BRPI0808503B8 - composto, uso de um composto, e, composição farmacêutica - Google Patents
composto, uso de um composto, e, composição farmacêuticaInfo
- Publication number
- BRPI0808503B8 BRPI0808503B8 BRPI0808503A BRPI0808503A BRPI0808503B8 BR PI0808503 B8 BRPI0808503 B8 BR PI0808503B8 BR PI0808503 A BRPI0808503 A BR PI0808503A BR PI0808503 A BRPI0808503 A BR PI0808503A BR PI0808503 B8 BRPI0808503 B8 BR PI0808503B8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- relates
- alzheimer
- disease
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 239000002243 precursor Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89314907P | 2007-03-06 | 2007-03-06 | |
| US60/893149 | 2007-03-06 | ||
| US60/893,149 | 2007-03-06 | ||
| PCT/SE2008/050243 WO2008108730A1 (en) | 2007-03-06 | 2008-03-05 | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes 709 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0808503A2 BRPI0808503A2 (pt) | 2014-08-19 |
| BRPI0808503B1 BRPI0808503B1 (pt) | 2020-09-29 |
| BRPI0808503B8 true BRPI0808503B8 (pt) | 2021-05-25 |
Family
ID=39738510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0808503A BRPI0808503B8 (pt) | 2007-03-06 | 2008-03-05 | composto, uso de um composto, e, composição farmacêutica |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7772256B2 (enExample) |
| EP (1) | EP2132201B1 (enExample) |
| JP (1) | JP5631009B2 (enExample) |
| KR (1) | KR101530392B1 (enExample) |
| CN (2) | CN102617556A (enExample) |
| AR (1) | AR065599A1 (enExample) |
| AU (1) | AU2008221668B2 (enExample) |
| BR (1) | BRPI0808503B8 (enExample) |
| CA (1) | CA2680157C (enExample) |
| CL (1) | CL2008000645A1 (enExample) |
| CO (1) | CO6220965A2 (enExample) |
| EC (1) | ECSP099641A (enExample) |
| ES (1) | ES2615381T3 (enExample) |
| IL (1) | IL200524A0 (enExample) |
| MX (1) | MX2009009469A (enExample) |
| MY (1) | MY147347A (enExample) |
| NZ (1) | NZ579157A (enExample) |
| PE (1) | PE20090164A1 (enExample) |
| SA (1) | SA08290097B1 (enExample) |
| TW (1) | TW200901998A (enExample) |
| UA (1) | UA98481C2 (enExample) |
| UY (1) | UY30951A1 (enExample) |
| WO (1) | WO2008108730A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
| JP2011524864A (ja) | 2008-05-30 | 2011-09-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な置換されたアザベンゾオキサゾール |
| BRPI0917540A2 (pt) | 2008-08-05 | 2015-11-17 | Daiichi Sankyo Co Ltd | composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável |
| US8193363B2 (en) * | 2008-08-29 | 2012-06-05 | Astrazeneca Ab | Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| EP2388255A1 (en) | 2010-05-11 | 2011-11-23 | Ikerchem, S.L. | Polysubstituted benzofurans and medicinal applications thereof |
| JP5825608B2 (ja) * | 2010-08-06 | 2015-12-02 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
| US20210221784A1 (en) * | 2018-02-05 | 2021-07-22 | Université De Strasbourg | Compounds and compositions for the treatment of pain |
| WO2021023813A1 (en) * | 2019-08-06 | 2021-02-11 | Domain Therapeutics | 5-heteroaryl-pyridin-2-amine confounds as neuropeptide ff receptor antagonists |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU523040B2 (en) | 1978-05-15 | 1982-07-08 | Kanebo Limited | Calcium -antagonistic composition |
| GB8305245D0 (en) | 1983-02-25 | 1983-03-30 | Fujisawa Pharmaceutical Co | Imidazo-heterocyclic compounds |
| CA2034309C (en) | 1990-01-22 | 1997-04-01 | Takashi Iwaki | Mesomorphic compound, liquid crystal composition containing same, liquid crystal device using same and display apparatus |
| JPH09507071A (ja) * | 1993-12-21 | 1997-07-15 | イーライ・リリー・アンド・カンパニー | アミロイド原性ペプチドに関連した状態を治療又は予防する方法 |
| US5518713A (en) | 1995-02-13 | 1996-05-21 | 3V Inc. | Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them |
| JPH11116476A (ja) | 1997-10-16 | 1999-04-27 | Sankyo Co Ltd | 縮合複素環化合物 |
| EP2264018B1 (en) | 2000-08-24 | 2015-02-11 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thioflavin derivatives for use in the diagnosis of Alzheimer's disease |
| US7045539B2 (en) | 2000-12-22 | 2006-05-16 | Astrazeneca Ab | Therapeutic benzoxazole compounds |
| JP2004520347A (ja) * | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| JP4307001B2 (ja) * | 2001-03-14 | 2009-08-05 | キヤノン株式会社 | 金属配位化合物、電界発光素子及び表示装置 |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| EP1381604B1 (en) | 2001-04-23 | 2006-12-27 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| AU2002349477A1 (en) | 2001-11-26 | 2003-06-10 | Takeda Chemical Industries, Ltd. | Bicyclic derivative, process for producing the same, and use |
| GB0130305D0 (en) * | 2001-12-19 | 2002-02-06 | Amersham Plc | Compounds for imaging alzheimers disease |
| WO2003106439A1 (ja) | 2002-06-12 | 2003-12-24 | 株式会社ビーエフ研究所 | アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬 |
| TW200401194A (en) | 2002-07-11 | 2004-01-16 | Advanced Micro Devices Inc | Method and apparatus for determining a processor state without interrupting processor operation |
| CA2494139A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| EP1612204A4 (en) | 2003-03-31 | 2007-04-11 | Daiichi Seiyaku Co | HYDRAZONE DERIVATIVE |
| RU2340612C2 (ru) | 2003-05-13 | 2008-12-10 | Ф.Хоффманн-Ля Рош Аг | 2-имидазобензотиазолы как лиганды аденозинового рецептора |
| JP2007516196A (ja) * | 2003-07-02 | 2007-06-21 | ガラパゴス エヌブイ | Ｒｈｏキナーゼ阻害剤としてのピラジン及びピラリジン誘導体 |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| AU2006251832A1 (en) | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
| EP1902028A2 (en) * | 2005-07-04 | 2008-03-26 | Novo Nordisk A/S | Histamine h3 receptor antagonists |
| WO2007033080A2 (en) | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| JP2009508863A (ja) | 2005-09-16 | 2009-03-05 | ユニバーシティー オブ ピッツバーグ | 少なくとも１種のアミロイド形成タンパク質を含むアミロイド沈着物を検出するためのｉｎｖｉｖｏまたはｉｎｖｉｔｒｏ方法 |
| DK1945622T3 (da) | 2005-10-11 | 2012-04-02 | Univ Pittsburgh | Isotopisk-mærkede benzofuranforbindelser som billeddannelsesmidler til amyloidogene proteiner |
| US8022075B2 (en) | 2005-11-30 | 2011-09-20 | Fujifilm Ri Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
| TW200736252A (en) | 2006-01-27 | 2007-10-01 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
| WO2008118122A2 (en) | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| US20100092385A1 (en) | 2007-01-22 | 2010-04-15 | Astrazeneca Ab | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives |
| TW200901998A (en) * | 2007-03-06 | 2009-01-16 | Astrazeneca Ab | Novel 2-heteroaryl substituted benzothiophenes and benzofuranes |
-
2008
- 2008-03-03 TW TW097107378A patent/TW200901998A/zh unknown
- 2008-03-04 SA SA8290097A patent/SA08290097B1/ar unknown
- 2008-03-04 CL CL200800645A patent/CL2008000645A1/es unknown
- 2008-03-05 BR BRPI0808503A patent/BRPI0808503B8/pt active IP Right Grant
- 2008-03-05 UY UY30951A patent/UY30951A1/es not_active Application Discontinuation
- 2008-03-05 MX MX2009009469A patent/MX2009009469A/es active IP Right Grant
- 2008-03-05 MY MYPI20093695A patent/MY147347A/en unknown
- 2008-03-05 NZ NZ579157A patent/NZ579157A/en not_active IP Right Cessation
- 2008-03-05 CA CA2680157A patent/CA2680157C/en active Active
- 2008-03-05 US US12/042,795 patent/US7772256B2/en active Active
- 2008-03-05 CN CN2012100933476A patent/CN102617556A/zh active Pending
- 2008-03-05 PE PE2008000429A patent/PE20090164A1/es not_active Application Discontinuation
- 2008-03-05 EP EP08724190.7A patent/EP2132201B1/en active Active
- 2008-03-05 AU AU2008221668A patent/AU2008221668B2/en active Active
- 2008-03-05 ES ES08724190.7T patent/ES2615381T3/es active Active
- 2008-03-05 AR ARP080100905A patent/AR065599A1/es active IP Right Grant
- 2008-03-05 KR KR1020097018603A patent/KR101530392B1/ko active Active
- 2008-03-05 CN CN2008800149945A patent/CN101675042B/zh active Active
- 2008-03-05 JP JP2009552641A patent/JP5631009B2/ja active Active
- 2008-03-05 WO PCT/SE2008/050243 patent/WO2008108730A1/en not_active Ceased
- 2008-05-03 UA UAA200908596A patent/UA98481C2/ru unknown
-
2009
- 2009-08-20 IL IL200524A patent/IL200524A0/en unknown
- 2009-09-07 CO CO09095235A patent/CO6220965A2/es not_active Application Discontinuation
- 2009-09-21 EC EC2009009641A patent/ECSP099641A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/09/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/03/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |