BRPI0908893A2 - Modulação enzimática e de receptores - Google Patents
Modulação enzimática e de receptoresInfo
- Publication number
- BRPI0908893A2 BRPI0908893A2 BRPI0908893-8A BRPI0908893A BRPI0908893A2 BR PI0908893 A2 BRPI0908893 A2 BR PI0908893A2 BR PI0908893 A BRPI0908893 A BR PI0908893A BR PI0908893 A2 BRPI0908893 A2 BR PI0908893A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- receptor modulation
- receptor
- modulation
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0803747.5A GB0803747D0 (en) | 2008-02-29 | 2008-02-29 | Enzyme and receptor modulation |
| PCT/GB2009/000561 WO2009106848A2 (en) | 2008-02-29 | 2009-02-27 | Enzyme and receptor modulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0908893A2 true BRPI0908893A2 (pt) | 2015-08-25 |
Family
ID=39315698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908893-8A BRPI0908893A2 (pt) | 2008-02-29 | 2009-02-27 | Modulação enzimática e de receptores |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20100317865A1 (pt) |
| EP (1) | EP2252328A2 (pt) |
| JP (1) | JP2011513289A (pt) |
| KR (2) | KR20100126762A (pt) |
| CN (1) | CN101959534B (pt) |
| AU (1) | AU2009219926B2 (pt) |
| BR (1) | BRPI0908893A2 (pt) |
| CA (2) | CA2934402C (pt) |
| EA (1) | EA019838B1 (pt) |
| GB (1) | GB0803747D0 (pt) |
| IL (1) | IL207537A (pt) |
| MX (1) | MX2010009341A (pt) |
| NZ (1) | NZ587341A (pt) |
| WO (1) | WO2009106848A2 (pt) |
| ZA (1) | ZA201006071B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007017228A (ja) * | 2005-07-06 | 2007-01-25 | Cti Science System Co Ltd | 河床高測定装置および河床高測定方法 |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
| GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
| WO2012025701A1 (en) * | 2010-08-25 | 2012-03-01 | Chroma Therapeutics Ltd. | Alpha, alpha - di substituted glycine ester derivatives and their use as hdac inhibitors |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| EP2909175B1 (en) | 2012-10-17 | 2017-06-07 | Macrophage Pharma Limited | Tert-butyl n-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2h)-yl]-3,5- difluorophenyl}ethyl]-l-alaninate or a salt, hydrate or solvate thereof |
| WO2017216297A1 (en) | 2016-06-16 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Dosage regimen |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
| CN115896065B (zh) * | 2022-09-06 | 2023-08-11 | 江南大学 | 一种立体选择性羧酯酶、编码基因、载体及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5331006A (en) * | 1990-08-31 | 1994-07-19 | Warner-Lambert Company | Amino acid analogs as CCK antagonists |
| JPH08151364A (ja) * | 1994-02-18 | 1996-06-11 | Nissan Chem Ind Ltd | 含窒素環状化合物および除草剤 |
| BR9505995A (pt) * | 1994-12-23 | 1997-12-23 | Pfizer | Composto método para tratamentos e composição farmacêutica |
| JP2000198735A (ja) * | 1998-10-28 | 2000-07-18 | Takeda Chem Ind Ltd | 縮合ピリダジン誘導体を含有してなる医薬 |
| JP2003171381A (ja) * | 2001-09-25 | 2003-06-20 | Takeda Chem Ind Ltd | エントリー阻害剤 |
| AU2003223953A1 (en) | 2002-03-14 | 2003-09-22 | Bayer Healthcare Ag | Monocyclic aroylpyridinones as antiinflammatory agents |
| EP1633751A1 (en) * | 2003-06-16 | 2006-03-15 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
| CA2533966A1 (en) * | 2003-07-30 | 2005-02-10 | Gilead Sciences, Inc. | Nucleobase phosphonate analogs for antiviral treatment |
| ES2299080T3 (es) * | 2004-05-14 | 2008-05-16 | Millennium Pharmaceuticals, Inc. | Compuestos y metodos para inhibir la progresion mitotica mediante la inhibicion de quinasas aurora. |
| SI1905773T1 (sl) * | 2004-05-14 | 2013-01-31 | Millennium Pharmaceuticals, Inc. | Spojine in postopki za inhibiranje mitotične progresije z inhibiranjem aurora kinaze |
| GB0509225D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| EP3530290A1 (en) | 2005-05-05 | 2019-08-28 | GlaxoSmithKline Intellectual Property Development Limited | Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase |
| GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0608837D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | Inhibitors of MAP kinase |
| GB0608821D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | DHFR enzyme inhibitors |
| GB0608823D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | Inhibitors of P13 kinase |
