BRPI0821145A2 - Agente terapêutico para prurido - Google Patents

Agente terapêutico para prurido

Info

Publication number
BRPI0821145A2
BRPI0821145A2 BRPI0821145-0A BRPI0821145A BRPI0821145A2 BR PI0821145 A2 BRPI0821145 A2 BR PI0821145A2 BR PI0821145 A BRPI0821145 A BR PI0821145A BR PI0821145 A2 BRPI0821145 A2 BR PI0821145A2
Authority
BR
Brazil
Prior art keywords
itching
therapeutic agent
therapeutic
agent
itching therapeutic
Prior art date
Application number
BRPI0821145-0A
Other languages
English (en)
Inventor
Yoshinobu Higuchi
Keiko Kasutani
Hidetomo Kitamura
Masakazu Hasegawa
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0821145A2 publication Critical patent/BRPI0821145A2/pt
Publication of BRPI0821145B1 publication Critical patent/BRPI0821145B1/pt
Publication of BRPI0821145B8 publication Critical patent/BRPI0821145B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
BRPI0821145A 2007-12-05 2008-12-05 uso de um anticorpo anti-nr10 como agente preventivo ou terapêutico para prurido BRPI0821145B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007315144 2007-12-05
JP2007-315144 2007-12-05
PCT/JP2008/072142 WO2009072598A1 (ja) 2007-12-05 2008-12-05 掻痒症治療剤

Publications (3)

Publication Number Publication Date
BRPI0821145A2 true BRPI0821145A2 (pt) 2015-06-16
BRPI0821145B1 BRPI0821145B1 (pt) 2019-10-15
BRPI0821145B8 BRPI0821145B8 (pt) 2021-05-25

Family

ID=40717776

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821145A BRPI0821145B8 (pt) 2007-12-05 2008-12-05 uso de um anticorpo anti-nr10 como agente preventivo ou terapêutico para prurido

Country Status (14)

Country Link
US (1) US8431127B2 (pt)
EP (1) EP2241332A4 (pt)
JP (1) JP5475460B2 (pt)
KR (1) KR101595134B1 (pt)
CN (2) CN104162155A (pt)
AU (1) AU2008332276B2 (pt)
BR (1) BRPI0821145B8 (pt)
CA (1) CA2708065C (pt)
HK (2) HK1151226A1 (pt)
MX (1) MX2010006097A (pt)
MY (2) MY185647A (pt)
RU (2) RU2541780C2 (pt)
TW (1) TWI441649B (pt)
WO (1) WO2009072598A1 (pt)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10253091B2 (en) 2009-03-19 2019-04-09 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US10544227B2 (en) 2015-04-14 2020-01-28 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US11260125B2 (en) 2019-11-20 2022-03-01 Chugai Seiyaku Kabushiki Kaisha Anti-IL31RA antibody-containing formulations
US11332533B2 (en) 2007-09-26 2022-05-17 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101500608A (zh) 2006-06-08 2009-08-05 中外制药株式会社 炎性疾病的预防或治疗药
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
MY185647A (en) 2007-12-05 2021-05-27 Chugai Pharmaceutical Co Ltd Therapeutic agent for pruritus
BRPI0821110B8 (pt) 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
KR102469853B1 (ko) 2008-04-11 2022-11-22 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복 결합하는 항원 결합 분자
JP5139517B2 (ja) * 2008-12-05 2013-02-06 中外製薬株式会社 抗nr10抗体、およびその利用
JP2010210772A (ja) * 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
WO2010107110A1 (ja) 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
NZ629829A (en) 2010-04-30 2015-11-27 Alexion Pharma Inc Anti-c5a antibodies and methods for using the antibodies
AU2011337704B2 (en) 2010-11-30 2017-06-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
US9770195B2 (en) * 2012-08-09 2017-09-26 The Regents Of The University Of California Automated scratch detection system and signal processing algorithm for the study of pruritus in animals
KR102641898B1 (ko) 2015-04-14 2024-02-27 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
MA42444A (fr) 2015-07-16 2018-05-23 Lilly Co Eli Traitement du prurit
CN110563844A (zh) * 2019-09-04 2019-12-13 华中农业大学 一种抗犬白介素31受体的多克隆抗体及其应用
MX2023002482A (es) 2020-09-01 2023-03-08 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para prevencion y/o tratamiento de prurito por dialisis que comprende antagonista de interleucina 31 (il-31) como ingrediente activo.
CA3211221A1 (en) * 2021-02-22 2022-08-25 Zoetis Services Llc Horse il-31 induced pruritus model

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US5156840A (en) 1982-03-09 1992-10-20 Cytogen Corporation Amine-containing porphyrin derivatives
JPS58201994A (ja) 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP2898064B2 (ja) 1989-08-03 1999-05-31 忠三 岸本 ヒトgp130蛋白質
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9016440D0 (en) 1990-07-26 1990-09-12 Elopak Systems A laminate
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
DK0605522T3 (da) 1991-09-23 2000-01-17 Medical Res Council Fremgangsmåde til fremstilling af humaniserede antistoffer
DK1024191T3 (da) 1991-12-02 2008-12-08 Medical Res Council Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
ATE381614T1 (de) 1992-07-24 2008-01-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
BR9204244A (pt) 1992-10-26 1994-05-03 Cofap Ferro fundido cinzento
WO1994012215A1 (en) 1992-12-01 1994-06-09 Protein Design Labs, Inc. Humanized antibodies reactive with l-selectin
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
CA2177367A1 (en) 1993-12-03 1995-06-08 Andrew David Griffiths Recombinant binding proteins and peptides
US5783672A (en) 1994-05-26 1998-07-21 Immunex Corporation Receptor for oncostatin M
AU701342B2 (en) 1994-07-13 1999-01-28 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin-8
US5876950A (en) 1995-01-26 1999-03-02 Bristol-Myers Squibb Company Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
FR2729855A1 (fr) * 1995-01-26 1996-08-02 Oreal Utilisation d'un antagoniste de cgrp dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue
ES2304786T3 (es) 1995-04-27 2008-10-16 Amgen Fremont Inc. Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados.
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
AUPN481295A0 (en) 1995-08-16 1995-09-07 Medvet Science Pty. Ltd. Agonists of haemopoietic growth factors
JP3946256B2 (ja) 1995-09-11 2007-07-18 協和醗酵工業株式会社 ヒトインターロイキン5受容体α鎖に対する抗体
AUPN564195A0 (en) 1995-09-26 1995-10-19 Walter And Eliza Hall Institute Of Medical Research, The A novel haemopoietin receptor and genetic sequences encoding same
EP0907730B1 (en) 1995-10-23 2009-10-07 Zenyth Operations Pty Ltd Haemopoietin receptor and genetic sequences encoding same
US6642360B2 (en) * 1997-12-03 2003-11-04 Genentech, Inc. Secreted polypeptides that stimulate release of proteoglycans from cartilage
FR2761994B1 (fr) 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
CA2330547A1 (en) 1998-06-24 1999-12-29 Chugai Research Institute For Molecular Medicine, Inc. Novel hemopoietin receptor proteins
AU776910B2 (en) 1998-12-08 2004-09-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Modifying protein immunogenicity
US20030082734A1 (en) * 1999-06-01 2003-05-01 Dowling Lynette M. Mammalian receptor proteins; related reagents and methods
DK1181366T4 (da) 1999-06-01 2013-09-23 Merck Sharp & Dohme Mammale receptorproteiner, beslægtede reagenser og fremgangsmåder
ATE455852T1 (de) * 1999-06-02 2010-02-15 Chugai Pharmaceutical Co Ltd Neues hämopoietin rezeptorprotein nr10
AU7445900A (en) 1999-09-27 2001-04-30 Chugai Seiyaku Kabushiki Kaisha Novel hemopoietin receptor protein, nr12
ATE396264T1 (de) * 2000-05-10 2008-06-15 Schering Corp Zytokinrezeptoruntereinheit-proteine aus säugetieren, damit zusammenhängende reagenzien und methoden
US20030096339A1 (en) * 2000-06-26 2003-05-22 Sprecher Cindy A. Cytokine receptor zcytor17
PT1325115T (pt) 2000-06-26 2016-09-28 Zymogenetics Inc Recetor de citocina zcytor17
JP2005507632A (ja) 2000-10-06 2005-03-24 イミュネックス・コーポレーション ヘマトポエチン受容体、hpr1およびhpr2
WO2002077230A1 (fr) 2001-03-26 2002-10-03 Chugai Seiyaku Kabushiki Kaisha Variants d'epissage nr10
ATE401390T1 (de) 2002-01-18 2008-08-15 Zymogenetics Inc Zytokin (zcytor17-ligand)
US7494804B2 (en) * 2002-01-18 2009-02-24 Zymogenetics, Inc. Polynucleotide encoding cytokine receptor zcytor17 multimer
EP2110434A1 (en) 2002-02-25 2009-10-21 Genentech, Inc. Type-1 cytokine receptor GLM-R
US7579000B2 (en) * 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
UA85996C2 (ru) * 2002-05-01 2009-03-25 Шеринг Акциенгезельшафт Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору
EP1514928B1 (en) 2002-06-05 2013-07-31 Chugai Seiyaku Kabushiki Kaisha Method for producing antibodies using baculoviruses
US20040223970A1 (en) * 2003-02-28 2004-11-11 Daniel Afar Antibodies against SLC15A2 and uses thereof
WO2004091543A2 (en) 2003-03-04 2004-10-28 Alexion Pharmaceuticals, Inc. Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells
EP1606316A2 (en) 2003-03-24 2005-12-21 ZymoGenetics, Inc. Anti-il-20 antibodies and binding partners and methods of using in inflammation
EP2204190A1 (en) 2003-07-15 2010-07-07 Chugai Seiyaku Kabushiki Kaisha IgM production by transformed cells and methods for quantifying said IgM production
EP1773391A4 (en) 2004-06-25 2009-01-21 Medimmune Inc INCREASING THE PRODUCTION OF RECOMBINANT ANTIBODIES IN MAMMALIAN CELLS BY MUTAGENESIS ON THE SITE
EP1671642A1 (en) 2004-12-15 2006-06-21 Universite D'angers Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof.
ES2557325T5 (es) 2004-12-28 2023-11-15 Innate Pharma Sa Anticuerpos monoclonales contra NKG2A
JP2008528039A (ja) 2005-01-28 2008-07-31 ザイモジェネティクス,インコーポレイティド Il−31の均質調製物
EP1856539B1 (en) 2005-02-14 2015-10-21 ZymoGenetics, Inc. Methods of predicting therapeutic response in atopic dermatitis to il-31 antagonists
JP2008530132A (ja) * 2005-02-14 2008-08-07 ザイモジェネティクス, インコーポレイテッド Il−31raアンタゴニストを用いて皮膚障害を治療する方法
MY148086A (en) 2005-04-29 2013-02-28 Rinat Neuroscience Corp Antibodies directed against amyloid-beta peptide and methods using same
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
MX2007013609A (es) 2005-05-06 2008-01-24 Zymogenetics Inc Anticuerpos monoclonales de il-31 y meodos de uso.
EP2594585A1 (en) 2006-01-10 2013-05-22 Zymogenetics, Inc. Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists
CN101500608A (zh) * 2006-06-08 2009-08-05 中外制药株式会社 炎性疾病的预防或治疗药
US7858756B2 (en) * 2006-06-15 2010-12-28 The Board Of Trustees Of The University Of Arkansas Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds
WO2008100995A1 (en) * 2007-02-14 2008-08-21 Vaccinex, Inc. Humanized anti-cd100 antibodies
CA2678749C (en) 2007-02-23 2018-03-13 Schering Corporation Engineered anti-il-23p19 antibodies
GB0708002D0 (en) 2007-04-25 2007-06-06 Univ Sheffield Antibodies
CL2008002886A1 (es) 2007-09-26 2009-12-04 Chugai Pharmaceutical Co Ltd Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende.
PE20140132A1 (es) 2007-09-26 2014-02-14 Chugai Pharmaceutical Co Ltd Anticuerpo anti-receptor de il-6
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
BRPI0821110B8 (pt) 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
MY185647A (en) 2007-12-05 2021-05-27 Chugai Pharmaceutical Co Ltd Therapeutic agent for pruritus

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US11332533B2 (en) 2007-09-26 2022-05-17 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region
US10253091B2 (en) 2009-03-19 2019-04-09 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US10544227B2 (en) 2015-04-14 2020-01-28 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
US11773173B2 (en) 2015-04-14 2023-10-03 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
US11260125B2 (en) 2019-11-20 2022-03-01 Chugai Seiyaku Kabushiki Kaisha Anti-IL31RA antibody-containing formulations

Also Published As

Publication number Publication date
AU2008332276A1 (en) 2009-06-11
RU2010127291A (ru) 2012-01-10
CN101939025B (zh) 2015-03-25
JPWO2009072598A1 (ja) 2011-04-28
RU2014150548A (ru) 2015-07-20
RU2596397C2 (ru) 2016-09-10
AU2008332276B2 (en) 2014-02-27
US20100310556A1 (en) 2010-12-09
TWI441649B (zh) 2014-06-21
KR20100100935A (ko) 2010-09-15
BRPI0821145B1 (pt) 2019-10-15
CN101939025A (zh) 2011-01-05
BRPI0821145B8 (pt) 2021-05-25
CN104162155A (zh) 2014-11-26
HK1200697A1 (en) 2015-08-14
EP2241332A1 (en) 2010-10-20
RU2541780C2 (ru) 2015-02-20
WO2009072598A1 (ja) 2009-06-11
TW200932265A (en) 2009-08-01
MY162546A (en) 2017-06-15
KR101595134B1 (ko) 2016-02-17
CA2708065A1 (en) 2009-06-11
HK1151226A1 (en) 2012-01-27
JP5475460B2 (ja) 2014-04-16
US8431127B2 (en) 2013-04-30
CA2708065C (en) 2015-02-24
MX2010006097A (es) 2010-08-04
EP2241332A4 (en) 2011-01-26
MY185647A (en) 2021-05-27

Similar Documents

Publication Publication Date Title
BRPI0821145A2 (pt) Agente terapêutico para prurido
BRPI0812209A2 (pt) Partícula de liberação contendo agente de benefício
DK2144905T3 (da) Terapeutiske midler
BRPI0916931A2 (pt) agentes terapêuticos
BRPI0719594A2 (pt) Partícula de liberação contendo agente de benefício
BRPI0816252A2 (pt) Implemento para cuidado pessoal
BRPI0813725A2 (pt) Métodos e composições para tratamento de doenças
DK2035369T3 (da) Terapeutiske
BRPI0807137A2 (pt) Agentes antiparasitários
BRPI0813670A2 (pt) Compostos para tratamento
DK2185142T3 (da) Antiseptiske midler
BR112012005247A2 (pt) agente antifitoviral
BRPI0815970A2 (pt) composição para cuidado pessoal
BRPI0810091A2 (pt) Agentes fugicidas tópicos para tratar distúrbios ungueais
BRPI0820410A2 (pt) Lactans substituídos terapêuticos
DK2131818T3 (da) Ny doseringsform
BRPI0818598A2 (pt) agentes terapêuticos - 802
DK2246477T3 (da) Spunspæl med dobbelt t-form
SMT201600041B (it) Agenti terapeutici 713
BRPI0814438A2 (pt) Agente de gelificação para baterias
BRPI0812000A2 (pt) Métodos e composições para administração de oxibutinina
BRPI0810762A2 (pt) Composição para tratamento da água
BRPI0811222A2 (pt) Agente terapêutico para infarto cerebral.
BRPI0813832A2 (pt) Métodos para tratamento da ansiedade
DK2041128T3 (da) Substituerede gamma-lactamer som terapeutiske agenser

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/12/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF