BRPI0909282A2 - Conversão de triptofano em derivados de beta-carbolina - Google Patents

Conversão de triptofano em derivados de beta-carbolina

Info

Publication number
BRPI0909282A2
BRPI0909282A2 BRPI0909282-0A BRPI0909282A BRPI0909282A2 BR PI0909282 A2 BRPI0909282 A2 BR PI0909282A2 BR PI0909282 A BRPI0909282 A BR PI0909282A BR PI0909282 A2 BRPI0909282 A2 BR PI0909282A2
Authority
BR
Brazil
Prior art keywords
tryptophan
beta
conversion
carboline derivatives
carboline
Prior art date
Application number
BRPI0909282-0A
Other languages
English (en)
Inventor
Samo Pirc
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of BRPI0909282A2 publication Critical patent/BRPI0909282A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
BRPI0909282-0A 2008-03-31 2009-03-26 Conversão de triptofano em derivados de beta-carbolina BRPI0909282A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153750A EP2107059A1 (en) 2008-03-31 2008-03-31 Conversion of tryptophan into ß-carboline derivatives
PCT/EP2009/053588 WO2009121791A1 (en) 2008-03-31 2009-03-26 CONVERSION OF TRYPTOPHAN INTO ß-CARBOLINE DERIVATIVES

Publications (1)

Publication Number Publication Date
BRPI0909282A2 true BRPI0909282A2 (pt) 2015-08-04

Family

ID=40497568

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909282-0A BRPI0909282A2 (pt) 2008-03-31 2009-03-26 Conversão de triptofano em derivados de beta-carbolina

Country Status (11)

Country Link
US (1) US20110105751A1 (pt)
EP (2) EP2107059A1 (pt)
JP (1) JP2011516449A (pt)
CN (1) CN102036986A (pt)
AU (1) AU2009231426A1 (pt)
BR (1) BRPI0909282A2 (pt)
CA (1) CA2719526A1 (pt)
MX (1) MX2010010774A (pt)
RU (1) RU2010144309A (pt)
WO (1) WO2009121791A1 (pt)
ZA (1) ZA201006854B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2541421T3 (es) * 2011-02-10 2015-07-20 Interquim, S.A. Procedimiento de obtención de compuestos derivados de tetrahidro-ß-carbolina
CN102796098B (zh) * 2011-05-27 2014-04-16 首都医科大学 (1S,3S)-1-亚甲二氧基苯-1,2,3,4-四氢-β-咔啉-3-甲酰氨基酸甲酯、其制备方法和应用
CN104876930B (zh) * 2014-02-27 2017-08-01 人福医药集团股份公司 合成制备化合物的方法
CN110606847A (zh) * 2019-07-30 2019-12-24 中国医药集团总公司四川抗菌素工业研究所 一种他达拉非顺式中间体的制备方法及其应用
CN111116583A (zh) * 2019-12-23 2020-05-08 平光制药股份有限公司 一种他达拉非中间体的制备方法
CN111253399A (zh) * 2020-03-30 2020-06-09 苏州弘森药业股份有限公司 一种他达拉非原料药的生产工艺
CN114805345B (zh) * 2022-04-27 2023-11-10 山东省药学科学院 一种他达拉非中间体顺式四氢咔啉盐酸盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
JP4163453B2 (ja) * 2002-06-04 2008-10-08 日野自動車株式会社 インジェクションパイプの組付構造
KR100937915B1 (ko) 2002-07-31 2010-01-21 릴리 아이코스 엘엘씨 변형된 픽텟-스펭글러 반응 및 그것으로부터 제조된생성물
WO2005068464A2 (en) 2003-12-15 2005-07-28 Cadila Healthcare Limited Process for preparing tadalafil and its intermediates
MX2007012607A (es) 2005-04-12 2008-01-11 Teva Pharma Preparacion de intermedios de tadalafil.
WO2007052283A1 (en) 2005-10-31 2007-05-10 Alembic Limited An improved process for preparing tadalafil and its intermediate
WO2007100387A2 (en) 2005-11-03 2007-09-07 Dr. Reddy's Laboratories Ltd. Process for preparing tadalafil

Also Published As

Publication number Publication date
ZA201006854B (en) 2011-06-29
AU2009231426A1 (en) 2009-10-08
MX2010010774A (es) 2010-11-01
CN102036986A (zh) 2011-04-27
RU2010144309A (ru) 2012-05-10
EP2279186A1 (en) 2011-02-02
WO2009121791A1 (en) 2009-10-08
CA2719526A1 (en) 2009-10-08
EP2107059A1 (en) 2009-10-07
JP2011516449A (ja) 2011-05-26
US20110105751A1 (en) 2011-05-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.