| CN102942520B (zh) | 2006-05-04 | 2015-03-04 | 色品疗法有限公司 | p38 MAP激酶抑制剂 |
| SG174029A1 (en) * | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminoalcohol derivative and immunosuppressant containing the same as active ingredient |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| GB0621203D0 (en) | 2006-10-25 | 2006-12-06 | Chroma Therapeutics Ltd | PLK inhibitors |
| KR20090071668A (ko) | 2006-10-25 | 2009-07-01 | 크로마 데러퓨릭스 리미티드 | 암치료에 유용한 폴로형 키나아제 억제제로서 프테리딘 유도체 |
| JP2010507648A (ja) * | 2006-10-25 | 2010-03-11 | ラモット アット テル−アビブ ユニバーシティー リミテッド | グルタミン酸ｎｍｄａ活性を有する新規向精神薬 |
| EP2077999B1 (en) | 2006-10-30 | 2014-07-30 | Chroma Therapeutics Limited | Hydroxamates as inhibitors of histone deacetylase |
| JP2010508337A (ja) | 2006-11-01 | 2010-03-18 | クロマ セラピューティクス リミテッド | Ｉｋｋ−ベータセリン−スレオニンプロテインキナーゼの阻害剤 |
| NZ576705A (en) | 2006-11-01 | 2011-12-22 | Chroma Therapeutics Ltd | IKK-Beta SERINE-THREONINE PROTEIN KINASE INHIBITORS |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| EP2190852A1 (en) * | 2007-08-15 | 2010-06-02 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| WO2009060160A1 (en) | 2007-11-07 | 2009-05-14 | Chroma Therapeutics Ltd. | P38 map kinase inhibitors |
| JP5555186B2 (ja) * | 2008-02-29 | 2014-07-23 | クロマ セラピューティクス リミテッド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| GB0807451D0 (en) * | 2008-04-24 | 2008-05-28 | Chroma Therapeutics Ltd | Inhibitors of PLK |
| GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
-
2008
- 2008-02-29 GB GBGB0803747.5A patent/GB0803747D0/en not_active Ceased
-
2009
- 2009-02-27 NZ NZ587341A patent/NZ587341A/en not_active IP Right Cessation
- 2009-02-27 MX MX2010009341A patent/MX2010009341A/es active IP Right Grant
- 2009-02-27 CN CN2009801069800A patent/CN101959534B/zh not_active Expired - Fee Related
- 2009-02-27 US US12/867,455 patent/US20100317865A1/en not_active Abandoned
- 2009-02-27 KR KR1020107021372A patent/KR20100126762A/ko not_active Application Discontinuation
- 2009-02-27 WO PCT/GB2009/000561 patent/WO2009106848A2/en active Application Filing
- 2009-02-27 CA CA2934402A patent/CA2934402C/en active Active
- 2009-02-27 EP EP09714148A patent/EP2252328A2/en not_active Ceased
- 2009-02-27 AU AU2009219926A patent/AU2009219926B2/en not_active Ceased
- 2009-02-27 EA EA201001390A patent/EA019838B1/ru not_active IP Right Cessation
- 2009-02-27 BR BRPI0908893-8A patent/BRPI0908893A2/pt not_active Application Discontinuation
- 2009-02-27 CA CA2717020A patent/CA2717020C/en active Active
- 2009-02-27 JP JP2010548178A patent/JP2011513289A/ja active Pending
- 2009-02-27 KR KR1020167016080A patent/KR20160074017A/ko not_active Application Discontinuation
-
2010
- 2010-08-11 IL IL207537A patent/IL207537A/en active IP Right Grant
- 2010-08-25 ZA ZA2010/06071A patent/ZA201006071B/en unknown
-
2013
- 2013-11-27 US US14/091,522 patent/US20140088159A1/en not_active Abandoned
-
2016
- 2016-02-08 US US15/017,853 patent/US9636409B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2252328A2 (en) | 2010-11-24 |
| MX2010009341A (es) | 2010-09-24 |
| US20160151509A1 (en) | 2016-06-02 |
| CN101959534A (zh) | 2011-01-26 |
| AU2009219926B2 (en) | 2014-04-17 |
| IL207537A0 (en) | 2010-12-30 |
| EA201001390A1 (ru) | 2011-06-30 |
| EA019838B1 (ru) | 2014-06-30 |
| KR20100126762A (ko) | 2010-12-02 |
| US20100317865A1 (en) | 2010-12-16 |
| US9636409B2 (en) | 2017-05-02 |
| IL207537A (en) | 2016-10-31 |
| WO2009106848A2 (en) | 2009-09-03 |
| US20140088159A1 (en) | 2014-03-27 |
| AU2009219926A1 (en) | 2009-09-03 |
| ZA201006071B (en) | 2011-05-25 |
| JP2011513289A (ja) | 2011-04-28 |
| GB0803747D0 (en) | 2008-04-09 |
| CA2717020A1 (en) | 2009-09-03 |
| CN101959534B (zh) | 2013-11-27 |
| CA2934402C (en) | 2020-04-21 |
| CA2717020C (en) | 2016-06-28 |
| KR20160074017A (ko) | 2016-06-27 |
| WO2009106848A3 (en) | 2010-05-14 |
| NZ587341A (en) | 2012-07-27 |
| CA2934402A1 (en) | 2009-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/4418 (2006.01), A61K 47/54 (2017.01), C07D |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: CRT PIONEER FUD LP (GB) |
|
| B25A | Requested transfer of rights approved |
Owner name: MACROPHAGE PHARMA LIMITED (GB) |
|
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |