829A1 (en) | 2010-02-25 |
WO2010020657A1 (en) | 2010-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |