BRPI0808776A2 - Fenóxi amino tiazolonas substituídas como moduladores de receptor-alfa relacionado a estrogênio - Google Patents

Info

Publication number

BRPI0808776A2

BRPI0808776A2 BRPI0808776-8A BRPI0808776A BRPI0808776A2 BR PI0808776 A2 BRPI0808776 A2 BR PI0808776A2 BR PI0808776 A BRPI0808776 A BR PI0808776A BR PI0808776 A2 BRPI0808776 A2 BR PI0808776A2

Authority

BR

Brazil

Prior art keywords

methyl

formula

oxo

thiazol

phenoxy

Prior art date

2007-03-07

Links

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• -1 PHENOXY AMINO Chemical class 0.000 title description 285
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 65
• 230000008569 process Effects 0.000 claims description 46
• 125000000217 alkyl group Chemical group 0.000 claims description 40
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• 208000035475 disorder Diseases 0.000 claims description 30
• 125000005843 halogen group Chemical group 0.000 claims description 28
• 125000000623 heterocyclic group Chemical group 0.000 claims description 28
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
• 239000008194 pharmaceutical composition Substances 0.000 claims description 26
• 229910052731 fluorine Inorganic materials 0.000 claims description 25
• 150000003839 salts Chemical class 0.000 claims description 25
• 239000003795 chemical substances by application Substances 0.000 claims description 24
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
• 210000000988 bone and bone Anatomy 0.000 claims description 19
• 239000003112 inhibitor Substances 0.000 claims description 19
• 125000003545 alkoxy group Chemical group 0.000 claims description 18
• 239000000651 prodrug Substances 0.000 claims description 18
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• 230000000694 effects Effects 0.000 claims description 17
• 230000001404 mediated effect Effects 0.000 claims description 16
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• 125000003118 aryl group Chemical group 0.000 claims description 15
• 125000001072 heteroaryl group Chemical group 0.000 claims description 15
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• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 14
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