BRPI0906972A2 - Composições de matriz extracelular. - Google Patents
Composições de matriz extracelular.Info
- Publication number
- BRPI0906972A2 BRPI0906972A2 BRPI0906972-0A BRPI0906972A BRPI0906972A2 BR PI0906972 A2 BRPI0906972 A2 BR PI0906972A2 BR PI0906972 A BRPI0906972 A BR PI0906972A BR PI0906972 A2 BRPI0906972 A2 BR PI0906972A2
- Authority
- BR
- Brazil
- Prior art keywords
- extracellular matrix
- matrix compositions
- compositions
- extracellular
- matrix
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Developmental Biology & Embryology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2485408P | 2008-01-30 | 2008-01-30 | |
US61/024,854 | 2008-01-30 | ||
US3436108P | 2008-03-06 | 2008-03-06 | |
US61/034,361 | 2008-03-06 | ||
US5094008P | 2008-05-06 | 2008-05-06 | |
US61/050,940 | 2008-05-06 | ||
PCT/US2009/032697 WO2009097559A1 (en) | 2008-01-30 | 2009-01-30 | Extracellular matrix compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0906972A2 true BRPI0906972A2 (pt) | 2015-07-14 |
BRPI0906972B1 BRPI0906972B1 (pt) | 2021-09-08 |
Family
ID=40913280
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0906972-0A BRPI0906972B1 (pt) | 2008-01-30 | 2009-01-30 | Métodos para produção de composições de matriz extracelular e para produção de uma proteína wnt e de um fator de crescimento endotelial vascular |
BR122020017131-6A BR122020017131B1 (pt) | 2008-01-30 | 2009-01-30 | Métodos de produção de composição para reparo e/ou regeneração de células, para auxiliar no crescimento de células-tronco, para modificar a cicatrização de ferida, a inflamação, uma formação de cápsula fibrosa, o crescimento tecidual ou modificar o crescimento celular, para aperfeiçoamento de uma superfície cutânea, para reparo ou aumento de tecido mole, e de promoção do crescimento capilar |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122020017131-6A BR122020017131B1 (pt) | 2008-01-30 | 2009-01-30 | Métodos de produção de composição para reparo e/ou regeneração de células, para auxiliar no crescimento de células-tronco, para modificar a cicatrização de ferida, a inflamação, uma formação de cápsula fibrosa, o crescimento tecidual ou modificar o crescimento celular, para aperfeiçoamento de uma superfície cutânea, para reparo ou aumento de tecido mole, e de promoção do crescimento capilar |
Country Status (12)
Country | Link |
---|---|
US (1) | US8257947B2 (pt) |
EP (1) | EP2262891B1 (pt) |
JP (2) | JP5647007B2 (pt) |
KR (1) | KR101650957B1 (pt) |
CN (1) | CN102066558B (pt) |
AP (1) | AP3129A (pt) |
AU (1) | AU2009209022B2 (pt) |
BR (2) | BRPI0906972B1 (pt) |
CA (1) | CA2714387C (pt) |
SG (2) | SG10201500237TA (pt) |
WO (1) | WO2009097559A1 (pt) |
ZA (1) | ZA201006148B (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008109407A2 (en) | 2007-03-02 | 2008-09-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix-derived gels and related methods |
US9283302B2 (en) | 2011-12-16 | 2016-03-15 | Cormatrix Cardiovascular, Inc. | Extracellular matrix encasement structures and methods |
US8524494B2 (en) * | 2008-01-30 | 2013-09-03 | Histogen, Inc. | Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro |
US9290740B2 (en) * | 2008-03-07 | 2016-03-22 | Worcester Polytechnic Institute | Use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells |
EP2451964B1 (en) * | 2009-07-10 | 2018-01-24 | Histogen, Inc. | Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions |
RU2418066C1 (ru) * | 2010-04-26 | 2011-05-10 | Учреждение Российской академии наук Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук (ГНЦ РФ-ИМБП РАН) | Способ модификации пролиферативной активности и дифференцировочной потенции мультипотентных мезенхимальных стромальных клеток |
WO2012018680A1 (en) * | 2010-07-31 | 2012-02-09 | Global Therapeutics Llc | Methods and systems for generating a tissue pocket in a patient |
CA2887350A1 (en) * | 2012-10-08 | 2014-04-17 | Cormatrix Cardiovascular, Inc. | Method and system for treating biological tissue |
ES2701006T3 (es) * | 2013-02-12 | 2019-02-20 | Replicel Life Sciences Inc | Composiciones y métodos para tratar y reparar tendones |
