BRPI0917503B8 - composição de ferro férrico para uso em um método de tratamento de hiperfosfatemia, bem como fluido de diálise e método ex vivo para remoção de fosfato de meio - Google Patents

composição de ferro férrico para uso em um método de tratamento de hiperfosfatemia, bem como fluido de diálise e método ex vivo para remoção de fosfato de meio

Info

Publication number
BRPI0917503B8
BRPI0917503B8 BRPI0917503A BRPI0917503A BRPI0917503B8 BR PI0917503 B8 BRPI0917503 B8 BR PI0917503B8 BR PI0917503 A BRPI0917503 A BR PI0917503A BR PI0917503 A BRPI0917503 A BR PI0917503A BR PI0917503 B8 BRPI0917503 B8 BR PI0917503B8
Authority
BR
Brazil
Prior art keywords
ferric iron
medium
well
dialysis fluid
iron composition
Prior art date
Application number
BRPI0917503A
Other languages
English (en)
Inventor
Joseph Powell Jonathan
Jorge Rodrigues Faria Nuno
Original Assignee
Medical Res Council
Res & Innovation Uk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council, Res & Innovation Uk filed Critical Medical Res Council
Publication of BRPI0917503A2 publication Critical patent/BRPI0917503A2/pt
Publication of BRPI0917503B1 publication Critical patent/BRPI0917503B1/pt
Publication of BRPI0917503B8 publication Critical patent/BRPI0917503B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
    • A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/015—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

materiais de ligação ao fosfato e seus usos são apresentados materiais de ligação ao fosfato e composições compreendendo os mesmos, os quais são materiais iônicos metálicos polioxo-hidróxi modificados por ligante sólido, tendo como base oxo-hidróxidos de ferro férrico modificados com ligantes de ácido carboxílico, ou formas ionizadas do mesmo. esses materiais são produzidos e testados nos exemplos fornecidos no pedido a fim de demonstrar que podem ligar-se ao fosfato em testes in vitro e in vivo.
BRPI0917503A 2008-08-05 2009-08-05 composição de ferro férrico para uso em um método de tratamento de hiperfosfatemia, bem como fluido de diálise e método ex vivo para remoção de fosfato de meio BRPI0917503B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8624408P 2008-08-05 2008-08-05
US61/086.244 2008-08-05
GB08143265 2008-08-05
GBGB0814326.5A GB0814326D0 (en) 2008-08-05 2008-08-05 Phosphate binding materials and their uses
PCT/GB2009/001931 WO2010015827A2 (en) 2008-08-05 2009-08-05 Phosphate binding materials and their uses

Publications (3)

Publication Number Publication Date
BRPI0917503A2 BRPI0917503A2 (pt) 2015-11-17
BRPI0917503B1 BRPI0917503B1 (pt) 2021-01-05
BRPI0917503B8 true BRPI0917503B8 (pt) 2021-05-25

Family

ID=39767560

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0917503A BRPI0917503B8 (pt) 2008-08-05 2009-08-05 composição de ferro férrico para uso em um método de tratamento de hiperfosfatemia, bem como fluido de diálise e método ex vivo para remoção de fosfato de meio

Country Status (21)

Country Link
US (1) US7943664B2 (pt)
EP (1) EP2320884B1 (pt)
JP (2) JP5805532B2 (pt)
KR (1) KR101653423B1 (pt)
CN (1) CN102143742B (pt)
AU (1) AU2009278906B9 (pt)
BR (1) BRPI0917503B8 (pt)
CA (1) CA2732226C (pt)
EA (1) EA021705B1 (pt)
ES (1) ES2592315T3 (pt)
GB (2) GB0814326D0 (pt)
HU (1) HUE029874T2 (pt)
IL (1) IL210913A (pt)
LT (1) LT2320884T (pt)
MX (1) MX2011001258A (pt)
PL (1) PL2320884T3 (pt)
PT (1) PT2320884T (pt)
SI (1) SI2320884T1 (pt)
SM (1) SMT201600359B (pt)
WO (1) WO2010015827A2 (pt)
ZA (1) ZA201100821B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008212653B2 (en) * 2007-02-06 2012-05-24 United Kingdom Research And Innovation Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
TWI468167B (zh) 2007-11-16 2015-01-11 威佛（國際）股份有限公司 藥學組成物
JP2013520647A (ja) * 2010-02-19 2013-06-06 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ クロマトグラフィー媒体の製造方法
GB201101299D0 (en) 2011-01-25 2011-03-09 Medical Res Council Oxygen sensors and their uses
WO2013027214A2 (en) 2011-08-22 2013-02-28 Bar-Ilan University Nanop article dialysis
US9370202B2 (en) 2013-03-15 2016-06-21 LG Bionano, LLC Encapsulated metal ion nanoclusters
RS60894B1 (sr) 2013-11-27 2020-11-30 Vifor Int Ag Farmaceutska kompozicija, koja sadrži čestice vezivnog sredstva za fosfat
EP3191219A1 (en) * 2014-09-10 2017-07-19 Lupin Limited A manufacturing process for an iron containing adsorbent
GB201517893D0 (en) * 2015-10-09 2015-11-25 Medical Res Council Methods for producing carboxylate ligand modified ferric iron hydroxide colloids
WO2017145151A1 (en) * 2016-02-23 2017-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (nr) and cosmetic composition comprising (nr and a phosphate-binding agent
US11136251B2 (en) 2017-03-23 2021-10-05 Regents Of The University Of Minnesota Compositions, methods, and devices for capturing phosphate from water
CN114797781B (zh) * 2022-06-07 2022-12-06 广东粤海水务投资有限公司 一种载镧氮掺杂多孔碳磷吸附材料的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT279048B (de) * 1967-07-04 1970-02-25 Pharmazeutische Fabrik Montavit Gmbh Verfahren zur Herstellung neuer, löslicher und stabiler organischer Eisen(III)-Komplexverbindungen und Injektionslösungen davon
DE4239442C2 (de) * 1992-11-24 2001-09-13 Sebo Gmbh Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten
DE19547356A1 (de) * 1995-12-19 1997-06-26 Vifor Int Ag Adsorbens für Phosphat aus wäßrigem Medium, dessen Herstellung und Verwendung
TWI335218B (en) * 2003-02-19 2011-01-01 Panion & Bf Biotech Inc Ferric organic compounds, uses thereof and methods of making same
US6903235B2 (en) 2003-10-08 2005-06-07 Panion & Bf Biotech Inc. Pharmaceutical-grade ferric citrate
MY157620A (en) 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
PT2319804E (pt) 2006-12-14 2014-11-24 Novartis Ag Adsorvente de fosfato à base de ferro (iii)-carboidrato
AU2008212653B2 (en) 2007-02-06 2012-05-24 United Kingdom Research And Innovation Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
GB0702270D0 (en) * 2007-02-06 2007-03-14 Medical Res Council Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
TWI468167B (zh) * 2007-11-16 2015-01-11 威佛（國際）股份有限公司 藥學組成物

Also Published As

Publication number Publication date
CN102143742B (zh) 2015-05-13
JP5805532B2 (ja) 2015-11-04
HUE029874T2 (en) 2017-04-28
EA201170116A1 (ru) 2011-08-30
SI2320884T1 (sl) 2016-11-30
GB2462374B (en) 2010-12-22
WO2010015827A3 (en) 2010-04-01
ES2592315T3 (es) 2016-11-29
CA2732226A1 (en) 2010-02-11
AU2009278906A1 (en) 2010-02-11
WO2010015827A2 (en) 2010-02-11
EP2320884A2 (en) 2011-05-18
US20100032374A1 (en) 2010-02-11
SMT201600359B (it) 2016-11-10
JP2011529954A (ja) 2011-12-15
ZA201100821B (en) 2011-09-28
GB0814326D0 (en) 2008-09-10
AU2009278906B2 (en) 2014-11-13
EA021705B1 (ru) 2015-08-31
IL210913A0 (en) 2011-04-28
CA2732226C (en) 2017-09-12
KR101653423B1 (ko) 2016-09-01
PL2320884T3 (pl) 2017-01-31
JP2014205689A (ja) 2014-10-30
US7943664B2 (en) 2011-05-17
AU2009278906B9 (en) 2015-04-02
BRPI0917503B1 (pt) 2021-01-05
CN102143742A (zh) 2011-08-03
GB2462374A (en) 2010-02-10
PT2320884T (pt) 2016-09-22
GB0913684D0 (en) 2009-09-16
KR20110052680A (ko) 2011-05-18
MX2011001258A (es) 2011-04-04
LT2320884T (lt) 2016-10-10
EP2320884B1 (en) 2016-07-13
IL210913A (en) 2014-07-31
BRPI0917503A2 (pt) 2015-11-17

Similar Documents

Publication Publication Date Title
BRPI0917503B8 (pt) composição de ferro férrico para uso em um método de tratamento de hiperfosfatemia, bem como fluido de diálise e método ex vivo para remoção de fosfato de meio
BR112012019693A2 (pt) anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles.
BRPI1013688A8 (pt) Proteínas de ligação de il-17.
WO2016100976A3 (en) Methods for identifying multiple epitopes in selected sub-populations of cells
CL2016002340A1 (es) Proteínas de unión al antígeno cd27l; ácido nucleico que la codifica; vector de expresión; célula huésped recombinante; composición que la comprende; su uso para tratar cáncer, trastornos autoinmunitarios o inflamatorios; y método para elaborar un conjugado anticuerpo cd27l-fármaco (divisional sol. n° 699-14).
WO2006117596A3 (en) Nucleic acid probes and nucleic acid analog probes
EA201000146A1 (ru) Связующее майларда на основе гидроксимонокарбоновой кислоты
BR112012033091A2 (pt) método de cimentação, e, composição de cimento
BRPI0519897A2 (pt) método para modular a atividade ou atividades biológicas de moléculas alvo em uma célula alvo, agente de ligação biespecìfico, composição, uso de um agente de ligação biespecìfico, e, kit
AR066395A1 (es) Reovirus que tienen secuencias modificadas
BRPI0918670B8 (pt) anticorpo
BRPI0907663A2 (pt) ''composição que compreende hfo- 123 yf, composição que compreende hcfc-243db, composição que compreende hcfo- 1233xf, composição que comproeende hcfc- 244bb, uso das composições e método de uso das composições.
AR060583A1 (es) Anticuerpo de c- kit humanizado
AR069980A1 (es) Inmunoconjugados dirigidos contra cd 138 y sus usos
BR112014012121A2 (pt) proteínas ligantes
BRPI0906478B8 (pt) anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende
BRPI0807132A2 (pt) enzimas para o tratamento de lignocelulósicos, ácidos nucléicos que codificam as mesmas, e metodos e uso das mesmas
BR112013014238A2 (pt) processo para tratar uma formação subterrânea, fluido adequado para uso no processo e sal de amônio da fórmula mx(nh4)yhz-glda ou da fórmula mx(nh4)yhz-mgda
AR088513A1 (es) Inmunoenlazantes dirigidos contra esclerostina
BRPI0814343A2 (pt) Materiais e métodos para a seleção da sexagem do esperma
CO6351748A2 (es) Anticuerpos contra il-6 y sus usos
GB201020995D0 (en) Biological materials and uses thereof
BR112013003825A2 (pt) conjugados, partículas, composições e métodos relacionados
AR064301A1 (es) Absorbente de fosfato basado en hierro (iii)
NI201000055A (es) 2' - fluoro - 2' - desoxitetrahidrouridinas como inhibidores de citidina desaminasa.

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 31/26 (2006.01), A23L 5/20 (2016.01), A23L 29

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B25A Requested transfer of rights approved

Owner name: UNITED KINGDOM RESEARCH AND INNOVATION (GB)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/08/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF