BRPI0820950A2 - Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto. - Google Patents

Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto.

Info

Publication number
BRPI0820950A2
BRPI0820950A2 BRPI0820950-2A BRPI0820950A BRPI0820950A2 BR PI0820950 A2 BRPI0820950 A2 BR PI0820950A2 BR PI0820950 A BRPI0820950 A BR PI0820950A BR PI0820950 A2 BRPI0820950 A2 BR PI0820950A2
Authority
BR
Brazil
Prior art keywords
compound
diseases
treating
preparing
methods
Prior art date
Application number
BRPI0820950-2A
Other languages
English (en)
Inventor
Joseph W Boyd
Giles A Brown
Michael Higginbottom
Iain Simpson
Viet-Anh Anne-Nee-Nguyen Horgan
Jacqueline Ouzman
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0820950A2 publication Critical patent/BRPI0820950A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
BRPI0820950-2A 2007-12-05 2008-12-05 Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto. BRPI0820950A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0702697 2007-12-05
US2293308P 2008-01-23 2008-01-23
PCT/EP2008/066899 WO2009071668A2 (en) 2007-12-05 2008-12-05 Piperazine derivatives and their use as leptin receptor modulators

Publications (1)

Publication Number Publication Date
BRPI0820950A2 true BRPI0820950A2 (pt) 2015-07-07

Family

ID=40673212

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820950-2A BRPI0820950A2 (pt) 2007-12-05 2008-12-05 Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto.

Country Status (12)

Country Link
US (1) US8093248B2 (pt)
EP (1) EP2234992B1 (pt)
JP (1) JP2011506295A (pt)
KR (1) KR20100096222A (pt)
CN (1) CN102015668A (pt)
AT (1) ATE546441T1 (pt)
AU (1) AU2008333183A1 (pt)
BR (1) BRPI0820950A2 (pt)
CA (1) CA2707248A1 (pt)
MX (1) MX2010006215A (pt)
RU (1) RU2010126842A (pt)
WO (1) WO2009071668A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102026975A (zh) * 2007-12-05 2011-04-20 阿斯利康(瑞典)有限公司 作为抗肥胖药的哌嗪衍生物
BRPI0820950A2 (pt) 2007-12-05 2015-07-07 Astrazeneca Ab Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto.
JP2011506298A (ja) * 2007-12-05 2011-03-03 アストラゼネカ アクチボラグ 新規化合物ｉｖ
CN102166214B (zh) * 2011-03-02 2012-12-12 华中科技大学同济医学院附属同济医院 氨基噻唑类MyD88特异性抑制剂在医学上的用途
US9034874B2 (en) * 2012-07-20 2015-05-19 Novartis Ag Carbamate/urea derivatives
CN105622528B (zh) * 2016-02-01 2017-12-15 新乡医学院第一附属医院 一种治疗肺动脉高压的化合物及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
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DE3420193A1 (de) 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
TR199802534T2 (xx) 1996-06-06 1999-03-22 Smithkline Beecham P.L.C. Leptin (OB Protein) fragmanlar�
TW434220B (en) 1998-02-02 2001-05-16 Shiseido Co Ltd 1,2-di-substituted piperidine derivative, a hair growth agent, and an agent for external use to the skin
JP2001131149A (ja) 1999-11-08 2001-05-15 Sumitomo Pharmaceut Co Ltd 選択的セロトニン再取り込み阻害剤
JP2001261657A (ja) 2000-03-17 2001-09-26 Yamanouchi Pharmaceut Co Ltd シアノフェニル誘導体
WO2002026723A1 (en) 2000-09-29 2002-04-04 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
AU2002344951A1 (en) 2001-07-02 2003-01-21 Boehringer Ingelheim International Gmbh Substituted piperazine and diazepanes as histamine h3 receptor agonists
ES2197003B1 (es) 2002-04-08 2005-03-16 J. URIACH & CIA S.A. Nuevos compuestos antagonistas de integrinas alfa.
JP2006509815A (ja) 2002-12-13 2006-03-23 ファイザー・プロダクツ・インク 新規なリン含有誘導体
KR20060065584A (ko) * 2003-06-20 2006-06-14 아레나 파마슈티칼스, 인크. Ｎ-페닐-피페라진 유도체 및 5ｈｔ2ｃ 수용체 관련 질환의예방 또는 치료 방법
MX2007006695A (es) 2004-12-03 2007-08-14 Schering Corp Piperazinas sustituidas como antagonistas de cb1.
DE102005000666B3 (de) 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1909791A1 (en) 2005-06-30 2008-04-16 Prosidion Limited G-protein coupled receptor agonists
US20090325975A1 (en) 2005-07-15 2009-12-31 Helmut H Buschmann Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
EP1787679A1 (en) 2005-07-29 2007-05-23 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
US7851474B2 (en) 2005-08-02 2010-12-14 Neurogen Corporation Dipiperazinyl ketones and related analogues
US7790726B2 (en) 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
WO2007098939A1 (en) 2006-02-28 2007-09-07 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
US20080058339A1 (en) 2006-08-30 2008-03-06 Biovitrum New compounds
WO2008121592A2 (en) 2007-03-30 2008-10-09 Takeda Pharmaceutical Company Limited Acetyl coenzyme a carboxylase inhibitors
TW200902007A (en) 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
JP2011506298A (ja) 2007-12-05 2011-03-03 アストラゼネカ アクチボラグ 新規化合物ｉｖ
BRPI0820950A2 (pt) 2007-12-05 2015-07-07 Astrazeneca Ab Composto, formulação farmacêutica, uso de um composto, métodos para o tratamento ou prevenção de condições ou doenças e para inibição da angiogênese, e, processo para a preparação de um composto.
CN102026975A (zh) 2007-12-05 2011-04-20 阿斯利康(瑞典)有限公司 作为抗肥胖药的哌嗪衍生物
US20090176798A1 (en) 2007-12-05 2009-07-09 Biovitrum Ab New compounds III
US20110275670A1 (en) 2008-06-04 2011-11-10 Emma Chapman New Compounds VII
WO2009147216A1 (en) 2008-06-04 2009-12-10 Biovitrum Ab (Publ) New pyridine derivatives as leptin receptor modulator mimetics
CN102245183A (zh) 2008-06-04 2011-11-16 阿斯利康(瑞典)有限公司 新化合物v
US20110275638A1 (en) 2008-06-04 2011-11-10 Emma Chapman Piperazine derivatives and their use as leptin receptor modulators

Also Published As

Publication number Publication date
EP2234992A2 (en) 2010-10-06
WO2009071668A2 (en) 2009-06-11
WO2009071668A3 (en) 2009-08-20
KR20100096222A (ko) 2010-09-01
US8093248B2 (en) 2012-01-10
RU2010126842A (ru) 2012-01-10
EP2234992B1 (en) 2012-02-22
JP2011506295A (ja) 2011-03-03
AU2008333183A1 (en) 2009-06-11
MX2010006215A (es) 2010-08-17
CN102015668A (zh) 2011-04-13
ATE546441T1 (de) 2012-03-15
CA2707248A1 (en) 2009-06-11
US20090281087A1 (en) 2009-11-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.