BRPI0819331A2 - Métodos e composições para o tratamento do olho seco - Google Patents

Métodos e composições para o tratamento do olho seco

Info

Publication number
BRPI0819331A2
BRPI0819331A2 BRPI0819331A BRPI0819331A2 BR PI0819331 A2 BRPI0819331 A2 BR PI0819331A2 BR PI0819331 A BRPI0819331 A BR PI0819331A BR PI0819331 A2 BRPI0819331 A2 BR PI0819331A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
dry eye
treating dry
treating
Prior art date
Application number
Other languages
English (en)
Inventor
Bor-Shyue Hong
David L Meadows
Original Assignee
Alcon Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Res Ltd filed Critical Alcon Res Ltd
Publication of BRPI0819331A2 publication Critical patent/BRPI0819331A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018Hydrolysed proteins; Derivatives thereof from animals from milk
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
BRPI0819331 2007-11-16 2008-11-14 Métodos e composições para o tratamento do olho seco BRPI0819331A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98862307P 2007-11-16 2007-11-16
PCT/US2008/083551 WO2009064983A1 (en) 2007-11-16 2008-11-14 Methods and compositions for treating dry eye

Publications (1)

Publication Number Publication Date
BRPI0819331A2 true BRPI0819331A2 (pt) 2015-05-12

Family

ID=40347942

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819331 BRPI0819331A2 (pt) 2007-11-16 2008-11-14 Métodos e composições para o tratamento do olho seco

Country Status (11)

Country Link
US (1) US20090131303A1 (pt)
EP (1) EP2207598A1 (pt)
JP (1) JP2011503202A (pt)
KR (1) KR20100087188A (pt)
CN (1) CN101861187A (pt)
AU (1) AU2008322545A1 (pt)
BR (1) BRPI0819331A2 (pt)
CA (1) CA2703814A1 (pt)
RU (1) RU2470662C2 (pt)
TW (1) TW200930383A (pt)
WO (1) WO2009064983A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1400996B1 (it) * 2010-06-14 2013-07-05 Silvestrini Metodo per il trattamento dell'occhio secco con gelatina somministrata per via orale
US9453833B2 (en) 2011-01-07 2016-09-27 Digital Diagnostics Pty. Ltd. System and method for detecting and monitoring proteolysis of protein matrices
JP6131192B2 (ja) * 2011-01-07 2017-05-17 ザ ユニバーシティ オブ クィーンズランド タンパク質分解の検出
CN103533926A (zh) * 2011-01-24 2014-01-22 安特里奥公司 空纳米颗粒组合物及其用于治疗皮肤病学病症的用途
MX2014006056A (es) * 2011-12-06 2014-08-08 Alcon Res Ltd Composicion de gel de celulosa con una mejor estabilidad de la viscosidad.
ES2762153T3 (es) 2013-02-01 2020-05-22 Ocuphire Pharma Inc Soluciones oftálmicas acuosas de fentolamina y usos médicos de las mismas
CA2899342C (en) 2013-02-01 2021-09-21 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
KR101692578B1 (ko) * 2013-04-18 2017-01-03 삼진제약주식회사 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물
KR101721059B1 (ko) * 2014-12-26 2017-03-30 주식회사 아이바이오코리아 안구 표면 질환 예방 또는 치료용 약학조성물
US10071181B1 (en) * 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
KR101690539B1 (ko) * 2015-07-30 2016-12-29 주식회사 아이바이오코리아 건성안 예방 또는 치료용 약학조성물
US10632202B2 (en) 2016-03-04 2020-04-28 Johnson & Johnson Consumer Inc. Preservative containing compositions
ES2819030T3 (es) 2016-04-08 2021-04-14 Eyebio Korea Péptido basado en colágeno tipo II alfa-1 útil para el tratamiento de una enfermedad de la superficie ocular
KR101798183B1 (ko) 2016-04-08 2017-11-15 주식회사 아이바이오코리아 건성안 예방 또는 치료용 약학조성물
RU2620568C1 (ru) * 2016-04-12 2017-05-26 Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПбГПМУ Минздрава России) Препарат для лечения синдрома "сухого глаза"
RU2646804C1 (ru) * 2016-12-28 2018-03-07 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Офтальмологическое средство для регенерации роговицы глаза
KR102287226B1 (ko) * 2017-05-17 2021-08-11 주식회사 유유제약 신규한 펩타이드 및 이를 유효성분으로 포함하는 안구질환 치료용 약학 조성물
RU2677190C1 (ru) * 2017-11-28 2019-01-15 федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России) Способ лечения патологии суммарной слезопродукции у пациентов с ревматоидным артритом
BR112021007725A2 (pt) 2018-10-26 2021-07-27 Ocuphire Pharma, Inc. métodos e composições para tratamento de presbiopia, midríase e outros distúrbios oculares
US11613558B2 (en) 2018-11-14 2023-03-28 Yuyu Pharma, Inc. Peptides and pharmaceutical compositions for treating eye diseases
TWI757773B (zh) 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
US11931454B2 (en) 2019-09-18 2024-03-19 Alcon Inc. Wet-packed soft hydrogel ocular inserts
US20210196652A1 (en) * 2019-12-27 2021-07-01 Meshaberase, LLC Use of cysteamine and derivatives thereof to treat dysfunctional tear syndrome (dts)
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
CN113713086A (zh) * 2021-08-20 2021-11-30 山西锦波生物医药股份有限公司 一种含有重组iii型人源化胶原蛋白的组合物及其制备方法和用途
US20230310615A1 (en) * 2022-03-31 2023-10-05 Alcon Inc. Ophthalmic compositions

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039662A (en) * 1975-12-04 1977-08-02 Alcon Laboratories, Inc. Ophthalmic solution
US4447562A (en) * 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US4365050A (en) * 1981-07-15 1982-12-21 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US5112805A (en) * 1985-11-22 1992-05-12 Labsystems, Oy Pharmaceutical preparation for promoting epithelial healing and prevention of epithelial destruction
FI854634A0 (fi) * 1985-11-22 1985-11-22 Labsystems Oy Foerfarande foer bestaemning av proteolytisk aktivitet.
US5188826A (en) * 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US4923700A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
DE3827561C1 (pt) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
RU2094031C1 (ru) * 1992-04-09 1997-10-27 Малое государственное предприятие "Научно-экспериментальное производство" Способ профилактики новообразованных сосудов роговицы после сквозной и послойной кератопластики
JPH06256209A (ja) * 1993-03-03 1994-09-13 Fuji Yakuhin Kogyo Kk 眼球及びその周辺部組織の潰瘍に対する予防・治療剤
US5652209A (en) * 1994-04-29 1997-07-29 University Of Miami Use of secretory products of human lacrimal gland acinar epithelia for tear replacement therapy
US5698533A (en) * 1994-07-26 1997-12-16 Kang; Meng-Che Ophthalmic pharmaceutical composition
US5518732A (en) * 1995-02-14 1996-05-21 Chiron Vision, Inc. Bio-erodible ophthalmic shield
US5888493A (en) * 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
GB2320431B (en) * 1996-12-20 2000-08-30 Johnson & Johnson Medical Compositions for the treatment of chronic wounds
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
ES2206965T3 (es) * 1997-07-29 2004-05-16 Alcon Laboratories, Inc. Composiciones oftalmicas que contienen polimeros de galactomanana y borato.
CA2331257C (en) * 1998-05-08 2012-01-03 University Of Miami Use of tetracyclines for treating meibomian gland disease
US6217896B1 (en) * 1999-04-01 2001-04-17 Uab Research Foundation Conjunctival inserts for topical delivery of medication or lubrication
AU783019B2 (en) * 1999-07-13 2005-09-15 University Of Southern California Novel method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and beta1 integrins
EP1231936A2 (en) * 1999-10-27 2002-08-21 K-Quay Enterprises, LLC Methods and compositions for treatment of keratoconus using protease inhibitors
AU2002232437A1 (en) * 2000-12-20 2002-07-01 Alcon Universal Ltd. Ophthalmic lubricating solution adapted for use in lasik surgery
US20030215471A1 (en) * 2001-01-31 2003-11-20 Wilmott James M. Surfactant free topical compositions and method for rapid preparation thereof
US20030223957A1 (en) * 2002-04-10 2003-12-04 Schwartz Daniel M. Biodegradable PEG based polymer formulations in ocular applications
US20050256081A1 (en) * 2004-02-26 2005-11-17 Peyman Gholam A Tetracycline derivatives for the treatment of ocular pathologies
US20060074108A1 (en) * 2004-10-04 2006-04-06 Bioderm Research Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition
CA2615990A1 (en) * 2005-07-18 2007-01-25 Minu, L.L.C. Enhanced ocular neuroprotection/neurostimulation
CN100381169C (zh) * 2005-09-08 2008-04-16 佟刚 复合胶原蛋白滴眼液
WO2008011836A2 (es) * 2006-07-25 2008-01-31 Osmotica Corp. Soluciones oftálmicas

