ATE546441T1 - Piperazinderivate und ihre verwendung als modulatoren des leptinrezeptors - Google Patents
Piperazinderivate und ihre verwendung als modulatoren des leptinrezeptorsInfo
- Publication number
- ATE546441T1 ATE546441T1 AT08857800T AT08857800T ATE546441T1 AT E546441 T1 ATE546441 T1 AT E546441T1 AT 08857800 T AT08857800 T AT 08857800T AT 08857800 T AT08857800 T AT 08857800T AT E546441 T1 ATE546441 T1 AT E546441T1
- Authority
- AT
- Austria
- Prior art keywords
- leptin receptor
- modulators
- piperazine derivatives
- compounds
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0702697 | 2007-12-05 | ||
US2293308P | 2008-01-23 | 2008-01-23 | |
PCT/EP2008/066899 WO2009071668A2 (en) | 2007-12-05 | 2008-12-05 | Piperazine derivatives and their use as leptin receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE546441T1 true ATE546441T1 (de) | 2012-03-15 |
Family
ID=40673212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08857800T ATE546441T1 (de) | 2007-12-05 | 2008-12-05 | Piperazinderivate und ihre verwendung als modulatoren des leptinrezeptors |
Country Status (12)
Country | Link |
---|---|
US (1) | US8093248B2 (de) |
EP (1) | EP2234992B1 (de) |
JP (1) | JP2011506295A (de) |
KR (1) | KR20100096222A (de) |
CN (1) | CN102015668A (de) |
AT (1) | ATE546441T1 (de) |
AU (1) | AU2008333183A1 (de) |
BR (1) | BRPI0820950A2 (de) |
CA (1) | CA2707248A1 (de) |
MX (1) | MX2010006215A (de) |
RU (1) | RU2010126842A (de) |
WO (1) | WO2009071668A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100097701A (ko) * | 2007-12-05 | 2010-09-03 | 아스트라제네카 아베 | 비만 치료제로서의 모르폴린 유도체 |
MX2010006215A (es) | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de piperazina y su uso como moduladores del receptor de leptina. |
BRPI0819989A2 (pt) | 2007-12-05 | 2015-05-12 | Biovitrum Ab Publ | Composto, formulação farmacêutica, uso de um composto, processo para a preparação de um composto, e, métodos para tratamento ou prevenção de condições ou doênças e para inibição da angiogênese |
CN102166214B (zh) * | 2011-03-02 | 2012-12-12 | 华中科技大学同济医学院附属同济医院 | 氨基噻唑类MyD88特异性抑制剂在医学上的用途 |
US9034874B2 (en) * | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
CN105622528B (zh) * | 2016-02-01 | 2017-12-15 | 新乡医学院第一附属医院 | 一种治疗肺动脉高压的化合物及其应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3420193A1 (de) | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
CA2257240A1 (en) | 1996-06-06 | 1997-12-11 | Smithkline Beecham P.L.C. | Fragments of leptin (ob protein) |
US6057337A (en) | 1998-02-02 | 2000-05-02 | Shiseido Co., Ltd. | 1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same |
JP2001131149A (ja) | 1999-11-08 | 2001-05-15 | Sumitomo Pharmaceut Co Ltd | 選択的セロトニン再取り込み阻害剤 |
JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
EP1586567A1 (de) | 2000-09-29 | 2005-10-19 | Glaxo Group Limited | Verbindungen verwendbar für die Behandlung von Entzündungskrankheiten |
GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
JP2005502623A (ja) | 2001-07-02 | 2005-01-27 | ノボ ノルディスク アクティーゼルスカブ | 置換ピペラジンおよびジアゼパン |
ES2197003B1 (es) * | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
MXPA05006229A (es) | 2002-12-13 | 2005-08-19 | Pfizer Prod Inc | Derivados de piperazina que contienen fosforo como antagonistas de ccr1. |
EA200600071A1 (ru) | 2003-06-20 | 2006-08-25 | Арена Фармасьютикалз, Инк. | Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором |
ES2435790T3 (es) | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
DE102005000666B3 (de) | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US20090203676A1 (en) | 2005-06-30 | 2009-08-13 | Oscar Barba | G-protein Coupled Receptor Agonists |
WO2007025613A2 (en) | 2005-07-15 | 2007-03-08 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
EP1787679A1 (de) | 2005-07-29 | 2007-05-23 | Laboratorios Del Dr. Esteve, S.A. | Verwendung von Verbindungen, die an den Sigma-Rezeptor binden zur Behandlung von Diabetes-assoziiertem Schmerz |
WO2007016496A2 (en) | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
US20090181976A1 (en) | 2006-02-28 | 2009-07-16 | Buschmann Helmut H | Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome |
CA2660699A1 (en) | 2006-08-30 | 2008-03-06 | Biovitrum Ab (Publ) | Pyridine compounds for treating gpr119 related disorders |
WO2008121592A2 (en) | 2007-03-30 | 2008-10-09 | Takeda Pharmaceutical Company Limited | Acetyl coenzyme a carboxylase inhibitors |
TW200902007A (en) | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
MX2010006215A (es) | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de piperazina y su uso como moduladores del receptor de leptina. |
BRPI0819989A2 (pt) * | 2007-12-05 | 2015-05-12 | Biovitrum Ab Publ | Composto, formulação farmacêutica, uso de um composto, processo para a preparação de um composto, e, métodos para tratamento ou prevenção de condições ou doênças e para inibição da angiogênese |
AU2008333110A1 (en) * | 2007-12-05 | 2009-06-11 | Astrazeneca Ab (Publ) | New compounds III |
KR20100097701A (ko) * | 2007-12-05 | 2010-09-03 | 아스트라제네카 아베 | 비만 치료제로서의 모르폴린 유도체 |
RU2010148901A (ru) | 2008-06-04 | 2012-07-20 | Астразенека Аб (Se) | Новые производные пиридина в качестве миметиков модуляторов лептинового рецептора |
KR20110015446A (ko) | 2008-06-04 | 2011-02-15 | 아스트라제네카 아베 | 렙틴 수용체 조절제 유사체로서의 신규한 피리딘 유도체 |
MX2010013354A (es) | 2008-06-04 | 2010-12-21 | Astrazeneca Ab | Moduladores del receptor de leptina de molecula pequeña. |
AU2009254555A1 (en) | 2008-06-04 | 2009-12-10 | Astrazeneca Ab (Publ) | New compounds VII |
-
2008
- 2008-12-05 MX MX2010006215A patent/MX2010006215A/es unknown
- 2008-12-05 EP EP08857800A patent/EP2234992B1/de not_active Not-in-force
- 2008-12-05 RU RU2010126842/04A patent/RU2010126842A/ru not_active Application Discontinuation
- 2008-12-05 KR KR1020107014729A patent/KR20100096222A/ko not_active Application Discontinuation
- 2008-12-05 AU AU2008333183A patent/AU2008333183A1/en not_active Abandoned
- 2008-12-05 CA CA2707248A patent/CA2707248A1/en not_active Abandoned
- 2008-12-05 BR BRPI0820950-2A patent/BRPI0820950A2/pt not_active IP Right Cessation
- 2008-12-05 WO PCT/EP2008/066899 patent/WO2009071668A2/en active Application Filing
- 2008-12-05 CN CN200880126626XA patent/CN102015668A/zh active Pending
- 2008-12-05 US US12/315,831 patent/US8093248B2/en not_active Expired - Fee Related
- 2008-12-05 AT AT08857800T patent/ATE546441T1/de active
- 2008-12-05 JP JP2010536474A patent/JP2011506295A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2234992B1 (de) | 2012-02-22 |
CA2707248A1 (en) | 2009-06-11 |
CN102015668A (zh) | 2011-04-13 |
KR20100096222A (ko) | 2010-09-01 |
JP2011506295A (ja) | 2011-03-03 |
US20090281087A1 (en) | 2009-11-12 |
RU2010126842A (ru) | 2012-01-10 |
BRPI0820950A2 (pt) | 2015-07-07 |
US8093248B2 (en) | 2012-01-10 |
EP2234992A2 (de) | 2010-10-06 |
WO2009071668A2 (en) | 2009-06-11 |
WO2009071668A3 (en) | 2009-08-20 |
AU2008333183A1 (en) | 2009-06-11 |
MX2010006215A (es) | 2010-08-17 |
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