BRPI0810063A2 - Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina - Google Patents

Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina

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Publication number
BRPI0810063A2
BRPI0810063A2 BRPI0810063-2A2A BRPI0810063A BRPI0810063A2 BR PI0810063 A2 BRPI0810063 A2 BR PI0810063A2 BR PI0810063 A BRPI0810063 A BR PI0810063A BR PI0810063 A2 BRPI0810063 A2 BR PI0810063A2
Authority
BR
Brazil
Prior art keywords
individual
cell
inhibit
eye
retinal
Prior art date
Application number
BRPI0810063-2A2A
Other languages
English (en)
Portuguese (pt)
Inventor
Ian Leslie Scott
Vladimir Aleksandrovich Kuksa
Anna Gall
Mark W Orme
Jennifer Gage
Thomas L Little
Qin Jiang
Lana Michele Rossiter
Kevin F Mcgee
Ryo Kubota
Original Assignee
Acucela Inc
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Filing date
Publication date
Application filed by Acucela Inc filed Critical Acucela Inc
Publication of BRPI0810063A2 publication Critical patent/BRPI0810063A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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BRPI0810063-2A2A 2007-04-20 2008-04-21 Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina BRPI0810063A2 (pt)

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US8420863B2 (en) 2013-04-16
ZA200907313B (en) 2011-03-30
US9421210B2 (en) 2016-08-23
JP5371953B2 (ja) 2013-12-18
RU2494089C2 (ru) 2013-09-27
AU2008242626A1 (en) 2008-10-30
US20090170841A1 (en) 2009-07-02
IL201285A0 (en) 2010-05-31
JP2010524975A (ja) 2010-07-22
KR101368248B1 (ko) 2014-03-14
ECSP099695A (es) 2010-01-29
US9314467B2 (en) 2016-04-19
CA2681850C (en) 2013-07-23
WO2008131368A2 (en) 2008-10-30
US20150166495A1 (en) 2015-06-18
WO2008131368A3 (en) 2008-12-24
IL201285A (en) 2014-11-30
CO6251201A2 (es) 2011-02-21
AU2008242626B2 (en) 2012-04-12
MY161818A (en) 2017-05-15
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US20130253064A1 (en) 2013-09-26

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