Also Published As

Publication number Publication date
RU2470662C2 (ru) 2012-12-27
WO2009064983A1 (en) 2009-05-22
EP2207598A1 (en) 2010-07-21
KR20100087188A (ko) 2010-08-03
AU2008322545A1 (en) 2009-05-22
CA2703814A1 (en) 2009-05-22
US20090131303A1 (en) 2009-05-21
TW200930383A (en) 2009-07-16
JP2011503202A (ja) 2011-01-27
CN101861187A (zh) 2010-10-13
RU2010123929A (ru) 2011-12-27

Similar Documents

Publication Publication Date Title
BRPI0819331A2 (pt) Métodos e composições para o tratamento do olho seco
BRPI0813553A2 (pt) composições farmacêuticas e métodos para tratamento de distúrbios do olho seco
BRPI0719918A2 (pt) Tratamento para olho seco usando-se testosterona e progestagênio
BRPI0908854A2 (pt) composições e métodos para o tratamento de tumor de origem hematopoética
BRPI0920326A2 (pt) composição e método para tratamento da síndrome do olho ressecado
BRPI0915205A2 (pt) compostos e composições úteis para o tratamento de malária
BRPI0916323A2 (pt) composições antimicrobianas de liberação controlada e métodos para o tratamento de distúrbios do ouvido
BRPI0909627A2 (pt) métodos, composições e kits para tratar dores e pruridos
BRPI0911757A2 (pt) composiÇÕes e mÉtodos para tratar distérbios digestivos.
BRPI0813725A2 (pt) Métodos e composições para tratamento de doenças
BRPI0922122A2 (pt) composições e métodos para tratamento de doença celíaca.
BRPI1012182A2 (pt) composições e métodos para tratar isquemia e lesão de isquemia-reperfusão
BRPI0821731A8 (pt) composições cosméticas para conceder flimes superhidrofóbicos
BRPI0807918A2 (pt) composições e método para preservação de tecido
BRPI0923760A2 (pt) artigos nanoestruturados e métodos para fabricação de artigos nanoestruturados
BRPI0820084A2 (pt) Composição e método para aplicação de rímel seco
BRPI0822349A2 (pt) composições e métodos para tratar doenças lisossômicas
BRPI1011721A2 (pt) formulações em pó seco e métodos para tratar doenças pulmonares.
BRPI0921321A2 (pt) métodos para o tratamento de indwcções e tumores
BRPI0819911A2 (pt) composições compreendendo agonistas nicotínicos e métodos para usar as mesmas
BRPI0820980A2 (pt) Composições e métodos para detecção de tiabs
BRPI1012213A2 (pt) "solventes e composições para tratamento de formações contendo hidrocarboneto"
BRPI0919238A2 (pt) métodos e composições para o tratamento de câncer
BR112014014234A2 (pt) composição não colorante para tratar as fibras queratínicas e método para tratar as fibras queratínicas
BRPI0810525A2 (pt) Composições e métodos para a profilaxia e tratamento de dependência química

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.