WO2014171746A1 (ko) * | 2013-04-19 | 2014-10-23 | 고려대학교산학협력단 | 신경줄기세포 추출물을 함유하는 발모촉진 또는 탈모방지용 조성물 및 이의 제조방법 |
US10533191B2 (en) | 2014-01-15 | 2020-01-14 | Serucell Corporation | Therapeutic serum obtained from co-cultured cells |
WO2015123477A1 (en) | 2014-02-12 | 2015-08-20 | Replicel Life Sciences Inc. | Compositions and methods for treating bone, joints and cartilage |
ES2806505T3 (es) | 2014-03-21 | 2021-02-17 | Univ Pittsburgh Commonwealth Sys Higher Education | Procedimientos de preparación de un hidrogel esterilizado de modo terminal que proviene de matriz extracelular |
WO2015152596A1 (ko) * | 2014-03-31 | 2015-10-08 | 아주대학교산학협력단 | 표면개질된 연골세포 유래 세포외 기질막을 유효성분으로 함유하는 유착방지용 조성물 |
KR101633585B1 (ko) * | 2014-03-31 | 2016-06-27 | 아주대학교산학협력단 | 표면개질된 연골세포 유래 세포외 기질막을 유효성분으로 함유하는 유착방지용 조성물 |
WO2015164728A1 (en) * | 2014-04-24 | 2015-10-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Fractionating extracellular matrix to modulate bioactivity and the host response |
JP6718202B2 (ja) * | 2014-06-20 | 2020-07-08 | 共栄化学工業株式会社 | 皮膚外用剤 |
FR3029116B1 (fr) | 2014-12-01 | 2018-03-30 | Advanced Chitosan Solutions Biotech | Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes |
FR3032632A1 (fr) * | 2015-02-12 | 2016-08-19 | Exel Ind | Pistolet de projection d'un fluide, filtre pour un tel pistolet, et procede d'extraction d'un filtre hors d'un tel pistolet |
CN104941008A (zh) * | 2015-05-19 | 2015-09-30 | 烟台正海生物科技股份有限公司 | 一种引导组织再生膜的制备方法及其应用 |
CN105769381B (zh) * | 2015-05-26 | 2018-04-17 | 南通大学 | 一种用于组织损伤修复的生物补片 |
JP6587877B2 (ja) * | 2015-09-17 | 2019-10-09 | 日本メナード化粧品株式会社 | 表皮幹細胞を分離するためのマーカー及び三次元培養表皮の製造方法 |
CN106978394B (zh) * | 2017-02-23 | 2020-06-23 | 北京恒峰铭成生物科技有限公司 | 一种抗慢性炎症的间充质干细胞的制备方法及其应用 |
US11291688B2 (en) | 2017-03-02 | 2022-04-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Extracellular matrix (ECM) hydrogel and soluble fraction thereof for the treatment of cancer |
US11718829B2 (en) * | 2017-07-28 | 2023-08-08 | Breakthrough Tech Llc | Methods and compositions for manufacturing extracellular matrix |
JP7151203B2 (ja) * | 2018-06-19 | 2022-10-12 | 東洋インキScホールディングス株式会社 | 細胞培養培地添加剤、細胞培養培地及び細胞凝集塊の製造方法 |
WO2020028526A1 (en) * | 2018-08-02 | 2020-02-06 | Histogen, Inc. | Conditioned medium and extracellular matrix compositions and uses thereof |
CN112334144A (zh) | 2018-08-03 | 2021-02-05 | 株式会社细胞应用技术研究所 | 培养上清液制剂的制造方法 |
CN110607279B (zh) * | 2019-10-18 | 2023-09-19 | 深圳优圣康医学检验实验室 | 一种原代肿瘤细胞的3d培养体系及其培养方法和应用 |
US20210254008A1 (en) * | 2020-02-14 | 2021-08-19 | Allergan Sales, Llc | Conditioned medium from cells cultured under hypoxic conditions and uses thereof |
WO2023167082A1 (ja) * | 2022-03-01 | 2023-09-07 | 国立大学法人横浜国立大学 | 増幅毛包間葉系細胞の製造方法及びその使用 |
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2009
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- 2009-01-30 CN CN200980110464.5A patent/CN102066558B/zh active Active
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- 2009-01-30 KR KR1020107019322A patent/KR101650957B1/ko active IP Right Grant
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- 2009-01-30 BR BRPI0906972-0A patent/BRPI0906972B1/pt active IP Right Grant
- 2009-01-30 BR BR122020017131-6A patent/BR122020017131B1/pt active IP Right Grant
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BRPI0906972B1 (pt) | 2021-09-08 |
AP2010005380A0 (en) | 2010-08-31 |
KR101650957B1 (ko) | 2016-08-24 |
SG10201906494PA (en) | 2019-09-27 |
US20100047305A1 (en) | 2010-02-25 |
CN102066558A (zh) | 2011-05-18 |
AP3129A (en) | 2015-02-28 |
SG10201500237TA (en) | 2015-04-29 |
AU2009209022B2 (en) | 2014-06-12 |
CA2714387C (en) | 2018-06-19 |
WO2009097559A1 (en) | 2009-08-06 |
CA2714387A1 (en) | 2009-08-06 |
BR122020017131B1 (pt) | 2023-05-16 |
KR20110011599A (ko) | 2011-02-08 |
JP5647007B2 (ja) | 2014-12-24 |
CN102066558B (zh) | 2017-02-08 |
JP2011510662A (ja) | 2011-04-07 |
JP2014221070A (ja) | 2014-11-27 |
ZA201006148B (en) | 2011-10-26 |
AU2009209022A1 (en) | 2009-08-06 |
EP2262891B1 (en) | 2022-09-21 |
US8257947B2 (en) | 2012-09-04 |
EP2262891A4 (en) | 2011-04-20 |
EP2262891A1 (en) | 2010-12-22 |
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